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> Protein (NX_O95644)
Protein (NX_O95644)
Protein
Gene SymbolNFATC1 to neXtProt (NX_O95644)
DescriptionNuclear factor of activated T-cells, cytoplasmic 1
Chromosome18
Location18q23 (77155856 ~ 77289325) to Ensembl
Sequene Features : Isoforms 10, Variants 163, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.innate immune response
  + 9 more...
.mitogen-activated protein kinase p38 binding
.transcription regulatory region DNA binding
.FK506 binding
  + 6 more...
.cytosol
.cytoplasm
.transcription factor complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 163 4
2014-09-19protein level
10 117 4
2014-05-27protein level
10 117 4
2014-02-25protein level
9 117 4
2013-12-09protein level
9 80 4
2013-11-01protein level
9 77 4
2013-09-12protein level
9 77 4
2013-08-17protein level
7 77 4
2013-07-15protein level
7 51 4
2013-06-11protein level
7 51 4
2013-02-12protein level
7 23 28
2012-12-20protein level
7 20 28
2012-10-30protein level
7 25 7
2012-10-07protein level
7 25 1
2012-08-24protein level
7 24 1
2012-07-28protein level
7 24 1
2012-06-08protein level
7 8 1
2012-05-07protein level
9 8 1
2012-04-10protein level
9 8 1
2012-01-13protein level
9 8 1
2011-12-20protein level
9 8 2
2011-11-11protein level
9 8 2
2011-08-23protein level
9 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95644-1
0 40 1 101179.2014
NX_O95644-10
0 33 1 77327.4534
NX_O95644-11
0 31 1 76421.7883
NX_O95644-17
1 17 0 38601.8486
NX_O95644-2
0 32 1 77736.6613
NX_O95644-3
0 30 1 76830.9962
NX_O95644-4
0 36 1 88707.1417
NX_O95644-5
0 34 1 87801.4766
NX_O95644-6
0 38 1 100273.5363
NX_O95644-8
0 29 1 74229.858
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6907210,EBI-539828 OGT  
  .regulation of gluconeogenesis involved in cellular glucose homeostasis
.histone H3-K4 trimethylation
.cellular response to retinoic acid
  + 21 more...
.protein O-GlcNAc transferase activity
.protein N-acetylglucosaminyltransferase activity
.acetylglucosaminyltransferase activity
  + 2 more...
.MLL5-L complex
.plasma membrane
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone13
brain4
cervix41
connective tissue6
embryonic tissue14
eye9
heart78
intestine12
kidney9
lung29
lymph node178
mammary gland26
mouth15
ovary49
pancreas14
parathyroid145
placenta3
prostate15
salivary gland49
spleen74
testis25
thymus25
tonsil58
uterus12
vascular19
Health State
TissuesTPM*
normal7
bladder carcinoma56
cervical tumor57
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor8
germ cell tumor15
glioma9
head and neck tumor14
leukemia63
lymphoma110
ovarian tumor26
pancreatic tumor9
prostate cancer28
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult6
embryoid body14
blastocyst32
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.4
adrenal gland3.6
appendix11.9
bone marrow3.4
cerebral cortex2.1
colon3.9
duodenum3
esophagus5.4
gallbladder14.8
heart muscle7.5
kidney2.6
liver2.4
lung10.4
lymph node27.8
ovary5
pancreas4.2
placenta4.5
prostate4.6
salivary gland2.5
skin4.7
small intestine3.3
spleen16.4
stomach6.5
testis12.2
thyroid gland5.4
urinary bladder6.7
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowMedium
breastMedium
bronchusLow
cerebral cortexMedium
endometrium 1Medium
endometrium 2Low
fallopian tubeLow
heart muscleLow
kidneyMedium
lungLow
lymph nodeHigh
nasopharynxLow
placentaLow
skin 1Low
soft tissue 1Medium
spleenLow
stomach 1Low
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600489, gene) Nuclear factor of activated t cells, cytoplasmic, calcineurin-dependentOMIM


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