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> Protein (NX_P00533)
Protein (NX_P00533)
Protein
Gene SymbolEGFR to neXtProt (NX_P00533)
DescriptionEpidermal growth factor receptor
Chromosome7
Location7p11.2 (55086714 ~ 55324313) to Ensembl
Sequene Features : Isoforms 4, Variants 590, PTMs 73 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 590 73
2014-09-19protein level
4 512 73
2014-05-27protein level
4 512 73
2014-02-25protein level
4 509 73
2013-12-09protein level
4 496 71
2013-11-01protein level
4 484 70
2013-09-12protein level
4 484 70
2013-08-17protein level
4 484 70
2013-07-15protein level
4 350 69
2013-06-11protein level
4 350 69
2013-02-12protein level
4 350 176
2012-12-20protein level
4 346 176
2012-10-30protein level
4 348 176
2012-10-07protein level
4 348 78
2012-08-24protein level
4 348 78
2012-07-28protein level
4 348 78
2012-06-08protein level
4 79 78
2012-05-07protein level
4 79 77
2012-04-10protein level
4 79 77
2012-01-13protein level
4 73 77
2011-12-20protein level
4 73 77
2011-11-11protein level
4 72 72
2011-08-23protein level
4 72 72
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P00533-1
25 34 3 134189.8731
NX_P00533-2
0 23 0 44634.4122
NX_P00533-3
3 34 0 77260.7713
NX_P00533-4
1 34 0 69182.0099
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297353,EBI-81694 APBB1  
  .negative regulation of thymidylate synthase biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 17 more...
.proline-rich region binding
.histone binding
.transcription factor binding
  + 2 more...
.synapse
.growth cone
.lamellipodium
  + 4 more...
2 EBI-297353,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
3 EBI-297353,EBI-641107 PIK3C2B  
  .cell chemotaxis
.phosphatidylinositol phosphorylation
.innate immune response
  + 10 more...
.phosphatidylinositol binding
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.1-phosphatidylinositol-3-kinase activity
  + 2 more...
.endocytic vesicle
.phosphatidylinositol 3-kinase complex
.plasma membrane
  + 4 more...
4 EBI-297353,EBI-356594 IRS4  
  .regulation of lipid metabolic process
.positive regulation of signal transduction
.insulin receptor signaling pathway
.signal transduction
.phosphatidylinositol 3-kinase binding
.insulin receptor binding
.SH3/SH2 adaptor activity
.signal transducer activity
.intracellular membrane-bounded organelle
.plasma membrane
.cytosol
5 EBI-297353,EBI-448680 AURKA  
  .neuron projection extension
.positive regulation of oocyte maturation
.negative regulation of spindle checkpoint
  + 21 more...
.histone serine kinase activity
.protein kinase binding
.ATP binding
  + 3 more...
.meiotic spindle
.mitotic spindle
.spindle midzone
  + 14 more...
6 EBI-297353,EBI-1222766 LAT  
  .regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of protein kinase activity
  + 15 more...
.protein kinase binding
.SH3/SH2 adaptor activity
.membrane raft
.mast cell granule
.integral component of membrane
  + 4 more...
7 EBI-297353,EBI-973722 TLR2  
  .cellular response to triacyl bacterial lipopeptide
.cellular response to diacyl bacterial lipopeptide
.cellular response to peptidoglycan
  + 58 more...
.lipoteichoic acid binding
.protein heterodimerization activity
.peptidoglycan binding
  + 6 more...
.cell body
.cell projection
.Toll-like receptor 2-Toll-like receptor 6 protein complex
  + 6 more...
8 EBI-297353,EBI-701927 CTNND1  
  .negative regulation of canonical Wnt signaling pathway
.vascular endothelial growth factor receptor signaling pathway
.cell-cell junction organization
  + 8 more...
.cadherin binding
.receptor binding
.extracellular exosome
.synapse
.dendritic spine
  + 9 more...
9 EBI-297353,EBI-712991 TOM1L1  
  .negative regulation of mitotic nuclear division
.ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.activation of protein kinase activity
  + 3 more...
.ubiquitin binding
.protein kinase activator activity
.clathrin binding
.protein kinase binding
.extracellular exosome
.endosome membrane
.cytosol
  + 4 more...
