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> Protein (NX_O95466)
Protein (NX_O95466)
Protein
Gene SymbolFMNL1 to neXtProt (NX_O95466)
DescriptionFormin-like protein 1
Chromosome17
Location17q21.31 (43298811 ~ 43324687) to Ensembl
Sequene Features : Isoforms 3, Variants 105, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.actin filament severing
.cortical actin cytoskeleton organization
.regulation of cell shape
  + 2 more...
.actin filament binding
.Rac GTPase binding
.GTPase activating protein binding
.extracellular exosome
.phagocytic vesicle
.bleb
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 105 9
2014-09-19protein level
3 82 9
2014-05-27protein level
3 82 9
2014-02-25protein level
3 81 9
2013-12-09protein level
3 61 9
2013-11-01protein level
3 58 8
2013-09-12protein level
3 58 8
2013-08-17protein level
3 58 8
2013-07-15protein level
3 36 8
2013-06-11protein level
3 36 8
2013-02-12protein level
3 18 15
2012-12-20protein level
3 15 15
2012-10-30protein level
3 21 15
2012-10-07protein level
3 21 5
2012-08-24protein level
3 20 5
2012-07-28protein level
3 20 5
2012-06-08protein level
3 4 5
2012-05-07protein level
2 19 5
2012-04-10protein level
2 19 5
2012-01-13protein level
2 12 5
2011-12-20protein level
2 12 5
2011-11-11protein level
2 12 4
2011-08-23protein level
2 12 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95466-1
1 45 4 121776.3637
NX_O95466-2
1 44 5 122331.661
NX_O95466-3
2 45 4 128253.5266
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-720020,EBI-1051034 SRGAP2  
  .negative regulation of neuron migration
.dendritic spine development
.regulation of small GTPase mediated signal transduction
  + 9 more...
.Rac GTPase binding
.protein homodimerization activity
.GTPase activator activity
.phagocytic vesicle
.postsynaptic membrane
.dendritic spine head
  + 7 more...
2 EBI-10191924,EBI-740641 HMG20A  
  .negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood343
bone83
bone marrow61
brain32
cervix20
connective tissue26
eye14
heart22
intestine4
larynx42
liver4
lung65
lymph270
lymph node66
mammary gland13
mouth15
muscle9
ovary19
pancreas56
pituitary gland60
placenta28
prostate47
skin4
spleen74
stomach20
testis2
thymus87
tonsil117
uterus4
Health State
TissuesTPM*
normal35
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma72
gastrointestinal tumor16
germ cell tumor3
head and neck tumor22
leukemia285
liver tumor10
lung tumor126
lymphoma221
non-neoplasia31
ovarian tumor26
pancreatic tumor104
prostate cancer57
retinoblastoma21
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult50
fetus8
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.3
adrenal gland8.3
appendix83.9
bone marrow214.6
cerebral cortex13.8
colon9.6
duodenum11.9
esophagus9.5
gallbladder26.7
heart muscle6.6
kidney3.5
liver5.1
lung34.3
lymph node78
ovary2
pancreas3.4
placenta14.8
prostate7.5
salivary gland14.1
skin8.5
small intestine14.4
spleen79.8
stomach18.1
testis6
thyroid gland4.9
urinary bladder33.4
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
lungMedium
lymph nodeMedium
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604656, gene) Formin-like; FMNLOMIM


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