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> Protein (NX_O76064)
Protein (NX_O76064)
Protein
Gene SymbolRNF8 to neXtProt (NX_O76064)
DescriptionE3 ubiquitin-protein ligase RNF8
Chromosome6
Location6p21.2 (37321748 ~ 37362514) to Ensembl
Sequene Features : Isoforms 3, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked ubiquitination
.histone H2A K63-linked ubiquitination
.protein K63-linked ubiquitination
  + 16 more...
.protein homodimerization activity
.histone binding
.ubiquitin protein ligase binding
  + 4 more...
.site of double-strand break
.midbody
.nucleolus
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 56 1
2014-09-19protein level
3 43 1
2014-05-27protein level
3 43 1
2014-02-25protein level
2 35 1
2013-12-09protein level
2 32 1
2013-11-01protein level
2 32 1
2013-09-12protein level
2 32 1
2013-08-17protein level
2 32 1
2013-07-15protein level
2 15 1
2013-06-11protein level
2 15 1
2013-02-12protein level
2 4 1
2012-12-20protein level
2 4 1
2012-10-30protein level
2 3 1
2012-10-07protein level
2 3 1
2012-08-24protein level
2 3 1
2012-07-28protein level
2 3 1
2012-06-08protein level
2 7 1
2012-05-07protein level
2 7 1
2012-04-10protein level
2 7 1
2012-01-13protein level
2 10 1
2011-12-20protein level
2 10 1
2011-11-11protein level
2 10 1
2011-08-23protein level
2 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O76064-1
3 20 0 55481.8478
NX_O76064-2
1 5 0 10839.2575
NX_O76064-3
3 20 0 50796.3779
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373337,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
2 EBI-373337,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-373337,EBI-495644 MDC1  
  .cellular protein metabolic process
.post-translational protein modification
.intra-S DNA damage checkpoint
  + 4 more...
.FHA domain binding
.protein C-terminus binding
.focal adhesion
.chromosome
.nucleoplasm
.nucleus
4 EBI-373337,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
5 EBI-373337,EBI-8649725 TMEM79  
  .cornification
.establishment of skin barrier
.positive regulation of epidermis development
  + 4 more...
.N/A .trans-Golgi network membrane
.integral component of membrane
.lysosomal membrane
6 EBI-373337,EBI-727037 SEPT3  
  .cell division
.cell cycle
.GTP binding .synapse
.cell junction
.cytoskeleton
.cytoplasm
7 EBI-373337,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
8 EBI-373337,EBI-742610 MAD1L1  
  .regulation of metaphase plate congression
.cell division
.small GTPase mediated signal transduction
  + 4 more...
.N/A .mitotic spindle
.actin cytoskeleton
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder33
blood73
bone41
bone marrow20
brain55
cervix61
connective tissue13
embryonic tissue37
esophagus49
eye62
heart33
intestine43
kidney52
liver68
lung47
lymph22
lymph node22
mammary gland46
mouth30
muscle47
ovary78
pancreas60
pharynx24
placenta63
prostate15
skin28
stomach31
testis68
thymus25
tonsil58
uterus25
vascular19
Health State
TissuesTPM*
normal48
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma36
colorectal tumor62
esophageal tumor57
gastrointestinal tumor16
germ cell tumor41
glioma27
head and neck tumor22
kidney tumor58
leukemia42
liver tumor124
lung tumor38
lymphoma41
non-neoplasia10
ovarian tumor91
pancreatic tumor47
primitive neuroectodermal tumor of the CNS94
prostate cancer19
retinoblastoma129
skin tumor47
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult94
embryoid body14
blastocyst65
neonate32
fetus57
infant127
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.3
adrenal gland14.6
appendix8.7
bone marrow5.4
cerebral cortex13.6
colon9.4
duodenum8.7
esophagus15
gallbladder9.7
heart muscle14
kidney10.3
liver5.7
lung10.6
lymph node12.7
ovary13.1
pancreas4
placenta9.4
prostate10.3
salivary gland7.6
skin8.7
small intestine8
spleen8.8
stomach7.8
testis27.9
thyroid gland8
urinary bladder13.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611685, gene) Ring finger protein 8; RNF8OMIM


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