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> Protein (NX_O95994)
Protein (NX_O95994)
Protein
Gene SymbolAGR2 to neXtProt (NX_O95994)
DescriptionAnterior gradient protein 2 homolog
Chromosome7
Location7p21.1 (16831435 ~ 16873057) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mucus secretion
.lung goblet cell differentiation
.dystroglycan binding .endoplasmic reticulum
.mitochondrion
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 1
2014-09-19protein level
1 13 1
2014-05-27protein level
1 13 1
2014-02-25protein level
1 13 1
2013-12-09protein level
1 11 1
2013-11-01protein level
1 10 1
2013-09-12protein level
1 10 1
2013-08-17protein level
1 10 1
2013-07-15protein level
1 7 1
2013-06-11protein level
1 7 1
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 4 0
2012-10-07protein level
1 4 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 4 0
2012-05-07protein level
1 4 0
2012-04-10protein level
1 4 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95994-1
7 0 1 19966.5579
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712648,EBI-3905109 FABP2  
  .small molecule metabolic process
.triglyceride catabolic process
.digestion
.fatty acid binding
.transporter activity
.cytosol
2 EBI-712648,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
3 EBI-712648,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
4 EBI-712648,EBI-739990 POM121  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.N/A .nuclear membrane
.endoplasmic reticulum membrane
.nuclear pore
.nuclear envelope
5 EBI-712648,EBI-751933 NUP62CL  
  .protein transport .structural constituent of nuclear pore .nuclear pore
6 EBI-712648,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites602
bladder200
bone marrow61
cervix61
eye43
heart44
intestine517
kidney18
larynx127
liver68
lung62
mammary gland277
mouth151
muscle9
ovary19
pancreas641
pharynx245
pituitary gland60
placenta31
prostate195
stomach2173
testis6
trachea115
uterus38
Health State
TissuesTPM*
normal67
bladder carcinoma113
breast (mammary gland) tumor322
cervical tumor57
colorectal tumor755
gastrointestinal tumor1147
germ cell tumor18
head and neck tumor37
leukemia42
liver tumor72
lung tumor19
non-neoplasia93
ovarian tumor13
pancreatic tumor1266
prostate cancer154
uterine tumor99
Developmental Stage
TissuesTPM*
adult146
fetus34
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.9
adrenal gland1.6
appendix123.7
cerebral cortex1.1
colon877.4
duodenum629.8
esophagus28.2
gallbladder413.2
kidney8.4
lung76.4
pancreas15.1
placenta4.6
prostate330.5
salivary gland53.9
skin2.5
small intestine540.3
stomach1350
thyroid gland13.6
urinary bladder254.3
Tissues
TissuesExpression level
appendixHigh
breastLow
bronchusHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
fallopian tubeHigh
gallbladderHigh
kidneyMedium
lungMedium
nasopharynxHigh
pancreasMedium
placentaMedium
prostateHigh
rectumHigh
seminal vesicleHigh
skin 1Low
small intestineHigh
stomach 1High
stomach 2High
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606358, gene) Anterior gradient 2, xenopus, homolog of; AGR2OMIM


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