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Protein |
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Gene Symbol | ZRANB2 to neXtProt (NX_O95218) |
Description | Zinc finger Ran-binding domain-containing protein 2 |
Chromosome | 1 |
Location | 1p31.1 (71528974 ~ 71546980) to Ensembl |
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Sequene Features : Isoforms 2, Variants 40, PTMs 16 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.RNA splicing .mRNA processing .regulation of transcription, DNA-templated |
.poly(A) RNA binding .zinc ion binding .RNA binding .sequence-specific DNA binding transcription factor activity |
.nucleoplasm .nucleus |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 40 |
| 16 |
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2014-09-19 | | protein level | | | | | | | 2 |
| 34 |
| 16 |
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2014-05-27 | | protein level | | | | | | | 2 |
| 34 |
| 16 |
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2014-02-25 | | protein level | | | | | | | 2 |
| 34 |
| 15 |
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2013-12-09 | | protein level | | | | | | | 2 |
| 29 |
| 15 |
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2013-11-01 | | protein level | | | | | | | 2 |
| 28 |
| 14 |
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2013-09-12 | | protein level | | | | | | | 2 |
| 28 |
| 17 |
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2013-08-17 | | protein level | | | | | | | 2 |
| 28 |
| 17 |
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2013-07-15 | | protein level | | | | | | | 2 |
| 17 |
| 16 |
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2013-06-11 | | protein level | | | | | | | 2 |
| 17 |
| 16 |
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2013-02-12 | | protein level | | | | | | | 2 |
| 7 |
| 27 |
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2012-12-20 | | protein level | | | | | | | 2 |
| 7 |
| 27 |
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2012-10-30 | | protein level | | | | | | | 2 |
| 8 |
| 27 |
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2012-10-07 | | protein level | | | | | | | 2 |
| 8 |
| 14 |
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2012-08-24 | | protein level | | | | | | | 2 |
| 3 |
| 14 |
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2012-07-28 | | protein level | | | | | | | 2 |
| 3 |
| 14 |
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2012-06-08 | | protein level | | | | | | | 2 |
| 4 |
| 14 |
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2012-05-07 | | protein level | | | | | | | 2 |
| 4 |
| 14 |
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2012-04-10 | | protein level | | | | | | | 2 |
| 4 |
| 14 |
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2012-01-13 | | protein level | | | | | | | 2 |
| 6 |
| 14 |
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2011-12-20 | | protein level | | | | | | | 2 |
| 6 |
| 14 |
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2011-11-11 | | protein level | | | | | | | 2 |
| 6 |
| 15 |
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2011-08-23 | | protein level | | | | | | | 2 |
| 6 |
| 15 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-1051583,EBI-714559 |
ARRB2 |
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.positive regulation of DNA biosynthetic process .negative regulation of release of cytochrome c from mitochondria .positive regulation of ERK1 and ERK2 cascade + 35 more... |
.protein complex scaffold .angiotensin receptor binding .ubiquitin protein ligase binding + 3 more... |
.postsynaptic membrane .dendritic spine .cytoplasmic vesicle + 8 more... |
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2 |
EBI-1051583,EBI-743313 |
ARRB1 |
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.positive regulation of histone H4 acetylation .positive regulation of ERK1 and ERK2 cascade .membrane organization + 24 more... |
.transcription regulatory region DNA binding .cysteine-type endopeptidase inhibitor activity involved in apoptotic process .angiotensin receptor binding + 5 more... |
.cytoplasmic vesicle .pseudopodium .cytoplasmic vesicle membrane + 9 more... |