10 EBI-297353,EBI-740418 GRAP2  
  .T cell receptor signaling pathway
.innate immune response
.Fc-epsilon receptor signaling pathway
  + 4 more...
.SH3/SH2 adaptor activity .cytosol
.endosome
.cytoplasm
  + 2 more...
11 EBI-297353,EBI-286427 APBB3  
  .regulation of transcription, DNA-templated .transcription factor binding
.beta-amyloid binding
.actin cytoskeleton
.cytoplasm
.nucleus
12 EBI-297353,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
13 EBI-297353,EBI-640857 EGF  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of protein localization to cell surface
.positive regulation of hyaluronan biosynthetic process
  + 33 more...
.transmembrane receptor protein tyrosine kinase activator activity
.growth factor activity
.calcium ion binding
.epidermal growth factor receptor binding
.extracellular exosome
.platelet alpha granule lumen
.integral component of membrane
  + 4 more...
14 EBI-297353,EBI-1034374 TGFA  
  .mammary gland alveolus development
.positive regulation of epithelial cell proliferation
.positive regulation of mitotic nuclear division
  + 8 more...
.growth factor activity
.epidermal growth factor receptor binding
.perinuclear region of cytoplasm
.cytoplasmic vesicle
.basolateral plasma membrane
  + 5 more...
15 EBI-297353,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
16 EBI-297353,EBI-493507 NR3C1  
  .negative regulation of glucocorticoid mediated signaling pathway
.cellular response to steroid hormone stimulus
.mammary gland duct morphogenesis
  + 14 more...
.steroid hormone binding
.glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
.zinc ion binding
  + 5 more...
.membrane
.cytosol
.mitochondrial matrix
  + 3 more...
17 EBI-297353,EBI-354056 GAPDH  
  .cellular response to interferon-gamma
.canonical glycolysis
.neuron apoptotic process
  + 8 more...
.NAD binding
.NADP binding
.identical protein binding
  + 3 more...
.GAIT complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 11 more...
18 EBI-297353,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
19 EBI-297353,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
20 EBI-297353,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
21 EBI-297353,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
22 EBI-297353,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
23 EBI-297353,EBI-750962 ERCC1  
  .chromosome organization
.embryonic organ development
.oogenesis
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.cytoplasm
.transcription factor TFIID complex
.nucleoplasm
  + 3 more...
24 EBI-297353,EBI-629985 HSPA1A  
  .N/A .N/A .N/A
25 EBI-297353,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
26 EBI-297353,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
27 EBI-297353,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
28 EBI-297353,EBI-1383732 FGR  
  .cellular response to peptide hormone stimulus
.defense response to Gram-positive bacterium
.regulation of phagocytosis
  + 22 more...
.Fc-gamma receptor I complex binding
.immunoglobulin receptor binding
.protein kinase binding
  + 4 more...
.extracellular exosome
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
29 EBI-297353,EBI-714860 UCHL1  
  .neuromuscular process
.muscle fiber development
.negative regulation of MAP kinase activity
  + 9 more...
.ubiquitin binding
.alpha-2A adrenergic receptor binding
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.neuronal cell body
.axon
  + 4 more...
30 EBI-297353,EBI-594644 TXN  
  .negative regulation of hydrogen peroxide-induced cell death
.oxidation-reduction process
.nucleobase-containing small molecule metabolic process
  + 23 more...
.poly(A) RNA binding
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.peptide disulfide oxidoreductase activity
.protein disulfide oxidoreductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
31 EBI-297353,EBI-351896 HSPA8  
  .negative regulation of fibril organization
.regulation of cellular response to heat
.clathrin coat disassembly
  + 18 more...
.C3HC4-type RING finger domain binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.blood microparticle
.extracellular exosome
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
  + 13 more...
32 EBI-297353,EBI-727477 CDH1  
  .regulation of neuron migration
.regulation of protein localization to cell surface
.cochlea development
  + 39 more...
.cell adhesion molecule binding
.gamma-catenin binding
.GTPase activating protein binding
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 21 more...
33 EBI-297353,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
34 EBI-297353,EBI-1772443 SLC5A1  
  .transmembrane transport
.intestinal absorption
.small molecule metabolic process
  + 4 more...
