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> Protein (NX_O95273)
Protein (NX_O95273)
Protein
Gene SymbolCCNDBP1 to neXtProt (NX_O95273)
DescriptionCyclin-D1-binding protein 1
Chromosome15
Location15q15.2 (43477316 ~ 43487396) to Ensembl
Sequene Features : Isoforms 4, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 36 3
2014-09-19protein level
4 28 3
2014-05-27protein level
4 28 3
2014-02-25protein level
4 28 3
2013-12-09protein level
4 16 3
2013-11-01protein level
4 16 3
2013-09-12protein level
4 16 2
2013-08-17protein level
4 16 2
2013-07-15protein level
4 10 0
2013-06-11protein level
4 10 0
2013-02-12protein level
4 8 0
2012-12-20protein level
4 9 0
2012-10-30protein level
4 8 0
2012-10-07protein level
4 8 0
2012-08-24protein level
4 8 0
2012-07-28protein level
4 8 0
2012-06-08protein level
4 17 0
2012-05-07protein level
4 14 0
2012-04-10protein level
4 14 0
2012-01-13protein level
4 9 0
2011-12-20protein level
4 10 0
2011-11-11protein level
4 10 0
2011-08-23protein level
4 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95273-1
0 13 0 40236.3436
NX_O95273-2
0 11 0 34531.2551
NX_O95273-3
0 7 0 26020.7932
NX_O95273-4
2 5 0 22698.9218
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748961,EBI-10171534 TMEM120B  
  .N/A .N/A .integral component of membrane
2 EBI-748961,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
3 EBI-748961,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
4 EBI-748961,EBI-2557644 SYF2  
  .embryonic organ development
.gastrulation
.mitotic G2 DNA damage checkpoint
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.nucleus
5 EBI-748961,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
6 EBI-748961,EBI-10193858 PMP2  
  .membrane organization .cholesterol binding
.fatty acid binding
.transporter activity
.extracellular exosome
.cytoplasm
7 EBI-748961,EBI-354101 RPLP0  
  .cellular protein metabolic process
.ribosome biogenesis
.viral transcription
  + 9 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 6 more...
8 EBI-748961,EBI-769645 TCF3  
  .regulation of G1/S transition of mitotic cell cycle
.positive regulation of muscle cell differentiation
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 21 more...
.E-box binding
.vitamin D response element binding
.repressing transcription factor binding
  + 12 more...
.RNA polymerase II transcription factor complex
.protein complex
.cytoplasm
  + 5 more...
9 EBI-748961,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
10 EBI-748961,EBI-1056930 MAP2K2  
  .regulation of early endosome to late endosome transport
.positive regulation of cell motility
.regulation of Golgi inheritance
  + 30 more...
.scaffold protein binding
.protein serine/threonine kinase activator activity
.PDZ domain binding
  + 5 more...
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cell cortex
  + 13 more...
11 EBI-748961,EBI-603329 PSMB10  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 26 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.spermatoproteasome complex
.proteasome core complex
.cytosol
  + 4 more...
12 EBI-748961,EBI-366357 RPL28  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cell body
.cytoplasmic ribonucleoprotein granule
  + 5 more...
13 EBI-748961,EBI-3904463 ATP4B  
  .hydrogen ion transmembrane transport
.transmembrane transport
.ion transmembrane transport
  + 4 more...
.hydrogen:potassium-exchanging ATPase activity .sodium:potassium-exchanging ATPase complex
.plasma membrane
14 EBI-748961,EBI-749129 ZNF136  
  .transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription corepressor activity
.DNA binding
.nucleus
15 EBI-748961,EBI-3911502 RRAD  
  .metabolic process
.small GTPase mediated signal transduction
.GTP binding
.GTPase activity
.plasma membrane
16 EBI-748961,EBI-10216569 NANOS2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.negative regulation of meiotic nuclear division
.germ-line stem cell maintenance
  + 4 more...
.zinc ion binding
.mRNA binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
.cytoplasmic mRNA processing body
17 EBI-748961,EBI-353027 RPS28  
  .cellular protein metabolic process
.ribosomal small subunit biogenesis
.viral transcription
  + 10 more...
.poly(A) RNA binding
.structural constituent of ribosome
.extracellular exosome
.cytosolic small ribosomal subunit
.small ribosomal subunit
  + 2 more...
18 EBI-748961,EBI-3941274 RBP5  
  .N/A .retinol binding
.retinal binding
.retinoid binding
.transporter activity
.extracellular exosome
.cytoplasm
19 EBI-748961,EBI-8796759 AMPD2  
  .energy homeostasis
.nucleobase-containing small molecule metabolic process
.cyclic purine nucleotide metabolic process
  + 5 more...
.metal ion binding
.AMP deaminase activity
.cytosol
20 EBI-748961,EBI-713450 ID2  
  .negative regulation of neural precursor cell proliferation
.regulation of G1/S transition of mitotic cell cycle
.cellular senescence
  + 43 more...
.ion channel binding .protein complex
.microtubule cytoskeleton
.cytosol
  + 5 more...
