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> Protein (NX_O94955)
Protein (NX_O94955)
Protein
Gene SymbolRHOBTB3 to neXtProt (NX_O94955)
DescriptionRho-related BTB domain-containing protein 3
Chromosome5
Location5q15 (95049226 ~ 95160087) to Ensembl
Sequene Features : Isoforms 1, Variants 61, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.retrograde transport, endosome to Golgi
.metabolic process
.small GTPase mediated signal transduction
.Rab GTPase binding
.ATPase activity
.GTP binding
.ATP binding
.extracellular exosome
.Golgi apparatus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 61 2
2014-09-19protein level
1 49 2
2014-05-27protein level
1 49 2
2014-02-25protein level
1 49 2
2013-12-09protein level
1 37 2
2013-11-01protein level
1 35 0
2013-09-12protein level
1 35 0
2013-08-17protein level
1 35 0
2013-07-15protein level
1 22 0
2013-06-11protein level
1 22 0
2013-02-12protein level
1 15 0
2012-12-20protein level
1 15 0
2012-10-30protein level
1 19 0
2012-10-07protein level
1 19 0
2012-08-24protein level
1 19 0
2012-07-28protein level
1 19 0
2012-06-08protein level
1 24 0
2012-05-07protein level
1 19 0
2012-04-10protein level
1 19 0
2012-01-13protein level
1 13 0
2011-12-20protein level
1 13 0
2011-11-11protein level
1 13 0
2011-08-23protein level
1 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O94955-1
28 0 0 69367.9545
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2367123,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-2367123,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
3 EBI-2367123,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites50
blood24
bone139
bone marrow82
brain53
cervix164
connective tissue80
ear310
embryonic tissue263
eye86
heart100
intestine81
kidney42
liver136
lung89
mammary gland66
mouth60
muscle103
nerve128
ovary29
pancreas145
parathyroid145
placenta674
prostate26
salivary gland197
skin317
spleen37
stomach10
testis50
thymus50
thyroid214
trachea19
umbilical cord217
uterus38
vascular290
Health State
TissuesTPM*
normal156
adrenal tumor79
breast (mammary gland) tumor64
cervical tumor231
chondrosarcoma169
colorectal tumor62
gastrointestinal tumor42
germ cell tumor83
glioma18
head and neck tumor74
kidney tumor43
leukemia52
liver tumor114
lung tumor116
non-neoplasia124
ovarian tumor39
pancreatic tumor133
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma64
skin tumor127
soft tissue/muscle tissue tumor47
uterine tumor11
Developmental Stage
TissuesTPM*
adult147
embryoid body414
blastocyst32
neonate193
fetus120
infant170
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue59.9
adrenal gland38.3
appendix13.2
bone marrow6.4
cerebral cortex38
colon20.3
duodenum13.2
esophagus15
gallbladder20.6
heart muscle25.5
kidney23.8
liver9.6
lung16.2
lymph node6.4
ovary73.7
pancreas51.5
placenta92.5
prostate25.8
salivary gland29.8
skin10.5
small intestine14.6
spleen10.6
stomach8.7
testis24.8
thyroid gland22.2
urinary bladder22.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607353, gene) Rho-related btb domain-containing protein 3; RHOBTB3OMIM


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