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> Protein (NX_P00519)
Protein (NX_P00519)
Protein
Gene SymbolABL1 to neXtProt (NX_P00519)
DescriptionTyrosine-protein kinase ABL1
Chromosome9
Location9q34.12 (133589333 ~ 133763062) to Ensembl
Sequene Features : Isoforms 2, Variants 187, PTMs 40 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 187 40
2014-09-19protein level
2 147 40
2014-05-27protein level
2 147 40
2014-02-25protein level
2 89 35
2013-12-09protein level
2 63 35
2013-11-01protein level
2 63 35
2013-09-12protein level
2 63 35
2013-08-17protein level
2 63 35
2013-07-15protein level
2 63 35
2013-06-11protein level
2 63 35
2013-02-12protein level
2 63 69
2012-12-20protein level
2 64 69
2012-10-30protein level
2 69 69
2012-10-07protein level
2 69 35
2012-08-24protein level
2 69 35
2012-07-28protein level
2 69 35
2012-06-08protein level
2 89 35
2012-05-07protein level
2 48 35
2012-04-10protein level
2 48 35
2012-01-13protein level
2 46 35
2011-12-20protein level
2 46 35
2011-11-11protein level
2 46 35
2011-08-23protein level
2 46 31
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P00519-1
1 49 6 122795.9839
NX_P00519-2
2 49 6 124877.0822
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-375543,EBI-6092730 MSH5  
  .chiasma assembly
.homologous chromosome segregation
.reciprocal meiotic recombination
.mismatch repair
.mismatched DNA binding
.DNA-dependent ATPase activity
.ATP binding
.synaptonemal complex
2 EBI-375543,EBI-1751761 PRICKLE3  
  .N/A .zinc ion binding .N/A
3 EBI-375543,EBI-1222956 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
4 EBI-375543,EBI-1752674 SLC22A3  
  .activation of mitophagy in response to mitochondrial depolarization
.transmembrane transport
.histamine uptake
  + 6 more...
.toxin transporter activity
.quaternary ammonium group transmembrane transporter activity
.organic cation transmembrane transporter activity
.dopamine transmembrane transporter activity
.membrane
.integral component of plasma membrane
.plasma membrane
5 EBI-375543,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
6 EBI-375543,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
7 EBI-375543,EBI-300173 ITGB2  
  .positive regulation of NF-kappaB transcription factor activity
.leukocyte migration
.activated T cell proliferation
  + 26 more...
.cell adhesion molecule binding
.metal ion binding
.ICAM-3 receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.receptor complex
  + 6 more...
8 EBI-375543,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
9 EBI-375543,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
10 EBI-375543,EBI-876302 TOP1  
  .response to drug
.embryonic cleavage
.circadian regulation of gene expression
  + 8 more...
.poly(A) RNA binding
.DNA topoisomerase type II (ATP-hydrolyzing) activity
.DNA topoisomerase type I activity
  + 3 more...
.perikaryon
.replication fork protection complex
.nucleolus
  + 3 more...
11 EBI-375543,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
12 EBI-375543,EBI-625518 VAV1  
  .apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
13 EBI-375543,EBI-2804728 MUC1  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of histone H4 acetylation
.cellular protein metabolic process
  + 9 more...
.transcription cofactor activity
.p53 binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.vesicle
.apical plasma membrane
  + 4 more...
14 EBI-375543,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
15 EBI-375543,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
16 EBI-375543,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
17 EBI-375543,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
18 EBI-375543,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
19 EBI-375543,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
20 EBI-375543,EBI-298181 SOS2  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
21 EBI-375543,EBI-366017 RIN1  
  .negative regulation of synaptic plasticity
.associative learning
.memory
  + 2 more...
.GTPase activator activity .neuronal cell body
.dendrite
.plasma membrane
  + 2 more...
22 EBI-375543,EBI-976876 RAPGEF1  
  .negative regulation of neural precursor cell proliferation
.cellular response to nerve growth factor stimulus
.regulation of cell junction assembly
  + 17 more...
.Rap guanyl-nucleotide exchange factor activity .cytosol
.early endosome
.endosome
23 EBI-375543,EBI-489954 FLNC  
  .muscle fiber development
.cell junction assembly
.ankyrin binding
.cytoskeletal protein binding
.costamere
.sarcolemma
.Z disc
  + 6 more...
