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> Protein (NX_O76041)
Protein (NX_O76041)
Protein
Gene SymbolNEBL to neXtProt (NX_O76041)
DescriptionNebulette
Chromosome10
Location10p12.31 (21068902 ~ 21463116) to Ensembl
Sequene Features : Isoforms 2, Variants 229, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cardiac muscle thin filament assembly .actin filament binding
.filamin binding
.structural constituent of muscle
  + 2 more...
.extracellular exosome
.I band
.Z disc
.stress fiber
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 229 2
2014-09-19protein level
2 160 2
2014-05-27protein level
2 159 2
2014-02-25protein level
2 157 0
2013-12-09protein level
2 124 0
2013-11-01protein level
2 109 0
2013-09-12protein level
2 109 0
2013-08-17protein level
2 109 0
2013-07-15protein level
2 74 0
2013-06-11protein level
2 74 0
2013-02-12protein level
2 42 0
2012-12-20protein level
2 42 0
2012-10-30protein level
2 45 0
2012-10-07protein level
2 45 0
2012-08-24protein level
2 29 0
2012-07-28protein level
2 29 0
2012-06-08protein level
2 38 0
2012-05-07protein level
1 38 0
2012-04-10protein level
1 38 0
2012-01-13protein level
1 30 0
2011-12-20protein level
1 30 0
2011-11-11transcript level
1 30 0
2011-08-23transcript level
1 30 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O76041-1
46 7 0 116380.1664
NX_O76041-2
7 7 1 31176.0117
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2880203,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-2880203,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
3 EBI-2880203,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
4 EBI-2880203,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
5 EBI-2880203,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
6 EBI-2880203,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
7 EBI-2880203,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
8 EBI-2880203,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
9 EBI-2880203,EBI-742610 MAD1L1  
  .regulation of metaphase plate congression
.cell division
.small GTPase mediated signal transduction
  + 4 more...
.N/A .mitotic spindle
.actin cytoskeleton
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bone27
brain75
connective tissue46
embryonic tissue46
eye47
heart558
intestine34
kidney18
larynx127
liver34
lung89
mammary gland33
mouth60
muscle47
nerve128
ovary19
pancreas46
pharynx24
pituitary gland121
placenta60
prostate15
salivary gland49
skin4
testis20
thyroid150
trachea115
Health State
TissuesTPM*
normal66
breast (mammary gland) tumor42
chondrosarcoma72
colorectal tumor17
gastrointestinal tumor42
germ cell tumor22
glioma27
head and neck tumor97
liver tumor20
non-neoplasia103
pancreatic tumor57
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult50
embryoid body57
blastocyst81
fetus78
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.6
adrenal gland20.6
appendix2.2
cerebral cortex45.6
colon9.6
duodenum1.4
esophagus40.5
gallbladder4.6
heart muscle264.9
kidney30.6
liver2.4
lung46.2
lymph node1.3
ovary3
pancreas9.4
placenta17.8
prostate18
salivary gland51.3
skin47.4
small intestine1.9
stomach11.2
testis21.1
thyroid gland114.3
urinary bladder6.7
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bronchusLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderMedium
heart muscleHigh
kidneyLow
liverMedium
lungLow
lymph nodeLow
nasopharynxLow
pancreasMedium
parathyroid glandLow
rectumMedium
small intestineMedium
spleenLow
stomach 1Medium
stomach 2Medium
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605491, gene) Nebulette; NEBLOMIM


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