.glucose:sodium symporter activity .extracellular exosome
.brush border membrane
.apical plasma membrane
  + 3 more...
35 EBI-297353,EBI-2804728 MUC1  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of histone H4 acetylation
.cellular protein metabolic process
  + 9 more...
.transcription cofactor activity
.p53 binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.vesicle
.apical plasma membrane
  + 4 more...
36 EBI-297353,EBI-2861522 PDGFRA  
  .regulation of mesenchymal stem cell differentiation
.regulation of actin cytoskeleton reorganization
.metanephric glomerular capillary formation
  + 47 more...
.platelet-derived growth factor binding
.protein homodimerization activity
.vascular endothelial growth factor binding
  + 6 more...
.protein complex
.intrinsic component of plasma membrane
.membrane
  + 6 more...
37 EBI-297353,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
38 EBI-297353,EBI-617403 PLCG2  
  .release of sequestered calcium ion into cytosol
.B cell receptor signaling pathway
.T cell receptor signaling pathway
  + 19 more...
.signal transducer activity
.phospholipase C activity
.phosphatidylinositol phospholipase C activity
.extracellular exosome
.plasma membrane
.cytosol
39 EBI-297353,EBI-1383528 PRKCA  
  .positive regulation of dense core granule biogenesis
.intrinsic apoptotic signaling pathway
.apoptotic signaling pathway
  + 56 more...
.histone kinase activity (H3-T6 specific)
.enzyme binding
.zinc ion binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 10 more...
40 EBI-297353,EBI-715709 IGFBP3  
  .negative regulation of smooth muscle cell proliferation
.positive regulation of myoblast differentiation
.type B pancreatic cell proliferation
  + 15 more...
.metal ion binding
.insulin-like growth factor II binding
.insulin-like growth factor I binding
  + 3 more...
.extracellular exosome
.insulin-like growth factor binding protein complex
.nucleus
  + 2 more...
41 EBI-297353,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
42 EBI-297353,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
43 EBI-297353,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
44 EBI-297353,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
45 EBI-297353,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
46 EBI-297353,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
47 EBI-297353,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
48 EBI-297353,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
49 EBI-297353,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
50 EBI-297353,EBI-1054052 STIP1  
  .response to stress .poly(A) RNA binding .Golgi apparatus
.nucleus
51 EBI-297353,EBI-701918 CTNNA1  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of integrin-mediated signaling pathway
  + 25 more...
.cadherin binding
.gamma-catenin binding
.poly(A) RNA binding
  + 3 more...
.lamellipodium
.catenin complex
.actin cytoskeleton
  + 7 more...
52 EBI-297353,EBI-354932 HSPA9  
  .cellular protein metabolic process
.negative regulation of apoptotic process
.protein targeting to mitochondrion
  + 2 more...
.unfolded protein binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
.ATP binding
.extracellular exosome
.mitochondrial nucleoid
.focal adhesion
  + 3 more...
53 EBI-297353,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
54 EBI-297353,EBI-1057697 STAT1  
  .negative regulation of metanephric nephron tubule epithelial cell differentiation
.metanephric mesenchymal cell differentiation
.metanephric mesenchymal cell proliferation involved in metanephros development
  + 37 more...
.protein homodimerization activity
.identical protein binding
.enzyme binding
  + 7 more...
.dendrite
.axon
.cytosol
  + 5 more...
55 EBI-297353,EBI-749537 STAT5A  
  .cellular response to granulocyte macrophage colony-stimulating factor stimulus
.positive regulation of mast cell proliferation
.mammary gland epithelium development
  + 45 more...
.signal transducer activity
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter sequence-specific DNA binding
.cytosol
.nucleoplasm
56 EBI-297353,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
57 EBI-297353,EBI-1211276 ZAP70  
  .T cell migration
.T cell aggregation
.T cell receptor signaling pathway
  + 19 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.T cell receptor complex
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
  + 4 more...
58 EBI-297353,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
59 EBI-297353,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
60 EBI-297353,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
61 EBI-297353,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
62 EBI-297353,EBI-1748958 CAMLG  
  .viral process
.epidermal growth factor receptor signaling pathway
.signal transduction
  + 2 more...
