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> Protein (NX_O95379)
Protein (NX_O95379)
Protein
Gene SymbolTNFAIP8 to neXtProt (NX_O95379)
DescriptionTumor necrosis factor alpha-induced protein 8
Chromosome5
Location5q23.1 (118604387 ~ 118735383) to Ensembl
Sequene Features : Isoforms 4, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.defense response to Gram-positive bacterium
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
.interleukin-1 beta production
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 18 0
2014-09-19protein level
4 14 0
2014-05-27protein level
4 14 0
2014-02-25protein level
3 14 0
2013-12-09protein level
3 10 0
2013-11-01protein level
3 10 0
2013-09-12protein level
3 10 0
2013-08-17protein level
3 10 0
2013-07-15protein level
3 7 0
2013-06-11protein level
3 7 0
2013-02-12protein level
3 3 0
2012-12-20protein level
3 4 0
2012-10-30protein level
3 6 0
2012-10-07protein level
3 6 0
2012-08-24protein level
3 6 0
2012-07-28protein level
3 6 0
2012-06-08protein level
3 1 0
2012-05-07protein level
3 1 0
2012-04-10protein level
3 1 0
2012-01-13protein level
3 1 0
2011-12-20protein level
3 1 0
2011-11-11protein level
3 1 0
2011-08-23protein level
3 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95379-1
2 6 0 22988.8005
NX_O95379-2
1 6 0 22033.4147
NX_O95379-3
1 6 0 21863.3097
NX_O95379-4
2 6 0 24369.7191
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1049336,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-1049336,EBI-769401 INO80E  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
3 EBI-1049336,EBI-740711 TIFA  
  .I-kappaB kinase/NF-kappaB signaling .N/A .N/A
4 EBI-1049336,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
5 EBI-1049336,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
6 EBI-1049336,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder133
blood204
bone55
bone marrow102
brain10
cervix41
connective tissue40
embryonic tissue42
esophagus49
eye23
heart11
intestine30
kidney28
larynx42
liver29
lung5
lymph22
lymph node89
mouth15
ovary9
pancreas18
pharynx245
placenta113
prostate5
salivary gland98
skin9
spleen112
stomach31
testis13
thymus125
tonsil58
trachea96
uterus30
Health State
TissuesTPM*
normal43
bladder carcinoma113
cervical tumor57
chondrosarcoma12
colorectal tumor17
esophageal tumor57
gastrointestinal tumor8
germ cell tumor15
glioma18
head and neck tumor14
leukemia158
liver tumor31
lung tumor9
lymphoma41
non-neoplasia82
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma86
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult37
embryoid body42
blastocyst16
neonate64
fetus19
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue59.7
adrenal gland5
appendix61.3
bone marrow41.5
cerebral cortex1.6
colon17.6
duodenum14.2
esophagus27.7
gallbladder19
heart muscle6.5
kidney11
liver5.9
lung15.9
lymph node116.6
ovary3.1
pancreas5.3
placenta53.1
prostate15.9
salivary gland8.3
skin27.1
small intestine16.9
spleen56.9
stomach29.7
testis5.3
thyroid gland23.4
urinary bladder42.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612111, gene) Tumor necrosis factor-alpha-induced protein 8; TNFAIP8OMIM


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