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> Protein (NX_O94875)
Protein (NX_O94875)
Protein
Gene SymbolSORBS2 to neXtProt (NX_O94875)
DescriptionSorbin and SH3 domain-containing protein 2
Chromosome4
Location4q35.1 (186506598 ~ 186877806) to Ensembl
Sequene Features : Isoforms 12, Variants 167, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
12 167 19
2014-09-19protein level
12 128 19
2014-05-27protein level
12 128 20
2014-02-25protein level
12 128 20
2013-12-09protein level
12 104 20
2013-11-01protein level
12 104 20
2013-09-12protein level
12 104 25
2013-08-17protein level
12 104 26
2013-07-15protein level
10 67 23
2013-06-11protein level
10 67 23
2013-02-12protein level
7 36 92
2012-12-20protein level
7 35 92
2012-10-30protein level
7 41 92
2012-10-07protein level
7 41 19
2012-08-24protein level
7 30 19
2012-07-28protein level
7 30 19
2012-06-08protein level
7 1 19
2012-05-07protein level
7 1 19
2012-04-10protein level
6 1 19
2012-01-13protein level
6 1 19
2011-12-20protein level
6 1 19
2011-11-11protein level
6 1 16
2011-08-23protein level
6 1 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O94875-1
0 47 1 124029.7737
NX_O94875-10
9 30 1 91220.5265
NX_O94875-11
2 51 1 134509.8689
NX_O94875-12
0 36 1 80916.3455
NX_O94875-2
3 29 1 74731.9741
NX_O94875-3
0 31 1 71854.8968
NX_O94875-4
0 33 1 76665.238
NX_O94875-5
1 29 0 71126.6019
NX_O94875-6
1 7 0 17964.8866
NX_O94875-7
0 46 1 113483.8927
NX_O94875-8
1 30 1 73822.4764
NX_O94875-9
0 32 1 71641.7957
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-311323,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-311323,EBI-718488 EFS  
  .intracellular signal transduction
.cell adhesion
.protein domain specific binding .cytoplasm
3 EBI-311323,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
4 EBI-311323,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
5 EBI-311323,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
6 EBI-311323,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
7 EBI-311323,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
8 EBI-311323,EBI-2803991 PALLD  
  .cytoskeleton organization .muscle alpha-actinin binding .lamellipodium
.Z disc
.actin cytoskeleton
  + 7 more...
9 EBI-311323,EBI-10308083 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland333
bladder334
blood8
bone marrow20
brain141
cervix20
connective tissue100
ear62
embryonic tissue89
esophagus49
eye124
heart569
intestine64
kidney113
liver87
lung44
lymph158
mammary gland158
mouth136
muscle103
nerve128
ovary39
pancreas135
parathyroid97
pharynx122
placenta102
prostate163
skin14
spleen149
stomach20
testis52
thymus50
thyroid236
trachea231
uterus116
vascular174
Health State
TissuesTPM*
normal131
adrenal tumor79
breast (mammary gland) tumor182
cervical tumor28
chondrosarcoma72
colorectal tumor17
gastrointestinal tumor16
germ cell tumor182
glioma27
head and neck tumor74
kidney tumor43
liver tumor52
lung tumor29
lymphoma96
non-neoplasia103
ovarian tumor13
pancreatic tumor123
primitive neuroectodermal tumor of the CNS15
prostate cancer163
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult115
embryoid body85
blastocyst48
fetus177
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue64
adrenal gland271.4
appendix29
cerebral cortex35.3
colon74.6
duodenum17.9
esophagus166.9
gallbladder74.4
heart muscle765
kidney37
liver80.4
lung34
lymph node8
ovary34.6
pancreas79.8
placenta82.1
prostate142.4
salivary gland72.1
skin3.7
small intestine20.6
spleen50.1
stomach35.3
testis7.1
thyroid gland399.6
urinary bladder132.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastLow
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumLow
endometrium 1Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumLow
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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