21 EBI-748961,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
22 EBI-748961,EBI-10234472 ZNF169  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
23 EBI-748961,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
24 EBI-748961,EBI-3920053 ZSCAN26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.nucleic acid binding
.nucleus
25 EBI-748961,EBI-10211248 ZNF394  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
26 EBI-748961,EBI-10244057 C6orf226  
  .N/A .N/A .N/A
27 EBI-748961,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
28 EBI-748961,EBI-6447954 TTC23  
  .N/A .N/A .N/A
29 EBI-748961,EBI-10248413 -  
  .N/A .N/A .N/A
30 EBI-748961,EBI-10249231 NAIF1  
  .regulation of mitochondrial membrane permeability involved in apoptotic process
.negative regulation of cell growth
.N/A .plasma membrane
.mitochondrion
.nucleoplasm
.nucleus
31 EBI-748961,EBI-10255250 CCDC108  
  .N/A .poly(A) RNA binding .integral component of membrane
32 EBI-748961,EBI-2797561 ZNF627  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
33 EBI-748961,EBI-3866859 ARHGAP22  
  .regulation of small GTPase mediated signal transduction
.cell differentiation
.small GTPase mediated signal transduction
  + 3 more...
.GTPase activator activity .focal adhesion
.cytosol
.nucleus
34 EBI-748961,EBI-3246160 TRAPPC5  
  .vesicle-mediated transport .N/A .TRAPP complex
.Golgi apparatus
.endoplasmic reticulum
35 EBI-748961,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
36 EBI-748961,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
37 EBI-748961,EBI-747580 ZNF439  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
38 EBI-748961,EBI-741032 CNNM3  
  .ion transport .N/A .integral component of membrane
.membrane
.plasma membrane
39 EBI-748961,EBI-10270752 ZNF555  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
40 EBI-748961,EBI-742060 TYMSOS  
  .N/A .N/A .N/A
41 EBI-748961,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
42 EBI-748961,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
43 EBI-748961,EBI-594661 COPS5  
  .exosomal secretion
.regulation of IRE1-mediated unfolded protein response
.regulation of cell cycle
  + 8 more...
.metal ion binding
.metallopeptidase activity
.ubiquitin-specific protease activity
  + 2 more...
.perinuclear region of cytoplasm
.cell junction
.COP9 signalosome
  + 5 more...
44 EBI-748961,EBI-1057139 CUL5  
  .intrinsic apoptotic signaling pathway
.calcium ion transmembrane transport
.cytosolic calcium ion homeostasis
  + 7 more...
.ubiquitin protein ligase binding
.calcium channel activity
.receptor activity
.Cul5-RING ubiquitin ligase complex
.plasma membrane
.cytosol
.nucleus
45 EBI-748961,EBI-748111 ZNF707  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
46 EBI-748961,EBI-6658607 RPL39L  
  .spermatogenesis
.translation
.structural constituent of ribosome .cytosolic large ribosomal subunit
47 EBI-748961,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
48 EBI-748961,EBI-745276 ZNF670  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
49 EBI-748961,EBI-2568609 FAM64A  
  .cell division
.mitotic nuclear division
.N/A .cytoplasm
.nucleolus
.nucleus
50 EBI-748961,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
51 EBI-748961,EBI-10303102 C22orf23  
  .N/A .N/A .N/A
52 EBI-748961,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
53 EBI-748961,EBI-747481 IMP3  
  .rRNA processing .poly(A) RNA binding
.snoRNA binding
.Mpp10 complex
.small-subunit processome
.nucleolus
.nucleus
54 EBI-748961,EBI-2371967 MRPL15  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 2 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
.mitochondrion
55 EBI-748961,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
56 EBI-748961,EBI-745404 THAP10  
  .N/A .metal ion binding
.DNA binding
.N/A
57 EBI-748961,EBI-1105361 ZNF230  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
58 EBI-748961,EBI-1105370 ZNF490  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
59 EBI-748961,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
60 EBI-748961,EBI-1053767 GSTK1  
  .oxidation-reduction process
.epithelial cell differentiation
.glutathione metabolic process
.protein disulfide oxidoreductase activity
.receptor binding
.glutathione peroxidase activity
.glutathione transferase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
ascites652
blood171
bone55
bone marrow123
brain51
cervix103
connective tissue13
ear310
embryonic tissue42
esophagus99
eye90
heart22
intestine60
kidney33
liver58
lung86
lymph node111
mammary gland39
mouth30
muscle47
ovary9
pancreas98
pharynx73
placenta229
prostate36
skin85
spleen37
stomach62
testis39
thymus62
thyroid64
tonsil58
trachea38
uterus43
vascular38
Health State
TissuesTPM*
normal85
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma60
colorectal tumor44
esophageal tumor115
gastrointestinal tumor236
germ cell tumor30
glioma9
head and neck tumor29
kidney tumor14
leukemia148
liver tumor41
lung tumor38
lymphoma13
non-neoplasia31
pancreatic tumor95
primitive neuroectodermal tumor of the CNS102
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor66
Developmental Stage
TissuesTPM*
adult79
embryoid body42
blastocyst32
fetus86
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.3
adrenal gland51.4
appendix37.7
bone marrow102.2
cerebral cortex26.3
colon41
duodenum36.8
esophagus43
gallbladder34.6
heart muscle47.5
kidney35.8
liver17.9
lung40.3
lymph node60.8
ovary27.8
pancreas17.8
placenta85.5
prostate33.9
salivary gland33.6
skin29.7
small intestine42.7
spleen46.9
stomach53.1
testis28.4
thyroid gland59.6
urinary bladder53.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
small intestineHigh
smooth muscleLow
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607089, gene) Cyclin d-type-binding protein 1; CCNDBP1OMIM


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