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> Protein (NX_O95400)
Protein (NX_O95400)
Protein
Gene SymbolCD2BP2 to neXtProt (NX_O95400)
DescriptionCD2 antigen cytoplasmic tail-binding protein 2
Chromosome16
Location16p11.2 (30362087 ~ 30366682) to Ensembl
Sequene Features : Isoforms 1, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of phosphatase activity
.gene expression
.RNA splicing
  + 2 more...
.ribonucleoprotein complex binding .cytoplasm
.U5 snRNP
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 37 7
2014-09-19protein level
1 31 7
2014-05-27protein level
1 31 7
2014-02-25protein level
1 30 6
2013-12-09protein level
1 27 6
2013-11-01protein level
1 27 6
2013-09-12protein level
1 27 6
2013-08-17protein level
1 27 6
2013-07-15protein level
1 21 5
2013-06-11protein level
1 21 5
2013-02-12protein level
1 12 6
2012-12-20protein level
1 12 6
2012-10-30protein level
1 12 6
2012-10-07protein level
1 12 6
2012-08-24protein level
1 8 6
2012-07-28protein level
1 8 6
2012-06-08protein level
1 8 6
2012-05-07protein level
1 8 6
2012-04-10protein level
1 8 6
2012-01-13protein level
1 4 6
2011-12-20protein level
1 4 6
2011-11-11protein level
1 4 5
2011-08-23protein level
1 4 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95400-1
15 0 0 37623.1287
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-768015,EBI-536755 PRPF6  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.RNA splicing
  + 5 more...
.androgen receptor binding
.poly(A) RNA binding
.ribonucleoprotein complex binding
  + 2 more...
.catalytic step 2 spliceosome
.U4/U6 snRNP
.U4/U6 x U5 tri-snRNP complex
  + 6 more...
2 EBI-768015,EBI-3912464 CD2  
  .positive regulation of interleukin-8 secretion
.positive regulation of interferon-gamma secretion
.leukocyte migration
  + 11 more...
.receptor binding
.receptor activity
.anchored component of plasma membrane
.cell surface
.cytoplasmic side of plasma membrane
  + 5 more...
3 EBI-768015,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
4 EBI-768015,EBI-356283 PPP1CC  
  .cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 10 more...
.protein N-terminus binding
.metal ion binding
.poly(A) RNA binding
  + 4 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.protein complex
  + 11 more...
5 EBI-768015,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
6 EBI-768015,EBI-746539 TXNL4A  
  .cell division
.gene expression
.RNA splicing
  + 4 more...
.N/A .U4/U6 x U5 tri-snRNP complex
.U5 snRNP
.spliceosomal complex
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites50
blood24
bone111
bone marrow20
brain55
cervix103
connective tissue46
embryonic tissue108
eye105
heart22
intestine60
kidney61
liver38
lung146
lymph270
lymph node100
mammary gland66
mouth30
muscle9
ovary137
pancreas126
pharynx49
placenta49
prostate42
salivary gland246
skin71
spleen18
stomach73
testis18
thymus12
thyroid85
tonsil58
uterus129
vascular19
Health State
TissuesTPM*
normal51
adrenal tumor158
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma120
colorectal tumor44
gastrointestinal tumor75
germ cell tumor53
glioma149
head and neck tumor89
kidney tumor101
leukemia52
liver tumor52
lung tumor214
lymphoma193
non-neoplasia41
ovarian tumor105
pancreatic tumor161
primitive neuroectodermal tumor of the CNS220
prostate cancer57
retinoblastoma150
skin tumor103
soft tissue/muscle tissue tumor71
uterine tumor155
Developmental Stage
TissuesTPM*
adult63
embryoid body128
blastocyst97
fetus26
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.4
adrenal gland29.3
appendix34.7
bone marrow14.7
cerebral cortex26.1
colon27.9
duodenum25.2
esophagus18.8
gallbladder22.9
heart muscle21.7
kidney24.8
liver15.1
lung27.8
lymph node33.6
ovary29.2
pancreas12.5
placenta22.2
prostate25.2
salivary gland18.4
skin18.6
small intestine22.5
spleen29.6
stomach25.3
testis20.4
thyroid gland26.3
urinary bladder24.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604470, gene) Cd2 antigen-binding protein 2; CD2BP2OMIM


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