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> Protein (NX_O76071)
Protein (NX_O76071)
Protein
Gene SymbolCIAO1 to neXtProt (NX_O76071)
DescriptionProbable cytosolic iron-sulfur protein assembly protein CIAO1
Chromosome2
Location2q11.2 (96931870 ~ 96939087) to Ensembl
Sequene Features : Isoforms 1, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.iron-sulfur cluster assembly
.positive regulation of cell proliferation
  + 2 more...
.N/A .CIA complex
.MMXD complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 27 1
2014-09-19protein level
1 21 1
2014-05-27protein level
1 21 1
2014-02-25protein level
1 21 1
2013-12-09protein level
1 15 1
2013-11-01protein level
1 14 0
2013-09-12protein level
1 14 0
2013-08-17protein level
1 14 0
2013-07-15protein level
1 10 0
2013-06-11protein level
1 10 0
2013-02-12protein level
1 5 0
2012-12-20protein level
1 5 0
2012-10-30protein level
1 7 0
2012-10-07protein level
1 7 0
2012-08-24protein level
1 7 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 8 0
2012-05-07protein level
1 7 0
2012-04-10protein level
1 7 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O76071-1
17 0 0 37815.7144
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-725145,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
2 EBI-725145,EBI-744603 SF1  
  .negative regulation of nucleic acid-templated transcription
.regulation of steroid biosynthetic process
.negative regulation of smooth muscle cell proliferation
  + 7 more...
.poly(A) RNA binding
.zinc ion binding
.RNA binding
.transcription corepressor activity
.ribosome
.spliceosomal complex
.nucleoplasm
.nucleus
3 EBI-725145,EBI-10190644 MMS19  
  .positive regulation of transcription, DNA-templated
.small molecule metabolic process
.iron-sulfur cluster assembly
  + 8 more...
.protein binding, bridging
.estrogen receptor binding
.receptor signaling complex scaffold activity
.transcription coactivator activity
.CIA complex
.MMXD complex
.membrane
  + 5 more...
4 EBI-725145,EBI-752069 FAM96A  
  .iron-sulfur cluster assembly
.chromosome segregation
.metal ion binding .cytoplasm
.nucleoplasm
5 EBI-725145,EBI-744045 FAM96B  
  .small molecule metabolic process
.iron-sulfur cluster assembly
.chromosome segregation
.N/A .CIA complex
.MMXD complex
.spindle
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites150
bladder33
blood114
bone41
brain103
cervix123
connective tissue40
ear62
embryonic tissue122
esophagus49
eye81
heart55
intestine81
kidney61
larynx85
liver63
lung89
lymph112
lymph node33
mammary gland152
mouth90
muscle47
ovary147
pancreas4
parathyroid97
pituitary gland60
placenta67
prostate47
salivary gland49
skin166
spleen56
stomach52
testis78
thymus62
thyroid64
tonsil58
trachea77
uterus64
vascular19
Health State
TissuesTPM*
normal74
adrenal tumor79
breast (mammary gland) tumor182
cervical tumor173
chondrosarcoma48
colorectal tumor62
esophageal tumor57
gastrointestinal tumor84
germ cell tumor117
glioma55
head and neck tumor74
kidney tumor29
leukemia21
liver tumor83
lung tumor136
lymphoma110
non-neoplasia41
ovarian tumor144
pancreatic tumor9
primitive neuroectodermal tumor of the CNS86
prostate cancer67
retinoblastoma129
skin tumor191
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult82
embryoid body57
blastocyst179
fetus84
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.4
adrenal gland44.1
appendix34
bone marrow21.6
cerebral cortex37
colon32.1
duodenum34.4
esophagus27.5
gallbladder30.1
heart muscle36.9
kidney44.9
liver26.6
lung31.9
lymph node39.7
ovary34.6
pancreas14.9
placenta32.8
prostate27.5
salivary gland30.5
skin29.2
small intestine32.3
spleen38.4
stomach30.2
testis26.2
thyroid gland36.3
urinary bladder35.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604333, gene) Wd40 repeat-containing protein ciao1; CIAO1OMIM


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