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> Protein (NX_O95602)
Protein (NX_O95602)
Protein
Gene SymbolPOLR1A to neXtProt (NX_O95602)
DescriptionDNA-directed RNA polymerase I subunit RPA1
Chromosome2
Location2p11.2 (86247339 ~ 86333278) to Ensembl
Sequene Features : Isoforms 1, Variants 187, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 4 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytoplasm
.DNA-directed RNA polymerase I complex
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 187 12
2014-09-19protein level
1 140 12
2014-05-27protein level
1 140 12
2014-02-25protein level
1 138 12
2013-12-09protein level
1 99 12
2013-11-01protein level
1 97 9
2013-09-12protein level
1 97 9
2013-08-17protein level
1 97 9
2013-07-15protein level
1 63 4
2013-06-11protein level
1 63 4
2013-02-12protein level
1 32 4
2012-12-20protein level
1 32 4
2012-10-30protein level
1 46 4
2012-10-07protein level
1 46 4
2012-08-24protein level
1 29 4
2012-07-28protein level
1 29 4
2012-06-08protein level
1 41 4
2012-05-07protein level
1 41 4
2012-04-10protein level
1 41 4
2012-01-13protein level
1 31 4
2011-12-20protein level
1 31 4
2011-11-11protein level
1 31 3
2011-08-23protein level
1 31 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95602-1
85 0 1 194686.5041
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359472,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-359472,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
3 EBI-359472,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
4 EBI-359472,EBI-355441 POLR1B  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.nucleologenesis
  + 7 more...
.metal ion binding
.ribonucleoside binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytoplasm
.DNA-directed RNA polymerase I complex
.nucleolus
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder33
blood57
bone13
bone marrow20
brain22
cervix41
connective tissue13
embryonic tissue42
eye47
heart67
intestine38
kidney18
larynx42
liver19
lung23
lymph67
lymph node77
mammary gland52
mouth60
muscle37
pancreas18
pharynx24
placenta21
prostate10
salivary gland49
skin37
spleen18
stomach20
testis16
thymus12
thyroid64
trachea57
uterus30
Health State
TissuesTPM*
normal24
adrenal tumor158
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor33
germ cell tumor26
glioma37
head and neck tumor74
leukemia74
liver tumor41
lung tumor29
lymphoma41
non-neoplasia10
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma107
skin tumor55
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult22
embryoid body42
blastocyst48
neonate32
fetus46
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6
adrenal gland4.3
appendix5.9
bone marrow3.2
cerebral cortex6.9
colon6.4
duodenum3.9
esophagus5.5
gallbladder3.4
heart muscle5.8
kidney5.7
liver3.1
lung3.9
lymph node4.9
ovary6
pancreas2.6
placenta8.5
prostate4.8
salivary gland3.5
skin6.1
small intestine3.4
spleen4.2
stomach4.5
testis7.9
thyroid gland5.7
urinary bladder6.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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