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> Protein (NX_O94915)
Protein (NX_O94915)
Protein
Gene SymbolFRYL to neXtProt (NX_O94915)
DescriptionProtein furry homolog-like
Chromosome4
Location4p11 (48499378 ~ 48782339) to Ensembl
Sequene Features : Isoforms 2, Variants 300, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 300 13
2014-09-19protein level
2 225 13
2014-05-27protein level
2 225 14
2014-02-25protein level
2 223 14
2013-12-09protein level
2 166 14
2013-11-01protein level
2 158 11
2013-09-12protein level
2 158 11
2013-08-17protein level
2 158 11
2013-07-15protein level
2 90 11
2013-06-11protein level
2 90 11
2013-02-12protein level
2 33 9
2012-12-20protein level
2 25 9
2012-10-30protein level
2 50 9
2012-10-07protein level
2 50 9
2012-08-24protein level
2 36 9
2012-07-28protein level
2 36 9
2012-06-08protein level
2 36 9
2012-05-07protein level
2 36 9
2012-04-10protein level
2 36 9
2012-01-13protein level
2 14 9
2011-12-20protein level
2 14 9
2011-11-11protein level
2 14 9
2011-08-23protein level
2 14 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O94915-1
113 15 3 339382.0036
NX_O94915-2
2 15 0 45568.116
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1104821,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
2 EBI-1104821,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
3 EBI-1104821,EBI-519866 BAK1  
  .positive regulation of IRE1-mediated unfolded protein response
.apoptotic process involved in patterning of blood vessels
.positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 54 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
.identical protein binding
.pore complex
.integral component of mitochondrial outer membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites25
bladder66
blood32
bone41
bone marrow82
brain46
connective tissue20
ear496
embryonic tissue18
eye67
heart55
intestine107
kidney47
liver38
lung35
lymph22
lymph node111
mammary gland59
mouth60
muscle47
nerve128
ovary9
pancreas60
parathyroid242
pituitary gland60
placenta31
prostate36
skin42
stomach52
testis20
thymus125
thyroid107
tonsil58
trachea38
umbilical cord72
uterus34
Health State
TissuesTPM*
normal54
adrenal tumor158
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor124
gastrointestinal tumor59
germ cell tumor22
glioma18
head and neck tumor59
kidney tumor29
leukemia31
lung tumor9
lymphoma27
non-neoplasia51
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer48
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult53
embryoid body14
blastocyst16
neonate32
fetus52
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.5
adrenal gland9.1
appendix19.5
bone marrow24.5
cerebral cortex14.4
colon63
duodenum15.7
esophagus9.5
gallbladder14.1
heart muscle9.5
kidney10.7
liver5.4
lung14.9
lymph node19.5
ovary8.9
pancreas4.7
placenta10.9
prostate11.3
salivary gland10.9
skin18.1
small intestine20.7
spleen14.6
stomach16.3
testis9.6
thyroid gland14.1
urinary bladder14.7
Tissues
TissuesExpression level
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
pancreasMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineHigh
smooth muscleLow
soft tissue 2Low
spleenLow
stomach 1Low
stomach 2Low
testisMedium
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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