24 EBI-375543,EBI-4402156 SHB  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .plasma membrane
.cytosol
25 EBI-375543,EBI-1050422 LRRK1  
  .positive regulation of intracellular signal transduction
.negative regulation of peptidyl-tyrosine phosphorylation
.positive regulation of peptidyl-tyrosine phosphorylation
  + 3 more...
.metal ion binding
.identical protein binding
.GTP binding
  + 2 more...
.mitochondrion
.cytoplasm
26 EBI-375543,EBI-7016840 CDON  
  .positive regulation of neural precursor cell proliferation
.embryonic retina morphogenesis in camera-type eye
.positive regulation of muscle cell differentiation
  + 17 more...
.N/A .integral component of membrane
.plasma membrane
27 EBI-375543,EBI-995373 MAVS  
  .regulation of peroxisome organization
.positive regulation of IP-10 production
.positive regulation of chemokine (C-C motif) ligand 5 production
  + 22 more...
.CARD domain binding
.protein kinase binding
.signal transducer activity
.mitochondrial membrane
.integral component of membrane
.peroxisomal membrane
  + 2 more...
28 EBI-375543,EBI-1043236 RIMS1  
  .positive regulation of excitatory postsynaptic membrane potential
.positive regulation of dendrite extension
.positive regulation of inhibitory postsynaptic membrane potential
  + 17 more...
.metal ion binding
.poly(A) RNA binding
.GTPase regulator activity
.Rab GTPase binding
.presynaptic active zone
.presynaptic membrane
.cell junction
  + 2 more...
29 EBI-375543,EBI-375446 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
30 EBI-375543,EBI-881 MAP4K1  
  .protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
31 EBI-375543,EBI-433642 SORBS1  
  .positive regulation of establishment of protein localization to plasma membrane
.focal adhesion assembly
.positive regulation of lipid biosynthetic process
  + 9 more...
.cytoskeletal protein binding
.insulin receptor binding
.SH3/SH2 adaptor activity
.actin binding
.membrane raft
.nuclear matrix
.focal adhesion
  + 10 more...
32 EBI-375543,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
33 EBI-375543,EBI-1220811 TLN2  
  .cell adhesion
.cell-cell junction assembly
.cytoskeletal anchoring at plasma membrane
.structural constituent of cytoskeleton
.structural molecule activity
.actin binding
.synapse
.actin cytoskeleton
.focal adhesion
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood16
bone69
bone marrow41
brain53
cervix103
connective tissue20
embryonic tissue79
eye76
heart67
intestine56
kidney66
larynx85
liver29
lung65
lymph45
lymph node44
mammary gland52
mouth75
muscle206
ovary118
pancreas42
pharynx24
pituitary gland121
placenta7
prostate68
skin180
spleen56
testis52
thymus12
thyroid64
tonsil58
trachea57
umbilical cord145
uterus107
Health State
TissuesTPM*
normal51
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma84
colorectal tumor79
gastrointestinal tumor16
germ cell tumor45
glioma74
head and neck tumor74
kidney tumor116
leukemia42
liver tumor31
lung tumor165
lymphoma27
non-neoplasia51
ovarian tumor118
pancreatic tumor57
primitive neuroectodermal tumor of the CNS86
prostate cancer28
retinoblastoma43
skin tumor271
soft tissue/muscle tissue tumor207
uterine tumor110
Developmental Stage
TissuesTPM*
adult60
embryoid body100
blastocyst130
neonate32
fetus48
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.1
adrenal gland23.1
appendix24.8
bone marrow14.5
cerebral cortex17.9
colon33.6
duodenum22
esophagus33.2
gallbladder41
heart muscle18.2
kidney20.6
liver4.8
lung22.1
lymph node17.6
ovary37.3
pancreas13
placenta25.6
prostate25.3
salivary gland21.6
skin15.4
small intestine22
spleen23.2
stomach17.9
testis23.9
thyroid gland36.9
urinary bladder41.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasLow
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*189980, gene) Abelson murine leukemia viral oncogene homolog 1; ABL1OMIM
2(#608232, phenotype) Leukemia, chronic myeloid; CMLOMIM
3chronic myeloid leukemia;acute lymphocytic leukemia;T-cell acute lymphoblastic leukemiaCGP


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