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> Protein (NX_O95999)
Protein (NX_O95999)
Protein
Gene SymbolBCL10 to neXtProt (NX_O95999)
DescriptionB-cell lymphoma/leukemia 10
Chromosome1
Location1p22.3 (85731931 ~ 85742773) to Ensembl
Sequene Features : Isoforms 1, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway
.cellular response to mechanical stimulus
.T cell apoptotic process
  + 29 more...
.NF-kappaB binding
.protein self-association
.protein kinase B binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 52 3
2014-09-19protein level
1 47 3
2014-05-27protein level
1 47 3
2014-02-25protein level
1 47 3
2013-12-09protein level
1 40 3
2013-11-01protein level
1 39 3
2013-09-12protein level
1 39 3
2013-08-17protein level
1 39 3
2013-07-15protein level
1 32 2
2013-06-11protein level
1 32 2
2013-02-12protein level
1 25 2
2012-12-20protein level
1 25 2
2012-10-30protein level
1 28 2
2012-10-07protein level
1 28 2
2012-08-24protein level
1 22 2
2012-07-28protein level
1 23 2
2012-06-08protein level
1 34 2
2012-05-07protein level
1 34 2
2012-04-10protein level
1 34 2
2012-01-13protein level
1 32 2
2011-12-20protein level
1 32 2
2011-11-11protein level
1 32 2
2011-08-23protein level
1 31 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O95999-1
9 0 0 26235.2504
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-958922,EBI-958997 BCL3  
  .maintenance of protein location in nucleus
.regulation of DNA binding
.spleen development
  + 29 more...
.protein binding, bridging
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.perinuclear region of cytoplasm
.intercellular bridge
.protein complex
  + 5 more...
2 EBI-958922,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
3 EBI-958922,EBI-295351 PRKCZ  
  .positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
4 EBI-958922,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
5 EBI-958922,EBI-7006141 CARD11  
  .positive regulation of NF-kappaB transcription factor activity
.T cell receptor signaling pathway
.nucleotide phosphorylation
  + 13 more...
.CARD domain binding
.guanylate kinase activity
.extracellular exosome
.membrane raft
.plasma membrane
  + 3 more...
6 EBI-958922,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
7 EBI-958922,EBI-1047372 MALT1  
  .protein oligomerization
.nuclear export
.positive regulation of NF-kappaB transcription factor activity
  + 20 more...
.protein self-association
.peptidase activity
.signal transducer activity
  + 2 more...
.perinuclear region of cytoplasm
.protein complex
.CBM complex
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood24
bone55
bone marrow20
brain6
cervix41
connective tissue26
ear62
embryonic tissue4
esophagus49
eye4
heart11
intestine17
kidney9
liver19
lung8
lymph node77
mammary gland72
mouth15
muscle18
nerve64
ovary19
pancreas4
skin18
spleen18
stomach20
testis18
trachea38
uterus25
vascular154
Health State
TissuesTPM*
normal19
bladder carcinoma56
cervical tumor57
chondrosarcoma48
colorectal tumor8
esophageal tumor57
gastrointestinal tumor16
germ cell tumor37
leukemia21
liver tumor10
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult21
embryoid body14
neonate32
fetus19
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland7.1
appendix11.8
bone marrow11.4
cerebral cortex3.4
colon24.3
duodenum11.2
esophagus14.7
gallbladder17.9
heart muscle3.3
kidney7.1
liver5.3
lung8
lymph node10.8
ovary6.1
pancreas3.5
placenta7.5
prostate5.8
salivary gland4.6
skin6.6
small intestine13.2
spleen8.6
stomach13
testis5.7
thyroid gland7.2
urinary bladder14
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#156240, phenotype) Mesothelioma, malignant; MESOMOMIM
2(*603517, gene) B-cell cll/lymphoma 10; BCL10OMIM
3mucosa-associated lymphoid tissue lymphomaCGP


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