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> Protein (NX_O95777)
Protein (NX_O95777)
Protein
Gene SymbolLSM8 to neXtProt (NX_O95777)
DescriptionU6 snRNA-associated Sm-like protein LSm8
Chromosome7
Location7q31.31 (117824086 ~ 117832878) to Ensembl
Sequene Features : Isoforms 1, Variants 1, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mRNA splicing, via spliceosome .poly(A) RNA binding
.U6 snRNA 3'-end binding
.U6 snRNA binding
.U4/U6 x U5 tri-snRNP complex
.spliceosomal complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 1 1
2014-09-19protein level
1 11 1
2014-05-27protein level
1 11 1
2014-02-25protein level
1 11 1
2013-12-09protein level
1 10 1
2013-11-01protein level
1 10 1
2013-09-12protein level
1 10 1
2013-08-17protein level
1 10 1
2013-07-15protein level
1 7 1
2013-06-11protein level
1 7 1
2013-02-12protein level
1 1 1
2012-12-20protein level
1 1 1
2012-10-30protein level
1 1 1
2012-10-07protein level
1 1 1
2012-08-24protein level
1 1 1
2012-07-28protein level
1 1 1
2012-06-08protein level
1 1 1
2012-05-07protein level
1 1 1
2012-04-10protein level
1 1 1
2012-01-13protein level
1 1 1
2011-12-20protein level
1 1 1
2011-11-11protein level
1 1 1
2011-08-23protein level
1 1 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95777-1
6 0 0 10396.2614
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347779,EBI-348239 LSM3  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA processing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.cytosol
.nucleus
2 EBI-347779,EBI-347416 LSM2  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.Ral GTPase binding
.U6 snRNA binding
.catalytic step 2 spliceosome
.cytosol
.nucleoplasm
3 EBI-347779,EBI-372521 LSM4  
  .activation of mitophagy in response to mitochondrial depolarization
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 4 more...
.poly(A) RNA binding .small nuclear ribonucleoprotein complex
.cytosol
.U6 snRNP
.spliceosomal complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood40
bone27
bone marrow82
brain36
connective tissue26
ear124
embryonic tissue79
eye28
heart11
intestine38
kidney47
liver14
lung32
lymph22
lymph node122
mammary gland19
muscle9
ovary29
pancreas37
parathyroid97
placenta10
prostate116
salivary gland49
skin33
spleen18
stomach20
testis27
thymus75
thyroid21
uterus68
Health State
TissuesTPM*
normal41
adrenal tumor79
breast (mammary gland) tumor32
chondrosarcoma48
colorectal tumor53
gastrointestinal tumor16
germ cell tumor45
glioma46
kidney tumor58
leukemia21
liver tumor20
lymphoma27
non-neoplasia51
pancreatic tumor57
primitive neuroectodermal tumor of the CNS7
prostate cancer163
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor77
Developmental Stage
TissuesTPM*
adult40
embryoid body42
blastocyst48
neonate64
fetus64
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.1
adrenal gland16.2
appendix30.4
bone marrow31.5
cerebral cortex12.6
colon22.6
duodenum21.9
esophagus13.9
gallbladder19.3
heart muscle13
kidney15.1
liver9.9
lung17.4
lymph node40.8
ovary18.6
pancreas7.9
placenta16.9
prostate20.6
salivary gland11.4
skin17.1
small intestine21
spleen26.7
stomach22.9
testis17
thyroid gland22
urinary bladder20.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
bone marrowLow
breastLow
bronchusHigh
cerebellumMedium
cerebral cortexLow
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607288, gene) Lsm8 protein; LSM8OMIM


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