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> Protein (NX_O95376)
Protein (NX_O95376)
Protein
Gene SymbolARIH2 to neXtProt (NX_O95376)
DescriptionE3 ubiquitin-protein ligase ARIH2
Chromosome3
Location3p21.31 (48956254 ~ 49023815) to Ensembl
Sequene Features : Isoforms 1, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein targeting to mitochondrion
.hematopoietic stem cell proliferation
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nucleic acid binding
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 45 4
2014-09-19protein level
1 26 4
2014-05-27protein level
1 26 4
2014-02-25protein level
1 26 4
2013-12-09protein level
1 20 4
2013-11-01protein level
1 16 3
2013-09-12protein level
1 16 3
2013-08-17protein level
1 16 3
2013-07-15protein level
1 13 1
2013-06-11protein level
1 13 1
2013-02-12protein level
1 4 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 4 1
2012-10-07protein level
1 4 1
2012-08-24protein level
1 4 1
2012-07-28protein level
1 4 1
2012-06-08protein level
1 7 1
2012-05-07protein level
1 6 1
2012-04-10protein level
1 6 1
2012-01-13protein level
1 11 1
2011-12-20protein level
1 11 1
2011-11-11protein level
1 11 1
2011-08-23protein level
1 11 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95376-1
22 0 0 57780.9724
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711158,EBI-2129974 UBE2L6  
  .innate immune response
.negative regulation of type I interferon production
.ISG15-protein conjugation
  + 5 more...
.ISG15 transferase activity
.ligase activity
.ubiquitin-protein transferase activity
.cytosol
.nucleoplasm
2 EBI-711158,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-711158,EBI-711173 UBE2L3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to glucocorticoid stimulus
.cellular response to steroid hormone stimulus
  + 11 more...
.ubiquitin-protein transferase activator activity
.ubiquitin conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.extracellular exosome
.cytoplasm
.nucleus
.ubiquitin ligase complex
4 EBI-711158,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-711158,EBI-743729 UGP2  
  .cellular glucuronidation
.small molecule metabolic process
.glucose 1-phosphate metabolic process
  + 6 more...
.metal ion binding
.identical protein binding
.pyrimidine ribonucleotide binding
  + 2 more...
.extracellular exosome
.cytosol
.nucleus
6 EBI-711158,EBI-1057139 CUL5  
  .intrinsic apoptotic signaling pathway
.calcium ion transmembrane transport
.cytosolic calcium ion homeostasis
  + 7 more...
.ubiquitin protein ligase binding
.calcium channel activity
.receptor activity
.Cul5-RING ubiquitin ligase complex
.plasma membrane
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland151
ascites100
bladder66
blood98
bone125
bone marrow61
brain107
cervix123
connective tissue87
embryonic tissue136
esophagus49
eye191
heart189
intestine163
kidney75
larynx42
liver170
lung95
lymph270
lymph node89
mammary gland72
mouth136
muscle300
nerve64
ovary128
pancreas79
parathyroid97
pharynx24
pituitary gland60
placenta91
prostate79
salivary gland296
skin175
spleen149
stomach177
testis181
thymus62
thyroid128
trachea96
umbilical cord217
uterus94
vascular116
Health State
TissuesTPM*
normal118
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor173
chondrosarcoma108
colorectal tumor257
esophageal tumor57
gastrointestinal tumor160
germ cell tumor178
glioma121
head and neck tumor141
kidney tumor87
leukemia116
liver tumor177
lung tumor107
lymphoma193
non-neoplasia93
ovarian tumor131
pancreatic tumor85
primitive neuroectodermal tumor of the CNS110
prostate cancer67
retinoblastoma172
skin tumor167
soft tissue/muscle tissue tumor167
uterine tumor66
Developmental Stage
TissuesTPM*
adult132
embryoid body142
blastocyst130
neonate193
fetus107
infant127
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.6
adrenal gland28
appendix34.2
bone marrow52.5
cerebral cortex27.4
colon34.5
duodenum27.3
esophagus30.4
gallbladder29.4
heart muscle47.3
kidney28.5
liver20.6
lung38.7
lymph node38.8
ovary33
pancreas17.5
placenta33.3
prostate27.2
salivary gland23.4
skin25.5
small intestine25.6
spleen33.7
stomach32.3
testis43.5
thyroid gland41.5
urinary bladder31.2
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*605615, gene) Ariadne, drosophila, homolog of, 2; ARIH2OMIM


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