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> Protein (NX_O95297)
Protein (NX_O95297)
Protein
Gene SymbolMPZL1 to neXtProt (NX_O95297)
DescriptionMyelin protein zero-like protein 1
Chromosome1
Location1q24.2 (167690429 ~ 167761156) to Ensembl
Sequene Features : Isoforms 5, Variants 28, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell-cell signaling
.transmembrane receptor protein tyrosine kinase signaling pathway
.structural molecule activity .cell surface
.focal adhesion
.integral component of plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 28 12
2014-09-19protein level
5 25 12
2014-05-27protein level
5 25 12
2014-02-25protein level
5 25 12
2013-12-09protein level
5 20 12
2013-11-01protein level
5 19 11
2013-09-12protein level
5 19 11
2013-08-17protein level
5 19 11
2013-07-15protein level
5 12 11
2013-06-11protein level
5 12 11
2013-02-12protein level
5 6 41
2012-12-20protein level
5 6 41
2012-10-30protein level
5 8 41
2012-10-07protein level
5 8 12
2012-08-24protein level
5 6 12
2012-07-28protein level
5 6 12
2012-06-08protein level
5 10 12
2012-05-07protein level
5 6 12
2012-04-10protein level
4 6 12
2012-01-13protein level
4 5 12
2011-12-20protein level
4 5 12
2011-11-11protein level
4 5 11
2011-08-23protein level
4 5 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95297-1
0 12 0 29063.9409
NX_O95297-2
1 11 0 28962.8935
NX_O95297-3
1 8 0 22746.7165
NX_O95297-4
1 6 0 15937.3652
NX_O95297-5
1 4 0 12346.2613
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-963338,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites225
bladder100
blood32
bone125
bone marrow41
brain65
cervix144
connective tissue107
ear186
embryonic tissue112
esophagus99
eye76
heart55
intestine181
kidney61
liver48
lung74
lymph node66
mammary gland152
mouth423
muscle47
nerve64
ovary88
pancreas79
parathyroid145
pharynx49
pituitary gland181
placenta70
prostate84
skin132
spleen56
stomach135
testis110
thymus50
trachea135
uterus73
vascular77
Health State
TissuesTPM*
normal86
adrenal tumor237
breast (mammary gland) tumor75
cervical tumor173
chondrosarcoma193
colorectal tumor222
esophageal tumor115
gastrointestinal tumor219
germ cell tumor174
glioma205
head and neck tumor186
kidney tumor72
leukemia42
liver tumor52
lung tumor38
non-neoplasia62
ovarian tumor105
pancreatic tumor95
primitive neuroectodermal tumor of the CNS78
prostate cancer144
retinoblastoma129
skin tumor87
soft tissue/muscle tissue tumor23
uterine tumor110
Developmental Stage
TissuesTPM*
adult122
embryoid body214
blastocyst65
neonate32
fetus141
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue67.8
adrenal gland39.2
appendix63.1
bone marrow5.9
cerebral cortex25.4
colon72.8
duodenum43.8
esophagus65.2
gallbladder90.4
heart muscle27.6
kidney29
liver16.2
lung41.4
lymph node41.4
ovary50.8
pancreas16.4
placenta80.3
prostate48.5
salivary gland63.4
skin23.7
small intestine47.3
spleen30.2
stomach55.9
testis67.1
thyroid gland34.6
urinary bladder87
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604376, gene) Myelin protein zero-like 1; MPZL1OMIM


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