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> Protein (NX_O95996)
Protein (NX_O95996)
Protein
Gene SymbolAPC2 to neXtProt (NX_O95996)
DescriptionAdenomatous polyposis coli protein 2
Chromosome19
Location19p13.3 (1446300 ~ 1473243) to Ensembl
Sequene Features : Isoforms 3, Variants 119, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of canonical Wnt signaling pathway
.negative regulation of catenin import into nucleus
.Wnt signaling pathway
.beta-catenin binding .perinuclear region of cytoplasm
.lamellipodium membrane
.catenin complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 119 0
2014-09-19protein level
3 86 0
2014-05-27protein level
3 85 0
2014-02-25protein level
3 85 0
2013-12-09protein level
3 54 0
2013-11-01protein level
3 50 0
2013-09-12protein level
3 50 0
2013-08-17protein level
3 50 0
2013-07-15protein level
3 37 0
2013-06-11protein level
3 37 0
2013-02-12protein level
3 22 0
2012-12-20protein level
3 22 0
2012-10-30protein level
3 30 0
2012-10-07protein level
3 30 0
2012-08-24protein level
3 28 0
2012-07-28protein level
3 28 0
2012-06-08protein level
3 40 0
2012-05-07protein level
3 38 0
2012-04-10protein level
3 38 0
2012-01-13protein level
3 28 0
2011-12-20protein level
3 28 0
2011-11-11protein level
3 28 0
2011-08-23protein level
3 28 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95996-1
1 115 1 243798.0731
NX_O95996-2
1 100 1 213668.2375
NX_O95996-3
1 115 1 243670.0149
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053045,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
2 EBI-1053045,EBI-1004115 MAPRE1  
  .positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
3 EBI-1053045,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain107
eye43
intestine8
kidney4
liver4
lung11
lymph node11
mouth30
nerve257
spleen18
testis2
Health State
TissuesTPM*
normal36
germ cell tumor7
glioma251
head and neck tumor14
leukemia42
liver tumor10
non-neoplasia41
primitive neuroectodermal tumor of the CNS15
Developmental Stage
TissuesTPM*
adult11
fetus100
infant170
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland2.7
cerebral cortex34.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*612034, gene) Apc2 gene; APC2OMIM


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