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> Protein (NX_O95218)
Protein (NX_O95218)
Protein
Gene SymbolZRANB2 to neXtProt (NX_O95218)
DescriptionZinc finger Ran-binding domain-containing protein 2
Chromosome1
Location1p31.1 (71528974 ~ 71546980) to Ensembl
Sequene Features : Isoforms 2, Variants 40, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.regulation of transcription, DNA-templated
.poly(A) RNA binding
.zinc ion binding
.RNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 40 16
2014-09-19protein level
2 34 16
2014-05-27protein level
2 34 16
2014-02-25protein level
2 34 15
2013-12-09protein level
2 29 15
2013-11-01protein level
2 28 14
2013-09-12protein level
2 28 17
2013-08-17protein level
2 28 17
2013-07-15protein level
2 17 16
2013-06-11protein level
2 17 16
2013-02-12protein level
2 7 27
2012-12-20protein level
2 7 27
2012-10-30protein level
2 8 27
2012-10-07protein level
2 8 14
2012-08-24protein level
2 3 14
2012-07-28protein level
2 3 14
2012-06-08protein level
2 4 14
2012-05-07protein level
2 4 14
2012-04-10protein level
2 4 14
2012-01-13protein level
2 6 14
2011-12-20protein level
2 6 14
2011-11-11protein level
2 6 15
2011-08-23protein level
2 6 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95218-1
1 16 0 37381.9118
NX_O95218-2
1 16 0 36296.3493
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1051583,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
2 EBI-1051583,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
3 EBI-1051583,EBI-1042725 AKAP17A  
  .regulation of RNA splicing
.B cell activation
.RNA splicing
  + 3 more...
.protein kinase A binding
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.cytoplasm
.spliceosomal complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland273
ascites150
bladder133
blood98
bone83
bone marrow164
brain156
cervix41
connective tissue67
ear248
embryonic tissue145
esophagus49
eye100
heart111
intestine56
kidney85
larynx127
liver852
lung59
lymph22
lymph node200
mammary gland33
mouth120
muscle291
nerve193
ovary59
pancreas79
parathyroid97
pharynx73
pituitary gland242
placenta113
prostate116
salivary gland49
skin52
spleen131
stomach104
testis121
thymus238
thyroid193
trachea154
uterus180
vascular309
Health State
TissuesTPM*
normal178
adrenal tumor158
bladder carcinoma227
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma96
colorectal tumor53
esophageal tumor57
gastrointestinal tumor143
germ cell tumor174
glioma27
head and neck tumor134
kidney tumor159
leukemia95
liver tumor135
lymphoma41
non-neoplasia62
ovarian tumor52
pancreatic tumor95
primitive neuroectodermal tumor of the CNS86
prostate cancer48
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor71
uterine tumor155
Developmental Stage
TissuesTPM*
adult118
embryoid body57
blastocyst195
neonate32
fetus136
infant127
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue41.1
adrenal gland56.2
appendix64.1
bone marrow57.4
cerebral cortex47.5
colon46.1
duodenum48.6
esophagus36.9
gallbladder48.9
heart muscle40.5
kidney33.2
liver18.5
lung64.3
lymph node84.1
ovary76.6
pancreas15.3
placenta41.1
prostate67.2
salivary gland45.3
skin61.6
small intestine53.4
spleen60.6
stomach43.9
testis62
thyroid gland70.3
urinary bladder45.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604347, gene) Zinc finger protein 265; ZNF265OMIM


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