.N/A .integral component of membrane
.membrane
.endoplasmic reticulum
63 EBI-297353,EBI-2105445 BLK  
  .cellular response to peptide hormone stimulus
.B cell receptor signaling pathway
.innate immune response
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
64 EBI-297353,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
65 EBI-297353,EBI-397435 CALM2  
  .regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
66 EBI-297353,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
67 EBI-297353,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
68 EBI-297353,EBI-7256023 SHC2  
  .neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
.insulin receptor signaling pathway
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.plasma membrane
.cytosol
69 EBI-297353,EBI-6082337 ROR1  
  .peptidyl-tyrosine phosphorylation
.transmembrane receptor protein tyrosine kinase signaling pathway
.Wnt-protein binding
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.receptor complex
.integral component of plasma membrane
.plasma membrane
.cytoplasm
70 EBI-297353,EBI-2562430 AKAP12  
  .regulation of protein kinase C signaling
.positive regulation of cAMP biosynthetic process
.positive regulation of protein kinase A signaling
  + 2 more...
.protein kinase A binding
.adenylate cyclase binding
.cell cortex
.focal adhesion
.plasma membrane
  + 2 more...
71 EBI-297353,EBI-603614 CAV1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of anoikis
  + 84 more...
.inward rectifier potassium channel inhibitor activity
.nitric-oxide synthase binding
.ion channel binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 17 more...
72 EBI-297353,EBI-2266035 PTPN12  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.SH3 domain binding
.non-membrane spanning protein tyrosine phosphatase activity
.cell projection
.cell junction
.plasma membrane
  + 3 more...
73 EBI-297353,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
74 EBI-297353,EBI-2555881 AHNAK  
  .regulation of voltage-gated calcium channel activity
.protein oligomerization
.regulation of RNA splicing
.structural molecule activity conferring elasticity
.poly(A) RNA binding
.S100 protein binding
.extracellular exosome
.cell-cell contact zone
.costamere
  + 11 more...
75 EBI-297353,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
76 EBI-297353,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
77 EBI-297353,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
78 EBI-297353,EBI-726214 SLA  
  .positive regulation of signal transduction .SH3/SH2 adaptor activity .endosome
79 EBI-297353,EBI-722813 MAPK8IP2  
  .regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
.regulation of N-methyl-D-aspartate selective glutamate receptor activity
.regulation of excitatory postsynaptic membrane potential
  + 13 more...
.protein kinase activator activity
.protein kinase binding
.kinesin binding
  + 3 more...
.neuronal postsynaptic density
.protein complex
.neuronal cell body
.cytoplasm
80 EBI-297353,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
81 EBI-297353,EBI-366017 RIN1  
  .negative regulation of synaptic plasticity
.associative learning
.memory
  + 2 more...
.GTPase activator activity .neuronal cell body
.dendrite
.plasma membrane
  + 2 more...
82 EBI-297353,EBI-351886 CTTN  
  .negative regulation of extrinsic apoptotic signaling pathway
.lamellipodium organization
.dendritic spine maintenance
  + 12 more...
.profilin binding .mitotic spindle midzone
.extracellular exosome
.dendritic spine
  + 10 more...
83 EBI-297353,EBI-724839 FKBP8  
  .chaperone-mediated protein folding
.negative regulation of apoptotic process
.camera-type eye development
  + 10 more...
.metal ion binding
.identical protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.mitochondrial membrane
.integral component of endoplasmic reticulum membrane
.membrane
.endoplasmic reticulum membrane
84 EBI-297353,EBI-949378 BECN1  
  .positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
85 EBI-297353,EBI-80371 ERBB4  
  .positive regulation of STAT protein import into nucleus
.positive regulation of ERK1 and ERK2 cascade
.cardiac muscle tissue regeneration
  + 33 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.ATP binding
  + 4 more...
.receptor complex
.basolateral plasma membrane
.integral component of membrane
  + 7 more...
86 EBI-297353,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
87 EBI-297353,EBI-1050422 LRRK1  
  .positive regulation of intracellular signal transduction
.negative regulation of peptidyl-tyrosine phosphorylation
.positive regulation of peptidyl-tyrosine phosphorylation
  + 3 more...
