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> Protein (NX_O95985)
Protein (NX_O95985)
Protein
Gene SymbolTOP3B to neXtProt (NX_O95985)
DescriptionDNA topoisomerase 3-beta-1
Chromosome22
Location22q11.22 (22311397 ~ 22337213) to Ensembl
Sequene Features : Isoforms 3, Variants 84, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chromosome segregation
.DNA topological change
.poly(A) RNA binding
.DNA topoisomerase type I activity
.DNA topoisomerase activity
.DNA binding
.nucleoplasm
.nucleus
.condensed chromosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 84 2
2014-09-19protein level
3 60 2
2014-05-27protein level
3 60 2
2014-02-25protein level
3 60 2
2013-12-09protein level
3 44 2
2013-11-01protein level
3 41 0
2013-09-12protein level
3 41 0
2013-08-17protein level
3 41 0
2013-07-15protein level
3 30 0
2013-06-11protein level
3 30 0
2013-02-12protein level
3 18 0
2012-12-20protein level
3 20 0
2012-10-30protein level
3 24 0
2012-10-07protein level
3 24 0
2012-08-24protein level
3 18 0
2012-07-28protein level
3 18 0
2012-06-08protein level
3 1 0
2012-05-07protein level
3 1 0
2012-04-10protein level
3 1 0
2012-01-13protein level
3 1 0
2011-12-20protein level
3 6 0
2011-11-11protein level
3 6 0
2011-08-23protein level
3 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95985-1
7 36 1 96598.8809
NX_O95985-2
1 36 1 82069.9392
NX_O95985-3
0 36 1 79786.8865
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373403,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
2 EBI-373403,EBI-7082156 SPRED2  
  .regulation of protein deacetylation
.positive regulation of DNA damage response, signal transduction by p53 class mediator
.negative regulation of peptidyl-threonine phosphorylation
  + 2 more...
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.stem cell factor receptor binding
.transport vesicle membrane
.plasma membrane
.cytoplasm
.nucleoplasm
3 EBI-373403,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
4 EBI-373403,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
5 EBI-373403,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
6 EBI-373403,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood65
bone marrow82
brain55
cervix41
connective tissue20
embryonic tissue70
esophagus148
eye38
heart22
intestine47
kidney14
liver34
lung14
lymph node55
mammary gland59
mouth136
muscle37
nerve64
ovary9
pancreas23
pharynx24
pituitary gland121
placenta7
prostate26
skin56
spleen37
testis36
thymus489
trachea77
uterus51
vascular58
Health State
TissuesTPM*
normal39
adrenal tumor79
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma24
colorectal tumor17
esophageal tumor173
gastrointestinal tumor16
germ cell tumor26
glioma37
head and neck tumor67
leukemia95
liver tumor72
lymphoma13
non-neoplasia31
ovarian tumor13
pancreatic tumor47
primitive neuroectodermal tumor of the CNS149
prostate cancer38
skin tumor71
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult27
embryoid body42
blastocyst97
neonate32
fetus46
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.5
adrenal gland7.9
appendix13.3
bone marrow15.6
cerebral cortex7.2
colon8.1
duodenum11.4
esophagus7.6
gallbladder11.2
heart muscle5.9
kidney6.1
liver4.8
lung9.7
lymph node18.1
ovary8.7
pancreas3.2
placenta9.1
prostate9.3
salivary gland6.6
skin14.9
small intestine9.6
spleen19.4
stomach9.9
testis10.6
thyroid gland7.3
urinary bladder10.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*603582, gene) Topoisomerase, dna, iii, beta; TOP3BOMIM


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