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> Protein (NX_O95352)
Protein (NX_O95352)
Protein
Gene SymbolATG7 to neXtProt (NX_O95352)
DescriptionUbiquitin-like modifier-activating enzyme ATG7
Chromosome3
Location3p25.3 (11313995 ~ 11599139) to Ensembl
Sequene Features : Isoforms 3, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of histone H4-K16 acetylation
.regulation of mitochondrion degradation
.cellular response to hyperoxia
  + 33 more...
.protein homodimerization activity
.Atg8 activating enzyme activity
.Atg12 activating enzyme activity
  + 2 more...
.axoneme
.cytosol
.cytoplasm
.pre-autophagosomal structure
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 69 1
2014-09-19protein level
3 44 1
2014-05-27protein level
3 44 1
2014-02-25protein level
3 43 1
2013-12-09protein level
3 35 1
2013-11-01protein level
3 33 1
2013-09-12protein level
3 33 1
2013-08-17protein level
3 33 1
2013-07-15protein level
3 24 0
2013-06-11protein level
3 24 0
2013-02-12protein level
3 13 5
2012-12-20protein level
2 12 4
2012-10-30protein level
2 11 4
2012-10-07protein level
2 11 2
2012-08-24protein level
2 10 2
2012-07-28protein level
2 10 2
2012-06-08protein level
2 10 2
2012-05-07protein level
2 8 2
2012-04-10protein level
2 8 2
2012-01-13protein level
2 4 2
2011-12-20protein level
2 4 2
2011-11-11protein level
2 4 2
2011-08-23protein level
2 4 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95352-1
0 37 0 77909.1053
NX_O95352-2
1 35 0 74953.6038
NX_O95352-3
2 32 0 68573.4634
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-987834,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-987834,EBI-2866589 IRF2  
  .type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.focal adhesion
.cytosol
.cytoplasm
.nucleoplasm
3 EBI-987834,EBI-358607 EEF1D  
  .cellular response to ionizing radiation
.cellular protein metabolic process
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 8 more...
.activating transcription factor binding
.heat shock protein binding
.translation factor activity, RNA binding
  + 3 more...
.eukaryotic translation elongation factor 1 complex
.cytosol
.cytoplasm
  + 2 more...
4 EBI-987834,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
5 EBI-987834,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
6 EBI-987834,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder66
blood57
bone13
bone marrow164
brain74
cervix103
connective tissue53
ear124
embryonic tissue46
eye47
heart122
intestine116
kidney56
liver73
lung68
lymph node22
mammary gland39
mouth45
muscle47
ovary88
pancreas28
parathyroid97
pharynx147
placenta88
prostate58
salivary gland49
skin109
spleen56
stomach52
testis114
thymus12
thyroid42
trachea135
umbilical cord72
uterus43
vascular38
Health State
TissuesTPM*
normal72
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor86
chondrosarcoma12
colorectal tumor124
gastrointestinal tumor67
germ cell tumor56
glioma111
head and neck tumor44
kidney tumor43
leukemia42
liver tumor124
lung tumor48
lymphoma69
non-neoplasia62
ovarian tumor52
pancreatic tumor38
primitive neuroectodermal tumor of the CNS125
prostate cancer57
retinoblastoma21
skin tumor111
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult67
embryoid body85
blastocyst32
neonate96
fetus73
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.4
adrenal gland12.2
appendix27.5
bone marrow20.9
cerebral cortex17
colon15.3
duodenum12.6
esophagus28.4
gallbladder26.8
heart muscle12.9
kidney10.5
liver8.4
lung21
lymph node35.1
ovary14.2
pancreas6.6
placenta20.1
prostate8.4
salivary gland8
skin24.3
small intestine13.2
spleen15
stomach13.6
testis27.9
thyroid gland24
urinary bladder31.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608760, gene) Autophagy 7, s. cerevisiae, homolog of; ATG7OMIM


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