.metal ion binding
.identical protein binding
.GTP binding
  + 2 more...
.mitochondrion
.cytoplasm
88 EBI-297353,EBI-1220488 TNS3  
  .lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
89 EBI-297353,EBI-2880244 DOK6  
  .N/A .N/A .N/A
90 EBI-297353,EBI-9453524 SHC4  
  .stem cell differentiation
.intracellular signal transduction
.regulation of gene expression
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.postsynaptic membrane
.cell junction
.plasma membrane
91 EBI-297353,EBI-3940924 RAPH1  
  .axon extension
.signal transduction
.cell-matrix adhesion
.N/A .filopodium
.lamellipodium
.plasma membrane
  + 2 more...
92 EBI-297353,EBI-302552 TUBA1A  
  .cell division
.protein polymerization
.'de novo' posttranslational protein folding
  + 7 more...
.GTP binding
.structural constituent of cytoskeleton
.structural molecule activity
.GTPase activity
.extracellular exosome
.recycling endosome
.cytoplasmic ribonucleoprotein granule
  + 4 more...
93 EBI-297353,EBI-7878194 CLNK  
  .intracellular signal transduction
.positive regulation of signal transduction
.transmembrane receptor protein tyrosine kinase signaling pathway
.immune response
.SH3/SH2 adaptor activity .intracellular
94 EBI-297353,EBI-1048378 HDAC7  
  .positive regulation of cell migration involved in sprouting angiogenesis
.negative regulation of osteoblast differentiation
.cellular protein metabolic process
  + 8 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.14-3-3 protein binding
.repressing transcription factor binding
  + 9 more...
.cytoplasm
.nucleoplasm
.nucleus
.histone deacetylase complex
95 EBI-297353,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
96 EBI-297353,EBI-1048612 ANKS1A  
  .ephrin receptor signaling pathway
.neuron remodeling
.substrate-dependent cell migration
.N/A .neuron projection
.cytoplasm
.nucleoplasm
97 EBI-297353,EBI-79277 APBB2  
  .negative regulation of apoptotic process
.positive regulation of apoptotic process
.intracellular signal transduction
  + 6 more...
.transcription factor binding
.beta-amyloid binding
.synapse
.growth cone
.lamellipodium
  + 3 more...
98 EBI-297353,EBI-297683 AP2M1  
  .negative regulation of protein localization to plasma membrane
.clathrin-mediated endocytosis
.membrane organization
  + 10 more...
.low-density lipoprotein particle receptor binding
.lipid binding
.transporter activity
.signal sequence binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.endocytic vesicle membrane
  + 5 more...
99 EBI-297353,EBI-448974 CYTH2  
  .positive regulation of GTPase activity
.regulation of cell adhesion
.actin cytoskeleton organization
.endocytosis
.inositol 1,4,5 trisphosphate binding
.lipid binding
.ARF guanyl-nucleotide exchange factor activity
.membrane
.plasma membrane
.cytoplasm
100 EBI-297353,EBI-2339271 SH2D3A  
  .positive regulation of signal transduction
.small GTPase mediated signal transduction
.JNK cascade
.guanyl-nucleotide exchange factor activity
.SH3/SH2 adaptor activity
.N/A
101 EBI-297353,EBI-310491 SH2B1  
  .regulation of DNA biosynthetic process
.positive regulation of mitotic nuclear division
.intracellular signal transduction
  + 2 more...
.signaling adaptor activity
.signal transducer activity
.membrane
.cytosol
.nucleus
102 EBI-297353,EBI-617866 CISH  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.negative regulation of insulin receptor signaling pathway
.negative regulation of JAK-STAT cascade
  + 6 more...
.protein kinase inhibitor activity .plasma membrane
.cytosol
.cytoplasm
103 EBI-297353,EBI-1059156 VAPA  
  .COPII-coated vesicle budding
.protein localization to endoplasmic reticulum
.membrane fusion
  + 11 more...
.protein heterodimerization activity
.FFAT motif binding
.protein domain specific binding
  + 2 more...
.vesicle
.integral component of membrane
.microtubule cytoskeleton
  + 4 more...
