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> Protein (NX_O95751)
Protein (NX_O95751)
Protein
Gene SymbolLDOC1 to neXtProt (NX_O95751)
DescriptionProtein LDOC1
ChromosomeX
LocationXq27.1 (140269934 ~ 140271310) to Ensembl
Sequene Features : Isoforms 1, Variants 23, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell proliferation .N/A .nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 23 2
2014-09-19protein level
1 16 2
2014-05-27protein level
1 16 2
2014-02-25protein level
1 16 2
2013-12-09protein level
1 16 2
2013-11-01protein level
1 16 2
2013-09-12protein level
1 16 2
2013-08-17protein level
1 16 2
2013-07-15protein level
1 8 2
2013-06-11protein level
1 8 2
2013-02-12protein level
1 0 0
2012-12-20protein level
1 0 0
2012-10-30protein level
1 0 0
2012-10-07protein level
1 0 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95751-1
6 0 0 16957.0664
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740738,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-740738,EBI-487024 ABLIM1  
  .positive regulation of transcription from RNA polymerase II promoter
.cilium assembly
.lamellipodium assembly
  + 4 more...
.zinc ion binding
.actin binding
.lamellipodium
.actin cytoskeleton
.cytoplasm
.stress fiber
3 EBI-740738,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
4 EBI-740738,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
5 EBI-740738,EBI-711802 ATP6V1G1  
  .phagosome maturation
.transmembrane transport
.interaction with host
  + 4 more...
.ATPase binding
.hydrogen-exporting ATPase activity, phosphorylative mechanism
.extracellular exosome
.vacuolar proton-transporting V-type ATPase complex
.plasma membrane
  + 2 more...
6 EBI-740738,EBI-726527 TNNT1  
  .negative regulation of muscle contraction
.slow-twitch skeletal muscle fiber contraction
.muscle filament sliding
.skeletal muscle contraction
.tropomyosin binding .troponin complex
.cytosol
7 EBI-740738,EBI-744510 FOSL1  
  .positive regulation of DNA-templated transcription, initiation
.placenta blood vessel development
.response to cAMP
  + 22 more...
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.neuron projection
.presynaptic membrane
.cytosol
  + 2 more...
8 EBI-740738,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
9 EBI-740738,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
10 EBI-740738,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
11 EBI-740738,EBI-746484 NRIP1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.circadian regulation of gene expression
  + 6 more...
.androgen receptor binding
.glucocorticoid receptor binding
.nuclear hormone receptor binding
  + 4 more...
.cell junction
.nuclear speck
.nucleolus
  + 3 more...
12 EBI-740738,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
13 EBI-740738,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
14 EBI-740738,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
15 EBI-740738,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
16 EBI-740738,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
17 EBI-740738,EBI-6447954 TTC23  
  .N/A .N/A .N/A
18 EBI-740738,EBI-10251462 ZNF774  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
19 EBI-740738,EBI-710457 DPPA4  
  .lung-associated mesenchyme development
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
20 EBI-740738,EBI-2858265 PEG10  
  .negative regulation of transforming growth factor beta receptor signaling pathway
.cell differentiation
.apoptotic process
.poly(A) RNA binding
.zinc ion binding
.DNA binding
.cytoplasm
.nucleus
21 EBI-740738,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
22 EBI-740738,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
23 EBI-740738,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
24 EBI-740738,EBI-748128 CTNNBL1  
  .positive regulation of apoptotic process
.somatic diversification of immunoglobulins
.gene expression
  + 3 more...
.enzyme binding .membrane
.cytoplasm
.spliceosomal complex
  + 3 more...
25 EBI-740738,EBI-359932 DPF2  
  .apoptotic signaling pathway
.apoptotic process
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.intracellular membrane-bounded organelle
.centrosome
.cytoplasm
  + 2 more...
26 EBI-740738,EBI-726510 LENG1  
  .N/A .N/A .N/A
27 EBI-740738,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
28 EBI-740738,EBI-473181 BARD1  
  .protein K6-linked ubiquitination
.negative regulation of protein export from nucleus
.positive regulation of protein catabolic process
  + 9 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase binding
  + 4 more...
.BRCA1-A complex
.intracellular membrane-bounded organelle
.BRCA1-BARD1 complex
  + 5 more...
29 EBI-740738,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
30 EBI-740738,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
31 EBI-740738,EBI-347633 ZNF408  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.identical protein binding
.DNA binding
.nucleus
32 EBI-740738,EBI-399266 MEAF6  
  .histone H3-K14 acetylation
.histone H4-K12 acetylation
.histone H4-K8 acetylation
  + 5 more...
.N/A .MOZ/MORF histone acetyltransferase complex
.NuA4 histone acetyltransferase complex
.centrosome
  + 3 more...
33 EBI-740738,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
34 EBI-740738,EBI-3258000 TBC1D7  
  .negative regulation of cilium assembly
.activation of GTPase activity
.response to growth factor
  + 2 more...
.Rab GTPase binding
.GTPase activator activity
.ciliary basal body
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
35 EBI-740738,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood8
bone41
brain46
cervix20
connective tissue13
embryonic tissue42
esophagus49
eye38
heart33
intestine4
kidney23
liver19
lung14
mammary gland39
nerve64
ovary59
pancreas51
pharynx24
pituitary gland121
prostate10
skin4
testis2
thyroid42
tonsil411
uterus12
vascular19
Health State
TissuesTPM*
normal24
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma48
esophageal tumor57
glioma65
head and neck tumor22
kidney tumor58
liver tumor10
lung tumor29
non-neoplasia10
ovarian tumor39
pancreatic tumor85
primitive neuroectodermal tumor of the CNS39
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult20
embryoid body71
blastocyst16
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.3
adrenal gland27.8
appendix6.3
cerebral cortex48.1
colon5.6
duodenum2.6
esophagus15.5
gallbladder17.2
heart muscle5.2
kidney22.6
liver2.7
lung13.1
lymph node7.7
ovary45.1
pancreas10.9
placenta1.1
prostate30.5
salivary gland40.5
skin26.1
small intestine2.8
spleen9.5
stomach8.9
testis8.9
thyroid gland49.9
urinary bladder20.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300402, gene) Leucine zipper, downregulated in cancer 1; LDOC1OMIM


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