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> Protein (NX_O95363)
Protein (NX_O95363)
Protein
Gene SymbolFARS2 to neXtProt (NX_O95363)
DescriptionPhenylalanine--tRNA ligase, mitochondrial
Chromosome6
Location6p25.1 (5261277 ~ 5771813) to Ensembl
Sequene Features : Isoforms 1, Variants 65, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 65 1
2014-09-19protein level
1 46 1
2014-05-27protein level
1 46 1
2014-02-25protein level
1 46 1
2013-12-09protein level
1 35 1
2013-11-01protein level
1 32 1
2013-09-12protein level
1 32 1
2013-08-17protein level
1 32 1
2013-07-15protein level
1 20 1
2013-06-11protein level
1 20 1
2013-02-12protein level
1 10 1
2012-12-20protein level
1 10 1
2012-10-30protein level
1 11 1
2012-10-07protein level
1 11 1
2012-08-24protein level
1 11 1
2012-07-28protein level
1 11 1
2012-06-08protein level
1 13 1
2012-05-07protein level
1 10 1
2012-04-10protein level
1 10 1
2012-01-13protein level
1 10 1
2011-12-20protein level
1 10 1
2011-11-11protein level
1 10 1
2011-08-23protein level
1 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95363-1
21 0 0 52323.379
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2513774,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
2 EBI-2513774,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
3 EBI-2513774,EBI-742404 RCBTB2  
  .positive regulation of GTPase activity .Ran guanyl-nucleotide exchange factor activity .N/A
4 EBI-2513774,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
5 EBI-2513774,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
6 EBI-2513774,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
7 EBI-2513774,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
8 EBI-2513774,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
9 EBI-2513774,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
10 EBI-2513774,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
11 EBI-2513774,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
12 EBI-2513774,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
13 EBI-2513774,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
14 EBI-2513774,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
15 EBI-2513774,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
16 EBI-2513774,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
17 EBI-2513774,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
18 EBI-2513774,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
19 EBI-2513774,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
20 EBI-2513774,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
21 EBI-2513774,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood81
bone97
bone marrow41
brain22
cervix41
connective tissue127
embryonic tissue9
eye4
heart78
intestine17
kidney71
liver14
lung29
mammary gland26
ovary49
pancreas28
parathyroid48
pharynx49
pituitary gland60
placenta14
prostate10
skin9
stomach10
testis6
umbilical cord145
uterus8
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma24
colorectal tumor26
germ cell tumor26
glioma27
kidney tumor14
leukemia95
lung tumor29
non-neoplasia20
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS157
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor135
uterine tumor11
Developmental Stage
TissuesTPM*
adult35
blastocyst16
neonate64
fetus44
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.2
adrenal gland12.9
appendix12.2
bone marrow9.8
cerebral cortex7.6
colon13.1
duodenum8.1
esophagus15.2
gallbladder11.7
heart muscle16.8
kidney16
liver10.2
lung13.5
lymph node16.6
ovary10
pancreas6.9
placenta9.9
prostate8.6
salivary gland8.3
skin10.9
small intestine8.9
spleen11.4
stomach9.8
testis14.8
thyroid gland21.7
urinary bladder16.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611592, gene) Phenylalanyl-trna synthetase 2, mitochondrial; FARS2OMIM


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2014-2019 (C) Yonsei Proteome Research Center