104 EBI-297353,EBI-301697 HDAC6  
  .positive regulation of hydrogen peroxide-mediated programmed cell death
.tubulin deacetylation
.positive regulation of chaperone-mediated protein complex assembly
  + 38 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.dynein complex binding
.Hsp90 protein binding
  + 16 more...
.perinuclear region of cytoplasm
.perikaryon
.cell leading edge
  + 13 more...
105 EBI-297353,EBI-913954 RABGEF1  
  .negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
106 EBI-297353,EBI-2941912 ERRFI1  
  .lung epithelium development
.lung vasculature development
.lung alveolus development
  + 6 more...
.protein kinase binding
.GTPase activator activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
107 EBI-297353,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
108 EBI-297353,EBI-357085 STUB1  
  .positive regulation of chaperone-mediated protein complex assembly
.cellular response to misfolded protein
.protein K63-linked ubiquitination
  + 16 more...
.ubiquitin protein ligase activity
.Hsp90 protein binding
.misfolded protein binding
  + 12 more...
.extracellular exosome
.intermediate filament cytoskeleton
.nuclear inclusion body
  + 7 more...
109 EBI-297353,EBI-78404 MAPK8IP1  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of JNK cascade
.negative regulation of JUN kinase activity
  + 3 more...
.kinesin binding
.MAP-kinase scaffold activity
.protein kinase inhibitor activity
.perinuclear region of cytoplasm
.synapse
.dentate gyrus mossy fiber
  + 8 more...
110 EBI-297353,EBI-7879749 SH2B3  
  .intracellular signal transduction
.embryonic hemopoiesis
.cell differentiation
.blood coagulation
.phosphate ion binding
.signaling adaptor activity
.signal transducer activity
.cytosol
111 EBI-297353,EBI-3385920 MAST1  
  .intracellular signal transduction
.cytoskeleton organization
.protein phosphorylation
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.plasma membrane
.cytoskeleton
.cytoplasm
112 EBI-297353,EBI-1211241 PTPN22  
  .negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
113 EBI-297353,EBI-2462036 TLN1  
  .platelet aggregation
.cellular protein metabolic process
.IRE1-mediated unfolded protein response
  + 12 more...
.LIM domain binding
.vinculin binding
.structural constituent of cytoskeleton
.integrin binding
.extracellular exosome
.ruffle membrane
.cell surface
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites50
bladder133
bone27
brain29
cervix61
connective tissue20
embryonic tissue14
esophagus49
eye76
heart33
intestine30
kidney42
larynx127
liver9
lung50
mammary gland66
mouth347
muscle56
nerve64
ovary98
pharynx24
placenta332
prostate47
skin33
stomach52
testis11
thymus25
thyroid85
uterus21
vascular38
Health State
TissuesTPM*
normal57
bladder carcinoma170
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma72
colorectal tumor35
esophageal tumor57
gastrointestinal tumor42
germ cell tumor7
glioma102
head and neck tumor231
kidney tumor29
lung tumor48
non-neoplasia31
ovarian tumor144
primitive neuroectodermal tumor of the CNS31
prostate cancer28
uterine tumor44
Developmental Stage
TissuesTPM*
adult64
embryoid body14
blastocyst16
fetus86
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.9
adrenal gland10.8
appendix4.4
cerebral cortex12.3
colon14.3
duodenum5.3
esophagus23.9
gallbladder10.2
heart muscle3.9
kidney11.4
liver21.3
lung15.4
lymph node2.5
ovary15.1
pancreas8.2
placenta91.3
prostate14.8
salivary gland16.4
skin43.2
small intestine6.7
spleen5.4
stomach9
testis5.4
thyroid gland22.9
urinary bladder11.5
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastLow
bronchusHigh
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumLow
epididymisMedium
esophagusMedium
gallbladderHigh
kidneyLow
liverMedium
nasopharynxHigh
oral mucosaHigh
placentaHigh
prostateMedium
rectumMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineLow
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderLow
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*131550, gene) Epidermal growth factor receptor; EGFROMIM
2(#211980, phenotype) Lung cancerOMIM
3glioma;non small cell lung cancer;Familial lung cancerCGP


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