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> Protein (NX_O94921)
Protein (NX_O94921)
Protein
Gene SymbolCDK14 to neXtProt (NX_O94921)
DescriptionCyclin-dependent kinase 14
Chromosome7
Location7q21.13 (90095738 ~ 90839905) to Ensembl
Sequene Features : Isoforms 3, Variants 86, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 86 4
2014-09-19protein level
3 70 4
2014-05-27protein level
3 70 4
2014-02-25protein level
3 69 4
2013-12-09protein level
3 62 4
2013-11-01protein level
3 61 4
2013-09-12protein level
3 61 4
2013-08-17protein level
3 61 4
2013-07-15protein level
3 36 4
2013-06-11protein level
3 36 4
2013-02-12protein level
3 18 23
2012-12-20protein level
3 19 23
2012-10-30protein level
3 21 23
2012-10-07protein level
3 21 9
2012-08-24protein level
3 20 9
2012-07-28protein level
3 20 9
2012-06-08protein level
3 24 9
2012-05-07protein level
3 15 9
2012-04-10protein level
3 15 9
2012-01-13protein level
3 10 9
2011-12-20protein level
3 10 9
2011-11-11protein level
3 10 9
2011-08-23protein level
3 10 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O94921-1
3 16 4 53023.1698
NX_O94921-2
1 16 4 50629.716
NX_O94921-3
0 16 4 47729.4152
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1043945,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
2 EBI-1043945,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
3 EBI-1043945,EBI-375013 CCND3  
  .cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
.T cell proliferation
  + 3 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase activity
.membrane
.cytoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
4 EBI-1043945,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
5 EBI-1043945,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
6 EBI-1043945,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
7 EBI-1043945,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
8 EBI-1043945,EBI-1049189 CCNY  
  .regulation of canonical Wnt signaling pathway
.cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .extracellular exosome
.plasma membrane
.nucleus
.cytoplasmic cyclin-dependent protein kinase holoenzyme complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood16
bone27
brain117
cervix20
kidney4
liver4
lymph node33
prostate5
spleen18
stomach31
Health State
TissuesTPM*
normal6
breast (mammary gland) tumor21
cervical tumor28
gastrointestinal tumor25
leukemia10
liver tumor10
Developmental Stage
TissuesTPM*
adult14
embryoid body28
blastocyst16
fetus52
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.7
adrenal gland6.5
appendix12.4
bone marrow13.8
cerebral cortex44.3
colon5.4
duodenum4.4
esophagus8.1
gallbladder31.8
heart muscle19.5
kidney23.8
liver11.3
lung12
lymph node23.4
ovary26.8
pancreas13.6
placenta9.4
prostate13.1
salivary gland9.1
skin2.7
small intestine3.3
spleen11.6
stomach10.8
testis15.2
thyroid gland31.3
urinary bladder16.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610679, gene) Pftaire protein kinase 1; PFTK1OMIM


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