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> Protein (NX_O95163)
Protein (NX_O95163)
Protein
Gene SymbolIKBKAP to neXtProt (NX_O95163)
DescriptionElongator complex protein 1
Chromosome9
Location9q31.3 (111629797 ~ 111696396) to Ensembl
Sequene Features : Isoforms 1, Variants 183, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of protein kinase activity
.positive regulation of cell migration
.signal transduction
  + 6 more...
.phosphorylase kinase regulator activity
.signal transducer activity
.Elongator holoenzyme complex
.transcription elongation factor complex
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 183 6
2014-09-19protein level
1 154 6
2014-05-27protein level
1 154 6
2014-02-25protein level
1 152 6
2013-12-09protein level
1 116 6
2013-11-01protein level
1 110 6
2013-09-12protein level
1 110 6
2013-08-17protein level
1 110 6
2013-07-15protein level
1 77 3
2013-06-11protein level
1 77 3
2013-02-12protein level
1 52 4
2012-12-20protein level
1 50 4
2012-10-30protein level
1 62 4
2012-10-07protein level
1 62 4
2012-08-24protein level
1 50 4
2012-07-28protein level
1 50 4
2012-06-08protein level
1 54 4
2012-05-07protein level
1 54 4
2012-04-10protein level
1 54 4
2012-01-13protein level
1 33 4
2011-12-20protein level
1 33 4
2011-11-11protein level
1 33 4
2011-08-23protein level
1 33 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95163-1
60 0 0 150158.5364
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347559,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
2 EBI-347559,EBI-751345 IRF4  
  .T-helper 17 cell lineage commitment
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 15 more...
.sequence-specific DNA binding
.protein-lysine N-methyltransferase activity
.transcription factor binding
  + 3 more...
.membrane
.cytosol
.cytoplasm
  + 3 more...
3 EBI-347559,EBI-355217 ELP3  
  .regulation of protein kinase activity
.histone H4 acetylation
.histone H3 acetylation
  + 7 more...
.iron-sulfur cluster binding
.metal ion binding
.H4 histone acetyltransferase activity
  + 2 more...
.Elongator holoenzyme complex
.transcription elongation factor complex
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland425
ascites50
bladder100
blood8
bone55
brain88
connective tissue33
ear62
embryonic tissue75
eye71
heart55
intestine12
kidney23
larynx42
liver48
lung80
lymph node22
mammary gland85
mouth60
muscle103
ovary137
pancreas42
parathyroid145
pharynx122
pituitary gland60
placenta17
prostate52
skin37
stomach41
testis64
thymus12
thyroid64
trachea154
uterus90
Health State
TissuesTPM*
normal63
adrenal tumor553
breast (mammary gland) tumor96
chondrosarcoma48
colorectal tumor8
gastrointestinal tumor42
germ cell tumor110
glioma9
head and neck tumor89
kidney tumor29
leukemia31
liver tumor83
lung tumor58
lymphoma41
non-neoplasia20
ovarian tumor65
pancreatic tumor19
primitive neuroectodermal tumor of the CNS70
prostate cancer67
retinoblastoma86
skin tumor23
soft tissue/muscle tissue tumor39
uterine tumor77
Developmental Stage
TissuesTPM*
adult64
embryoid body100
blastocyst81
fetus96
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.9
adrenal gland54.6
appendix13.9
bone marrow8.9
cerebral cortex18.9
colon12.1
duodenum8.7
esophagus11.3
gallbladder13.2
heart muscle14.6
kidney13.9
liver10.2
lung13.7
lymph node16.6
ovary34.1
pancreas6.5
placenta10.9
prostate15.2
salivary gland11
skin16.5
small intestine11
spleen16.5
stomach12.3
testis16
thyroid gland18.6
urinary bladder12.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#223900, phenotype) Neuropathy, hereditary sensory and autonomic, type iii; HSAN3OMIM
2(*603722, gene) Inhibitor of kappa light polypeptide gene enhancer in b cells, kinaseOMIM


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