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> Protein (NX_O76083)
Protein (NX_O76083)
Protein
Gene SymbolPDE9A to neXtProt (NX_O76083)
DescriptionHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Chromosome21
Location21q22.3 (44073746 ~ 44195619) to Ensembl
Sequene Features : Isoforms 16, Variants 101, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cGMP-mediated signaling
.metabolic process
.blood coagulation
.signal transduction
.3',5'-cyclic-GMP phosphodiesterase activity
.metal ion binding
.3',5'-cyclic-nucleotide phosphodiesterase activity
.perinuclear region of cytoplasm
.perikaryon
.ruffle membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
16 101 1
2014-09-19protein level
16 78 1
2014-05-27protein level
16 73 1
2014-02-25protein level
16 73 1
2013-12-09protein level
16 58 1
2013-11-01protein level
16 54 1
2013-09-12protein level
16 54 1
2013-08-17protein level
16 54 1
2013-07-15protein level
16 35 1
2013-06-11protein level
16 35 1
2013-02-12protein level
16 20 5
2012-12-20protein level
16 20 5
2012-10-30protein level
16 26 5
2012-10-07protein level
16 26 1
2012-08-24protein level
16 26 1
2012-07-28protein level
16 26 1
2012-06-08protein level
16 30 1
2012-05-07protein level
16 21 1
2012-04-10protein level
16 21 1
2012-01-13protein level
16 10 1
2011-12-20protein level
16 10 1
2011-11-11protein level
16 10 1
2011-08-23protein level
16 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O76083-1
0 29 0 68447.9681
NX_O76083-10
0 18 0 44104.3807
NX_O76083-11
0 20 0 53453.2743
NX_O76083-12
3 21 0 57312.269
NX_O76083-13
0 25 0 61183.3981
NX_O76083-14
0 26 0 64026.7694
NX_O76083-15
0 28 0 65673.6655
NX_O76083-16
2 20 0 56516.9687
NX_O76083-2
0 24 0 61668.546
NX_O76083-3
0 20 0 54403.976
NX_O76083-4
1 21 0 54060.6355
NX_O76083-5
3 23 0 62449.768
NX_O76083-6
0 21 0 57247.3473
NX_O76083-7
0 18 0 45259.9879
NX_O76083-8
0 23 0 58894.2434
NX_O76083-9
0 19 0 50678.9717
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742764,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
2 EBI-742764,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
3 EBI-742764,EBI-473775 CLK1  
  .protein autophosphorylation
.regulation of RNA splicing
.peptidyl-threonine phosphorylation
  + 2 more...
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.cytoplasm
.nucleus
4 EBI-742764,EBI-712512 SULT1E1  
  .sulfation
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.positive regulation of fat cell differentiation
  + 5 more...
.steroid sulfotransferase activity
.flavonol 3-sulfotransferase activity
.steroid binding
.estrone sulfotransferase activity
.cytosol
5 EBI-742764,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-742764,EBI-742790 TRIM32  
  .positive regulation of cell motility
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of viral release from host cell
  + 21 more...
.ubiquitin protein ligase activity
.protein self-association
.ubiquitin binding
  + 8 more...
.striated muscle myosin thick filament
.cytosol
.cytoplasm
.nucleus
7 EBI-742764,EBI-1052105 LAGE3  
  .tRNA processing .N/A .nucleus
8 EBI-742764,EBI-2212355 CRY2  
  .negative regulation of glucocorticoid secretion
.negative regulation of glucocorticoid receptor signaling pathway
.regulation of sodium-dependent phosphate transport
  + 16 more...
.FAD binding
.ubiquitin binding
.phosphatase binding
  + 7 more...
.mitochondrion
.cytoplasm
.nucleus
.extracellular region
9 EBI-742764,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
10 EBI-742764,EBI-10285660 PHYHIPL  
  .N/A .N/A .mitochondrion
.cytoplasm
11 EBI-742764,EBI-9106509 NAA38  
  .negative regulation of apoptotic process .N/A .NatC complex
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-742764,EBI-5457544 UTP23  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .small ribosomal subunit rRNA binding
.poly(A) RNA binding
.small-subunit processome
.nucleolus
13 EBI-742764,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
14 EBI-742764,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
15 EBI-742764,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
bone marrow20
brain16
connective tissue6
embryonic tissue28
eye33
intestine86
kidney18
liver4
lung2
lymph22
lymph node11
mammary gland6
mouth45
nerve64
ovary29
pancreas28
placenta21
prostate168
spleen37
testis11
thymus12
thyroid21
Health State
TissuesTPM*
normal22
chondrosarcoma12
colorectal tumor62
germ cell tumor18
glioma18
head and neck tumor29
kidney tumor43
leukemia10
lymphoma13
non-neoplasia10
ovarian tumor39
pancreatic tumor47
primitive neuroectodermal tumor of the CNS39
prostate cancer134
retinoblastoma107
Developmental Stage
TissuesTPM*
adult33
embryoid body14
blastocyst16
fetus30
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.2
adrenal gland7.5
appendix4.7
cerebral cortex9
colon44.7
duodenum3.9
esophagus4.8
gallbladder10
heart muscle3
kidney16
liver1.9
lung6.4
lymph node5.4
ovary2.3
pancreas2.5
placenta6.5
prostate43.7
salivary gland8.4
skin1.6
small intestine23.3
spleen20.1
stomach2.7
testis2.3
thyroid gland6.6
urinary bladder9.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
breastMedium
bronchusLow
cerebellumLow
cerebral cortexLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisHigh
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyLow
lateral ventricleMedium
lungMedium
pancreasLow
parathyroid glandMedium
prostateMedium
rectumLow
seminal vesicleMedium
soft tissue 1Low
stomach 2Medium
testisLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602973, gene) Phosphodiesterase 9a; PDE9AOMIM


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2014-2019 (C) Yonsei Proteome Research Center