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> Protein (NX_O94979)
Protein (NX_O94979)
Protein
Gene SymbolSEC31A to neXtProt (NX_O94979)
DescriptionProtein transport protein Sec31A
Chromosome4
Location4q21.22 (83739814 ~ 83822319) to Ensembl
Sequene Features : Isoforms 10, Variants 126, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.response to calcium ion
.COPII vesicle coating
  + 9 more...
.calcium-dependent protein binding .endoplasmic reticulum exit site
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 126 12
2014-09-19protein level
10 102 12
2014-05-27protein level
10 101 12
2014-02-25protein level
9 100 12
2013-12-09protein level
9 77 12
2013-11-01protein level
9 72 10
2013-09-12protein level
9 72 10
2013-08-17protein level
9 72 10
2013-07-15protein level
9 49 9
2013-06-11protein level
9 49 9
2013-02-12protein level
9 22 58
2012-12-20protein level
9 22 58
2012-10-30protein level
8 29 50
2012-10-07protein level
8 29 8
2012-08-24protein level
8 27 8
2012-07-28protein level
8 27 8
2012-06-08protein level
8 9 8
2012-05-07protein level
8 9 8
2012-04-10protein level
8 9 8
2012-01-13protein level
8 7 6
2011-12-20protein level
8 7 6
2011-11-11protein level
8 7 5
2011-08-23protein level
8 7 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O94979-1
0 43 0 132930.6312
NX_O94979-10
0 40 0 127474.9237
NX_O94979-2
0 42 0 131450.8674
NX_O94979-3
0 42 0 121574.3269
NX_O94979-4
0 41 0 128954.6875
NX_O94979-5
0 21 0 56695.3041
NX_O94979-6
0 40 0 117598.3832
NX_O94979-7
5 30 0 105685.5365
NX_O94979-8
1 42 0 134414.2885
NX_O94979-9
3 41 0 130664.2959
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1767898,EBI-352915 PDCD6  
  .apoptotic signaling pathway
.negative regulation of protein kinase B signaling
.response to calcium ion
  + 12 more...
.binding, bridging
.calcium-dependent protein binding
.protein dimerization activity
  + 4 more...
.endoplasmic reticulum exit site
.extracellular exosome
.nuclear membrane
  + 6 more...
2 EBI-1767898,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
ascites175
bladder66
blood171
bone265
bone marrow184
brain136
cervix103
connective tissue268
ear434
embryonic tissue258
esophagus49
eye167
heart22
intestine81
kidney156
larynx85
liver58
lung95
lymph45
lymph node222
mammary gland165
mouth362
muscle141
nerve321
ovary88
pancreas93
parathyroid48
pharynx73
pituitary gland121
placenta201
prostate168
salivary gland49
skin194
spleen74
stomach125
testis183
thymus125
thyroid257
tonsil117
trachea1081
umbilical cord72
uterus206
vascular232
Health State
TissuesTPM*
normal154
bladder carcinoma56
breast (mammary gland) tumor107
cervical tumor144
chondrosarcoma132
colorectal tumor88
esophageal tumor57
gastrointestinal tumor135
germ cell tumor265
glioma74
head and neck tumor276
kidney tumor145
leukemia211
liver tumor62
lung tumor165
lymphoma41
non-neoplasia124
ovarian tumor78
pancreatic tumor123
primitive neuroectodermal tumor of the CNS31
prostate cancer298
retinoblastoma215
skin tumor127
soft tissue/muscle tissue tumor191
uterine tumor99
Developmental Stage
TissuesTPM*
adult182
embryoid body371
blastocyst227
neonate225
fetus163
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue66.4
adrenal gland78.5
appendix61.1
bone marrow48.6
cerebral cortex36.7
colon74.5
duodenum90.8
esophagus68.7
gallbladder98.4
heart muscle71.9
kidney75.8
liver76.7
lung66.5
lymph node53.1
ovary123.1
pancreas76.8
placenta106.3
prostate83.3
salivary gland83.2
skin67.5
small intestine83
spleen54.2
stomach81.6
testis58.2
thyroid gland106.5
urinary bladder91.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610257, gene) Sec31, yeast, homolog of, a; SEC31AOMIM


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