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> Protein (NX_O95881)
Protein (NX_O95881)
Protein
Gene SymbolTXNDC12 to neXtProt (NX_O95881)
DescriptionThioredoxin domain-containing protein 12
Chromosome1
Location1p32.3 (52485803 ~ 52521843) to Ensembl
Sequene Features : Isoforms 1, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell redox homeostasis .protein-disulfide reductase (glutathione) activity .endoplasmic reticulum lumen
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 24 1
2014-09-19protein level
1 21 1
2014-05-27protein level
1 21 1
2014-02-25protein level
1 21 1
2013-12-09protein level
1 16 1
2013-11-01protein level
1 15 1
2013-09-12protein level
1 15 1
2013-08-17protein level
1 15 1
2013-07-15protein level
1 9 1
2013-06-11protein level
1 9 1
2013-02-12protein level
1 7 1
2012-12-20protein level
1 7 1
2012-10-30protein level
1 9 1
2012-10-07protein level
1 9 1
2012-08-24protein level
1 7 1
2012-07-28protein level
1 7 1
2012-06-08protein level
1 10 1
2012-05-07protein level
1 10 1
2012-04-10protein level
1 10 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 7 1
2011-11-11protein level
1 7 1
2011-08-23protein level
1 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95881-1
8 0 0 19193.5262
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2564581,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-2564581,EBI-746999 KLHL2  
  .protein ubiquitination .actin binding .Cul3-RING ubiquitin ligase complex
.lamellipodium
.actin cytoskeleton
  + 3 more...
3 EBI-2564581,EBI-744081 SGTB  
  .N/A .N/A .N/A
4 EBI-2564581,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites75
bladder33
blood130
bone223
bone marrow20
brain90
cervix82
connective tissue120
ear62
embryonic tissue122
eye105
heart11
intestine125
kidney90
liver58
lung92
lymph90
lymph node66
mammary gland72
mouth60
muscle28
nerve128
ovary157
pancreas131
parathyroid242
pharynx98
pituitary gland60
placenta116
prostate89
salivary gland197
skin180
spleen37
stomach219
testis124
thymus37
thyroid85
tonsil58
uterus73
vascular38
Health State
TissuesTPM*
normal87
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor86
chondrosarcoma193
colorectal tumor195
gastrointestinal tumor194
germ cell tumor106
glioma102
head and neck tumor104
kidney tumor87
leukemia84
liver tumor93
lung tumor87
lymphoma110
non-neoplasia62
ovarian tumor157
pancreatic tumor123
primitive neuroectodermal tumor of the CNS196
prostate cancer105
retinoblastoma193
skin tumor287
soft tissue/muscle tissue tumor183
uterine tumor66
Developmental Stage
TissuesTPM*
adult106
embryoid body171
blastocyst113
neonate32
fetus111
infant212
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.4
adrenal gland27.8
appendix27.2
bone marrow17.8
cerebral cortex16.1
colon34.5
duodenum24.8
esophagus17.5
gallbladder27.9
heart muscle15.9
kidney23.7
liver19.4
lung23.6
lymph node27.4
ovary26.1
pancreas15.3
placenta28.2
prostate23.5
salivary gland23.3
skin14
small intestine25
spleen24
stomach29.4
testis25.2
thyroid gland30.2
urinary bladder30.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609448, gene) Thioredoxin domain-containing protein 12; TXNDC12OMIM


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