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> Protein (NX_O95630)
Protein (NX_O95630)
Protein
Gene SymbolSTAMBP to neXtProt (NX_O95630)
DescriptionSTAM-binding protein
Chromosome2
Location2p13.1 (74056086 ~ 74100786) to Ensembl
Sequene Features : Isoforms 2, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of Ras protein signal transduction
.negative regulation of neuron apoptotic process
.protein deubiquitination
  + 4 more...
.metal ion binding
.protein domain specific binding
.metallopeptidase activity
.ubiquitin-specific protease activity
.extracellular exosome
.cleavage furrow
.plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 54 8
2014-09-19protein level
1 43 8
2014-05-27protein level
1 42 8
2014-02-25protein level
1 43 8
2013-12-09protein level
1 33 8
2013-11-01protein level
1 32 8
2013-09-12protein level
1 32 8
2013-08-17protein level
1 26 8
2013-07-15protein level
1 17 5
2013-06-11protein level
1 17 5
2013-02-12protein level
1 8 5
2012-12-20protein level
1 8 5
2012-10-30protein level
1 13 5
2012-10-07protein level
1 13 5
2012-08-24protein level
1 12 5
2012-07-28protein level
1 12 5
2012-06-08protein level
1 13 5
2012-05-07protein level
1 10 5
2012-04-10protein level
1 10 5
2012-01-13protein level
1 3 5
2011-12-20protein level
1 3 5
2011-11-11protein level
1 3 5
2011-08-23protein level
1 3 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95630-1
5 12 0 48046.42
NX_O95630-2
1 12 0 39571.4444
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396676,EBI-4324970 SMAD6  
  .negative regulation of pathway-restricted SMAD protein phosphorylation
.fat cell differentiation
.response to estrogen
  + 14 more...
.type I activin receptor binding
.R-SMAD binding
.I-SMAD binding
  + 10 more...
.protein complex
.cytosol
.cytoplasm
  + 2 more...
2 EBI-396676,EBI-373258 STAM2  
  .membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
3 EBI-396676,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-396676,EBI-2118090 CHMP1B  
  .regulation of mitotic spindle assembly
.cell division
.establishment of protein localization
  + 7 more...
.protein domain specific binding .extracellular exosome
.late endosome membrane
.membrane coat
  + 2 more...
5 EBI-396676,EBI-752333 STAM  
  .regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.membrane organization
  + 6 more...
.SH3/SH2 adaptor activity .early endosome membrane
.cytosol
6 EBI-396676,EBI-1057156 CHMP1A  
  .regulation of mitotic spindle assembly
.cell division
.negative regulation of transcription, DNA-templated
  + 12 more...
.protein homodimerization activity
.protein domain specific binding
.zinc ion binding
.metallopeptidase activity
.extracellular exosome
.nuclear matrix
.endomembrane system
  + 4 more...
7 EBI-396676,EBI-751303 CHMP5  
  .regulation of mitotic spindle assembly
.multivesicular body sorting pathway
.membrane organization
  + 12 more...
.N/A .extracellular exosome
.endosome membrane
.cytosol
.nucleus
8 EBI-396676,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
9 EBI-396676,EBI-2118119 CHMP3  
  .positive regulation of viral release from host cell
.negative regulation of viral release from host cell
.membrane organization
  + 13 more...
.ubiquitin-specific protease binding
.protein homodimerization activity
.phosphatidylcholine binding
.extracellular exosome
.late endosome membrane
.cytoplasmic membrane-bounded vesicle
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder133
blood57
bone153
brain21
cervix41
connective tissue46
ear124
embryonic tissue56
esophagus49
eye76
heart44
intestine125
kidney75
larynx42
liver58
lung62
lymph45
lymph node89
mammary gland72
muscle75
ovary78
pancreas23
parathyroid48
pituitary gland60
placenta49
prostate47
skin80
spleen18
stomach20
testis11
thymus12
thyroid107
trachea38
uterus81
vascular19
Health State
TissuesTPM*
normal54
bladder carcinoma284
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma169
colorectal tumor88
esophageal tumor57
gastrointestinal tumor42
germ cell tumor26
glioma37
head and neck tumor29
kidney tumor43
leukemia84
liver tumor62
lung tumor48
lymphoma96
non-neoplasia72
ovarian tumor91
pancreatic tumor28
primitive neuroectodermal tumor of the CNS94
prostate cancer57
retinoblastoma129
skin tumor39
soft tissue/muscle tissue tumor79
uterine tumor22
Developmental Stage
TissuesTPM*
adult66
embryoid body85
blastocyst65
fetus73
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.4
adrenal gland14.4
appendix17.7
bone marrow9.8
cerebral cortex25.7
colon25.5
duodenum23.3
esophagus28.2
gallbladder21
heart muscle19.9
kidney22.3
liver13.4
lung17
lymph node22.8
ovary20.2
pancreas7.5
placenta18.8
prostate24.5
salivary gland17.5
skin19.6
small intestine23.2
spleen17
stomach19.6
testis22.9
thyroid gland27.8
urinary bladder24.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606247, gene) Stam-binding protein; STAMBPOMIM
2(%614261, phenotype) Microcephaly-capillary malformation syndrome; MICCAPOMIM


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