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3 |
EBI-1051583,EBI-1042725 |
AKAP17A |
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.regulation of RNA splicing .B cell activation .RNA splicing + 3 more... |
.protein kinase A binding .poly(A) RNA binding .nucleotide binding |
.nuclear speck .cytoplasm .spliceosomal complex + 2 more... |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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adipose tissue | 233 | |
adrenal gland | 273 | |
ascites | 150 | |
bladder | 133 | |
blood | 98 | |
bone | 83 | |
bone marrow | 164 | |
brain | 156 | |
cervix | 41 | |
connective tissue | 67 | |
ear | 248 | |
embryonic tissue | 145 | |
esophagus | 49 | |
eye | 100 | |
heart | 111 | |
intestine | 56 | |
kidney | 85 | |
larynx | 127 | |
liver | 852 | |
lung | 59 | |
lymph | 22 | |
lymph node | 200 | |
mammary gland | 33 | |
mouth | 120 | |
muscle | 291 | |
nerve | 193 | |
ovary | 59 | |
pancreas | 79 | |
parathyroid | 97 | |
pharynx | 73 | |
pituitary gland | 242 | |
placenta | 113 | |
prostate | 116 | |
salivary gland | 49 | |
skin | 52 | |
spleen | 131 | |
stomach | 104 | |
testis | 121 | |
thymus | 238 | |
thyroid | 193 | |
trachea | 154 | |
uterus | 180 | |
vascular | 309 | |
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Health State | |
Tissues | TPM* | |
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normal | 178 | |
adrenal tumor | 158 | |
bladder carcinoma | 227 | |
breast (mammary gland) tumor | 32 | |
cervical tumor | 57 | |
chondrosarcoma | 96 | |
colorectal tumor | 53 | |
esophageal tumor | 57 | |
gastrointestinal tumor | 143 | |
germ cell tumor | 174 | |
glioma | 27 | |
head and neck tumor | 134 | |
kidney tumor | 159 | |
leukemia | 95 | |
liver tumor | 135 | |
lymphoma | 41 | |
non-neoplasia | 62 | |
ovarian tumor | 52 | |
pancreatic tumor | 95 | |
primitive neuroectodermal tumor of the CNS | 86 | |
prostate cancer | 48 | |
retinoblastoma | 64 | |
skin tumor | 55 | |
soft tissue/muscle tissue tumor | 71 | |
uterine tumor | 155 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 118 | |
embryoid body | 57 | |
blastocyst | 195 | |
neonate | 32 | |
fetus | 136 | |
infant | 127 | |
juvenile | 143 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 41.1 | |
adrenal gland | 56.2 | |
appendix | 64.1 | |
bone marrow | 57.4 | |
cerebral cortex | 47.5 | |
colon | 46.1 | |
duodenum | 48.6 | |
esophagus | 36.9 | |
gallbladder | 48.9 | |
heart muscle | 40.5 | |
kidney | 33.2 | |
liver | 18.5 | |
lung | 64.3 | |
lymph node | 84.1 | |
ovary | 76.6 | |
pancreas | 15.3 | |
placenta | 41.1 | |
prostate | 67.2 | |
salivary gland | 45.3 | |
skin | 61.6 | |
small intestine | 53.4 | |
spleen | 60.6 | |
stomach | 43.9 | |
testis | 62 | |
thyroid gland | 70.3 | |
urinary bladder | 45.3 | |
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Tissues | |
Tissues | Expression level |
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adrenal gland | Medium | |
appendix | Medium | |
bone marrow | Low | |
breast | Medium | |
bronchus | High | |
cerebellum | High | |
cerebral cortex | Medium | |
cervix, uterine | High | |
colon | Medium | |
duodenum | Medium | |
endometrium 1 | Medium | |
endometrium 2 | Medium | |
epididymis | High | |
esophagus | High | |
fallopian tube | High | |
gallbladder | High | |
heart muscle | High | |
hippocampus | Low | |
kidney | High | |
lateral ventricle | Low | |
liver | Medium | |
lung | Medium | |
lymph node | Medium | |
ovary | Medium | |
pancreas | High | |
parathyroid gland | Medium | |
placenta | High | |
prostate | Medium | |
rectum | High | |
salivary gland | High | |
seminal vesicle | Medium | |
skeletal muscle | Medium | |
skin 1 | High | |
skin 2 | High | |
small intestine | High | |
smooth muscle | Medium | |
soft tissue 1 | Medium | |
soft tissue 2 | Medium | |
spleen | Low | |
stomach 1 | High | |
stomach 2 | High | |
testis | High | |
thyroid gland | Medium | |
tonsil | Medium | |
urinary bladder | High | |
vagina | High | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Expression level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*604347, gene) Zinc finger protein 265; ZNF265 | OMIM |
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