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	> Protein (NX_O95218) Protein (NX_O95218) Protein Gene Symbol ZRANB2 to neXtProt (NX_O95218) Description Zinc finger Ran-binding domain-containing protein 2 Chromosome 1 Location 1p31.1 (71528974 ~ 71546980) to Ensembl Sequene Features : Isoforms 2, Variants 40, PTMs 16 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .RNA splicing .mRNA processing .regulation of transcription, DNA-templated .poly(A) RNA binding .zinc ion binding .RNA binding .sequence-specific DNA binding transcription factor activity .nucleoplasm .nucleus Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 40 16 2014-09-19 protein level 2 34 16 2014-05-27 protein level 2 34 16 2014-02-25 protein level 2 34 15 2013-12-09 protein level 2 29 15 2013-11-01 protein level 2 28 14 2013-09-12 protein level 2 28 17 2013-08-17 protein level 2 28 17 2013-07-15 protein level 2 17 16 2013-06-11 protein level 2 17 16 2013-02-12 protein level 2 7 27 2012-12-20 protein level 2 7 27 2012-10-30 protein level 2 8 27 2012-10-07 protein level 2 8 14 2012-08-24 protein level 2 3 14 2012-07-28 protein level 2 3 14 2012-06-08 protein level 2 4 14 2012-05-07 protein level 2 4 14 2012-04-10 protein level 2 4 14 2012-01-13 protein level 2 6 14 2011-12-20 protein level 2 6 14 2011-11-11 protein level 2 6 15 2011-08-23 protein level 2 6 15 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_O95218-1 1 16 0 37381.9118 NX_O95218-2 1 16 0 36296.3493 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-1051583,EBI-714559 ARRB2     .positive regulation of DNA biosynthetic process .negative regulation of release of cytochrome c from mitochondria .positive regulation of ERK1 and ERK2 cascade   + 35 more... .protein complex scaffold .angiotensin receptor binding .ubiquitin protein ligase binding   + 3 more... .postsynaptic membrane .dendritic spine .cytoplasmic vesicle   + 8 more... 2 EBI-1051583,EBI-743313 ARRB1     .positive regulation of histone H4 acetylation .positive regulation of ERK1 and ERK2 cascade .membrane organization   + 24 more... .transcription regulatory region DNA binding .cysteine-type endopeptidase inhibitor activity involved in apoptotic process .angiotensin receptor binding   + 5 more... .cytoplasmic vesicle .pseudopodium .cytoplasmic vesicle membrane   + 9 more... 3 EBI-1051583,EBI-1042725 AKAP17A     .regulation of RNA splicing .B cell activation .RNA splicing   + 3 more... .protein kinase A binding .poly(A) RNA binding .nucleotide binding .nuclear speck .cytoplasm .spliceosomal complex   + 2 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adipose tissue 233 adrenal gland 273 ascites 150 bladder 133 blood 98 bone 83 bone marrow 164 brain 156 cervix 41 connective tissue 67 ear 248 embryonic tissue 145 esophagus 49 eye 100 heart 111 intestine 56 kidney 85 larynx 127 liver 852 lung 59 lymph 22 lymph node 200 mammary gland 33 mouth 120 muscle 291 nerve 193 ovary 59 pancreas 79 parathyroid 97 pharynx 73 pituitary gland 242 placenta 113 prostate 116 salivary gland 49 skin 52 spleen 131 stomach 104 testis 121 thymus 238 thyroid 193 trachea 154 uterus 180 vascular 309 Health State Tissues TPM* normal 178 adrenal tumor 158 bladder carcinoma 227 breast (mammary gland) tumor 32 cervical tumor 57 chondrosarcoma 96 colorectal tumor 53 esophageal tumor 57 gastrointestinal tumor 143 germ cell tumor 174 glioma 27 head and neck tumor 134 kidney tumor 159 leukemia 95 liver tumor 135 lymphoma 41 non-neoplasia 62 ovarian tumor 52 pancreatic tumor 95 primitive neuroectodermal tumor of the CNS 86 prostate cancer 48 retinoblastoma 64 skin tumor 55 soft tissue/muscle tissue tumor 71 uterine tumor 155 Developmental Stage Tissues TPM* adult 118 embryoid body 57 blastocyst 195 neonate 32 fetus 136 infant 127 juvenile 143 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 41.1 adrenal gland 56.2 appendix 64.1 bone marrow 57.4 cerebral cortex 47.5 colon 46.1 duodenum 48.6 esophagus 36.9 gallbladder 48.9 heart muscle 40.5 kidney 33.2 liver 18.5 lung 64.3 lymph node 84.1 ovary 76.6 pancreas 15.3 placenta 41.1 prostate 67.2 salivary gland 45.3 skin 61.6 small intestine 53.4 spleen 60.6 stomach 43.9 testis 62 thyroid gland 70.3 urinary bladder 45.3 Tissues Tissues Expression level adrenal gland Medium appendix Medium bone marrow Low breast Medium bronchus High cerebellum High cerebral cortex Medium cervix, uterine High colon Medium duodenum Medium endometrium 1 Medium endometrium 2 Medium epididymis High esophagus High fallopian tube High gallbladder High heart muscle High hippocampus Low kidney High lateral ventricle Low liver Medium lung Medium lymph node Medium ovary Medium pancreas High parathyroid gland Medium placenta High prostate Medium rectum High salivary gland High seminal vesicle Medium skeletal muscle Medium skin 1 High skin 2 High small intestine High smooth muscle Medium soft tissue 1 Medium soft tissue 2 Medium spleen Low stomach 1 High stomach 2 High testis High thyroid gland Medium tonsil Medium urinary bladder High vagina High Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*604347, gene) Zinc finger protein 265; ZNF265 OMIM

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