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> Protein (NX_O95229)
Protein (NX_O95229)
Protein
Gene SymbolZWINT to neXtProt (NX_O95229)
DescriptionZW10 interactor
Chromosome10
Location10q21.1 (58116989 ~ 58121036) to Ensembl
Sequene Features : Isoforms 2, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of localization in cell
.cell division
.small GTPase mediated signal transduction
  + 3 more...
.protein N-terminus binding .dendrite
.cytosol
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 57 7
2014-09-19protein level
2 43 7
2014-05-27protein level
2 43 7
2014-02-25protein level
2 42 7
2013-12-09protein level
2 37 7
2013-11-01protein level
2 37 7
2013-09-12protein level
2 37 7
2013-08-17protein level
2 37 7
2013-07-15protein level
1 30 1
2013-06-11protein level
1 30 1
2013-02-12protein level
1 13 2
2012-12-20protein level
1 13 2
2012-10-30protein level
1 13 2
2012-10-07protein level
1 13 2
2012-08-24protein level
1 11 2
2012-07-28protein level
1 11 2
2012-06-08protein level
1 11 2
2012-05-07protein level
1 11 2
2012-04-10protein level
1 11 2
2012-01-13protein level
1 6 2
2011-12-20protein level
1 6 2
2011-11-11protein level
1 6 2
2011-08-23protein level
1 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95229-1
3 9 0 31274.1418
NX_O95229-2
1 9 0 25528.077
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1001132,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-1001132,EBI-1001217 ZW10  
  .cell division
.protein localization to kinetochore
.protein transport
  + 11 more...
.centromeric DNA binding .membrane
.cytosol
.kinetochore microtubule
  + 7 more...
3 EBI-1001132,EBI-949378 BECN1  
  .positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood89
bone41
bone marrow82
brain17
cervix144
connective tissue20
embryonic tissue164
esophagus49
eye47
heart22
intestine56
kidney14
liver126
lung14
lymph270
lymph node22
mammary gland72
muscle65
nerve64
ovary78
pancreas14
parathyroid48
pharynx98
placenta17
prostate110
skin80
spleen18
stomach52
testis48
thymus75
uterus68
Health State
TissuesTPM*
normal34
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor96
cervical tumor86
chondrosarcoma48
colorectal tumor53
esophageal tumor57
gastrointestinal tumor50
germ cell tumor49
glioma74
head and neck tumor7
kidney tumor43
leukemia95
liver tumor93
lung tumor9
lymphoma166
non-neoplasia10
ovarian tumor78
pancreatic tumor9
primitive neuroectodermal tumor of the CNS70
prostate cancer182
retinoblastoma86
skin tumor103
soft tissue/muscle tissue tumor111
uterine tumor77
Developmental Stage
TissuesTPM*
adult34
embryoid body85
blastocyst130
fetus66
infant255
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.5
adrenal gland3.2
appendix22.4
bone marrow36.8
cerebral cortex3.9
colon25.5
duodenum16.7
esophagus12.8
gallbladder3.4
heart muscle1.5
kidney5.7
liver4.6
lung3.9
lymph node32.9
ovary2.1
pancreas2.1
placenta15.5
prostate3.5
salivary gland2.5
skin14.1
small intestine17.2
spleen6.1
stomach14.4
testis37.3
thyroid gland5.1
urinary bladder9.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609177, gene) Zw10 interactor; ZWINTOMIM


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