Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O95198)
Protein (NX_O95198)
Protein
Gene SymbolKLHL2 to neXtProt (NX_O95198)
DescriptionKelch-like protein 2
Chromosome4
Location4q32.3 (166128770 ~ 166244308) to Ensembl
Sequene Features : Isoforms 3, Variants 55, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination .actin binding .Cul3-RING ubiquitin ligase complex
.lamellipodium
.actin cytoskeleton
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 55 0
2014-09-19protein level
3 44 0
2014-05-27protein level
3 44 0
2014-02-25protein level
3 42 0
2013-12-09protein level
3 36 0
2013-11-01protein level
3 34 0
2013-09-12protein level
3 34 0
2013-08-17protein level
3 34 0
2013-07-15protein level
2 21 0
2013-06-11protein level
2 21 0
2013-02-12protein level
2 8 0
2012-12-20protein level
2 8 0
2012-10-30protein level
2 10 0
2012-10-07protein level
2 10 0
2012-08-24protein level
2 10 0
2012-07-28protein level
2 10 0
2012-06-08protein level
2 15 0
2012-05-07protein level
2 14 0
2012-04-10protein level
2 14 0
2012-01-13protein level
1 12 0
2011-12-20protein level
1 12 0
2011-11-11protein level
1 12 0
2011-08-23protein level
1 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95198-1
1 29 1 65931.7054
NX_O95198-2
1 29 1 66581.1098
NX_O95198-3
0 25 1 56049.9561
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746999,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-746999,EBI-431907 TNPO2  
  .intracellular protein transport .nuclear localization sequence binding .cytoplasm
.nucleus
3 EBI-746999,EBI-2564581 TXNDC12  
  .cell redox homeostasis .protein-disulfide reductase (glutathione) activity .endoplasmic reticulum lumen
4 EBI-746999,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
5 EBI-746999,EBI-10212133 BCAM  
  .signal transduction
.cell-matrix adhesion
.cell adhesion
.laminin binding
.protein C-terminus binding
.laminin receptor activity
.transmembrane signaling receptor activity
.extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
6 EBI-746999,EBI-456129 CUL3  
  .intrinsic apoptotic signaling pathway
.negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
  + 22 more...
.POZ domain binding .extracellular exosome
.Cul3-RING ubiquitin ligase complex
.membrane
  + 4 more...
7 EBI-746999,EBI-10265237 ZNF114  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.extracellular exosome
.nucleus
8 EBI-746999,EBI-1045338 TMA16  
  .N/A .N/A .nucleolus
.nucleus
9 EBI-746999,EBI-9247198 CCDC43  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood24
brain43
connective tissue26
embryonic tissue18
eye28
heart11
intestine4
kidney4
liver29
lung17
lymph node11
mammary gland13
ovary19
pancreas18
placenta10
prostate5
skin4
stomach52
testis6
thymus12
thyroid107
vascular38
Health State
TissuesTPM*
normal22
chondrosarcoma36
gastrointestinal tumor42
germ cell tumor7
glioma9
head and neck tumor37
leukemia21
liver tumor31
non-neoplasia31
ovarian tumor26
pancreatic tumor19
prostate cancer9
skin tumor7
Developmental Stage
TissuesTPM*
adult19
embryoid body28
blastocyst16
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.9
adrenal gland16.6
appendix16.9
bone marrow13
cerebral cortex50.2
colon8.9
duodenum6.6
esophagus21.6
gallbladder14
heart muscle6.1
kidney15.1
liver17.6
lung15.1
lymph node13.2
ovary4.2
pancreas4.5
placenta8.1
prostate8.9
salivary gland16.2
skin5.7
small intestine7.2
spleen13.9
stomach9.3
testis8.7
thyroid gland16.9
urinary bladder15.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605774, gene) Kelch-like 2; KLHL2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center