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> Protein (NX_O95197)
Protein (NX_O95197)
Protein
Gene SymbolRTN3 to neXtProt (NX_O95197)
DescriptionReticulon-3
Chromosome11
Location11q13.1 (63448918 ~ 63527363) to Ensembl
Sequene Features : Isoforms 7, Variants 124, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.endoplasmic reticulum tubular network organization
.vesicle-mediated transport
.viral process
.apoptotic process
.N/A .extracellular exosome
.integral component of membrane
.endoplasmic reticulum membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 124 11
2014-09-19protein level
7 86 11
2014-05-27protein level
7 85 12
2014-02-25protein level
7 85 12
2013-12-09protein level
7 61 12
2013-11-01protein level
7 59 12
2013-09-12protein level
7 59 13
2013-08-17protein level
7 59 13
2013-07-15protein level
6 40 11
2013-06-11protein level
6 40 11
2013-02-12protein level
6 24 25
2012-12-20protein level
5 22 24
2012-10-30protein level
5 29 24
2012-10-07protein level
5 29 9
2012-08-24protein level
5 29 9
2012-07-28protein level
5 29 9
2012-06-08protein level
5 30 9
2012-05-07protein level
5 27 9
2012-04-10protein level
5 27 9
2012-01-13protein level
5 13 9
2011-12-20protein level
5 13 9
2011-11-11protein level
5 13 8
2011-08-23protein level
5 13 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95197-1
1 44 0 112541.1096
NX_O95197-2
1 44 0 110583.2243
NX_O95197-3
0 9 0 25592.5273
NX_O95197-4
1 8 0 27550.4126
NX_O95197-5
2 8 0 26434.9986
NX_O95197-6
5 4 0 23473.9013
NX_O95197-7
1 41 0 100761.4612
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740467,EBI-358858 CDIPT  
  .glycerophospholipid biosynthetic process
.CDP-diacylglycerol metabolic process
.small molecule metabolic process
  + 2 more...
.alcohol binding
.carbohydrate binding
.manganese ion binding
  + 2 more...
.integral component of membrane
.membrane
.plasma membrane
  + 3 more...
2 EBI-740467,EBI-742898 PTPN9  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
3 EBI-740467,EBI-2822329 SNX1  
  .lamellipodium morphogenesis
.positive regulation of protein catabolic process
.retrograde transport, endosome to Golgi
  + 4 more...
.leptin receptor binding
.transferrin receptor binding
.identical protein binding
  + 3 more...
.protein complex
.intracellular membrane-bounded organelle
.early endosome membrane
  + 8 more...
4 EBI-740467,EBI-2561661 PPP2R3C  
  .regulation of mitochondrial depolarization
.spleen development
.positive regulation of B cell differentiation
  + 6 more...
.metal ion binding .spindle
.centrosome
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland242
ascites326
bladder234
blood384
bone83
bone marrow205
brain1434
cervix268
connective tissue134
embryonic tissue263
esophagus496
eye292
heart256
intestine219
kidney393
liver77
lung170
lymph225
lymph node100
mammary gland171
mouth287
muscle28
nerve321
ovary147
pancreas182
parathyroid291
pharynx98
pituitary gland181
placenta180
prostate195
skin199
spleen149
stomach156
testis395
thymus138
thyroid236
trachea270
umbilical cord217
uterus129
vascular271
Health State
TissuesTPM*
normal487
adrenal tumor395
bladder carcinoma113
breast (mammary gland) tumor150
cervical tumor376
chondrosarcoma132
colorectal tumor239
esophageal tumor463
gastrointestinal tumor244
germ cell tumor558
glioma279
head and neck tumor171
kidney tumor885
leukemia338
liver tumor124
lung tumor126
lymphoma180
non-neoplasia310
ovarian tumor183
pancreatic tumor247
primitive neuroectodermal tumor of the CNS291
prostate cancer173
retinoblastoma538
skin tumor39
soft tissue/muscle tissue tumor71
uterine tumor133
Developmental Stage
TissuesTPM*
adult216
embryoid body228
blastocyst260
neonate611
fetus883
infant212
juvenile485
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue138.6
adrenal gland66.9
appendix47.6
bone marrow57.4
cerebral cortex389.8
colon71.9
duodenum40.8
esophagus43.9
gallbladder49.7
heart muscle36.1
kidney62.3
liver38.7
lung58.6
lymph node28.7
ovary36.6
pancreas35.8
placenta46.1
prostate42.8
salivary gland82.9
skin68.3
small intestine48.9
spleen30.7
stomach44.1
testis40.4
thyroid gland130.4
urinary bladder52.2
Tissues
TissuesExpression level
cerebellumHigh
cerebral cortexHigh
colonHigh
heart muscleLow
hippocampusHigh
lateral ventricleMedium
skeletal muscleMedium
soft tissue 1Medium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604249, gene) Reticulon 3; RTN3OMIM


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