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> Protein (NX_O95863)
Protein (NX_O95863)
Protein
Gene SymbolSNAI1 to neXtProt (NX_O95863)
DescriptionZinc finger protein SNAI1
Chromosome20
Location20q13.13 (48599536 ~ 48605423) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 16
2014-09-19protein level
1 28 16
2014-05-27protein level
1 28 16
2014-02-25protein level
1 28 16
2013-12-09protein level
1 28 16
2013-11-01protein level
1 27 16
2013-09-12protein level
1 27 16
2013-08-17protein level
1 27 16
2013-07-15protein level
1 18 16
2013-06-11protein level
1 18 16
2013-02-12protein level
1 6 11
2012-12-20protein level
1 6 11
2012-10-30protein level
1 5 11
2012-10-07protein level
1 5 10
2012-08-24protein level
1 5 10
2012-07-28protein level
1 5 10
2012-06-08protein level
1 21 10
2012-05-07protein level
1 17 10
2012-04-10protein level
1 17 10
2012-01-13protein level
1 16 10
2011-12-20protein level
1 16 10
2011-11-11protein level
1 16 10
2011-08-23protein level
1 16 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95863-1
9 0 2 29064.3379
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1045459,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
2 EBI-1045459,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-1045459,EBI-355676 PARP1  
  .positive regulation of transcription regulatory region DNA binding
.cellular response to superoxide
.protein poly-ADP-ribosylation
  + 22 more...
.NAD binding
.protein N-terminus binding
.poly(A) RNA binding
  + 7 more...
.membrane
.nucleolus
.transcription factor complex
  + 3 more...
4 EBI-1045459,EBI-77797 ACTN2  
  .negative regulation of protein localization to cell surface
.positive regulation of potassium ion transmembrane transporter activity
.negative regulation of potassium ion transmembrane transporter activity
  + 13 more...
.titin Z domain binding
.FATZ binding
.protein dimerization activity
  + 8 more...
.extracellular exosome
.dendritic spine
.pseudopodium
  + 9 more...
5 EBI-1045459,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
6 EBI-1045459,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
7 EBI-1045459,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-1045459,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
9 EBI-1045459,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-1045459,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
11 EBI-1045459,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
12 EBI-1045459,EBI-307461 BTRC  
  .cellular response to organic cyclic compound
.regulation of proteasomal protein catabolic process
.branching involved in mammary gland duct morphogenesis
  + 28 more...
.ligase activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites125
blood40
bone55
bone marrow41
brain11
connective tissue26
embryonic tissue9
eye38
intestine12
kidney9
lung23
mammary gland6
ovary19
pancreas4
placenta45
skin4
stomach20
testis9
uterus8
vascular96
Health State
TissuesTPM*
normal14
breast (mammary gland) tumor10
chondrosarcoma48
gastrointestinal tumor59
germ cell tumor15
kidney tumor14
leukemia21
lung tumor9
non-neoplasia41
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS220
retinoblastoma64
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult21
embryoid body14
blastocyst16
fetus8
infant255
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland5.4
appendix3.8
bone marrow2.8
cerebral cortex1.1
colon1.6
esophagus1.2
gallbladder16.9
heart muscle3
kidney1.9
liver3
lung4.2
lymph node2
pancreas2.5
placenta7.3
prostate1.7
salivary gland1.6
skin1.5
spleen2.6
testis2.8
thyroid gland8.5
urinary bladder8.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604238, gene) Snail, drosophila, homolog of, 1; SNAI1OMIM


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