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> Protein (NX_P01100)
Protein (NX_P01100)
Protein
Gene SymbolFOS to neXtProt (NX_P01100)
DescriptionProto-oncogene c-Fos
Chromosome14
Location14q24.3 (75745477 ~ 75748933) to Ensembl
Sequene Features : Isoforms 3, Variants 38, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to calcium ion
.SMAD protein signal transduction
.response to cAMP
  + 44 more...
.R-SMAD binding
.transcription regulatory region DNA binding
.transcription factor binding
  + 3 more...
.neuron projection
.membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 38 10
2014-09-19protein level
3 29 10
2014-05-27protein level
1 29 10
2014-02-25protein level
1 29 10
2013-12-09protein level
1 24 10
2013-11-01protein level
1 22 10
2013-09-12protein level
1 22 10
2013-08-17protein level
1 22 10
2013-07-15protein level
1 15 10
2013-06-11protein level
1 15 10
2013-02-12protein level
1 8 7
2012-12-20protein level
1 8 7
2012-10-30protein level
1 8 7
2012-10-07protein level
1 8 7
2012-08-24protein level
1 6 7
2012-07-28protein level
1 6 7
2012-06-08protein level
1 17 7
2012-05-07protein level
1 15 7
2012-04-10protein level
1 15 7
2012-01-13protein level
1 14 7
2011-12-20protein level
1 14 7
2011-11-11protein level
1 14 7
2011-08-23protein level
1 14 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P01100-1
0 12 0 40669.5864
NX_P01100-2
0 9 0 28968.1219
NX_P01100-3
1 10 0 36278.2638
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-852851,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
2 EBI-852851,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
3 EBI-852851,EBI-1104674 CLU  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of neurofibrillary tangle assembly
  + 34 more...
.misfolded protein binding
.chaperone binding
.ubiquitin protein ligase binding
.apical dendrite
.neurofibrillary tangle
.blood microparticle
  + 15 more...
4 EBI-852851,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
5 EBI-852851,EBI-748062 JUNB  
  .cellular response to calcium ion
.labyrinthine layer blood vessel development
.embryonic process involved in female pregnancy
  + 28 more...
.transcription factor binding
.transcription corepressor activity
.transcription coactivator activity
  + 4 more...
.transcription factor complex
.nucleoplasm
.nuclear chromatin
.chromatin
6 EBI-852851,EBI-2682803 JUND  
  .cellular response to calcium ion
.regulation of cell cycle
.response to cAMP
  + 18 more...
.transcription regulatory region DNA binding
.enzyme binding
.transcription factor binding
  + 4 more...
.transcription factor complex
.nucleoplasm
.nucleus
  + 2 more...
7 EBI-852851,EBI-1057697 STAT1  
  .negative regulation of metanephric nephron tubule epithelial cell differentiation
.metanephric mesenchymal cell differentiation
.metanephric mesenchymal cell proliferation involved in metanephros development
  + 37 more...
.protein homodimerization activity
.identical protein binding
.enzyme binding
  + 7 more...
.dendrite
.axon
.cytosol
  + 5 more...
8 EBI-852851,EBI-2687350 ZNF133  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
9 EBI-852851,EBI-742413 COPS4  
  .cullin deneddylation
.protein deneddylation
.N/A .extracellular exosome
.cell junction
.COP9 signalosome
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue2409
adrenal gland1882
ascites125
bladder535
blood5734
bone237
bone marrow205
brain529
cervix1175
connective tissue603
ear931
embryonic tissue46
esophagus1687
eye215
heart603
intestine594
kidney279
larynx213
liver165
lung206
lymph node22
mammary gland343
mouth846
muscle291
nerve450
ovary344
pancreas431
parathyroid97
pharynx73
pituitary gland363
placenta127
prostate316
skin75
spleen730
stomach344
testis66
thymus439
thyroid1373
trachea4345
umbilical cord799
uterus1021
vascular1258
Health State
TissuesTPM*
adrenal tumor158
bladder carcinoma227
breast (mammary gland) tumor236
cervical tumor695
chondrosarcoma325
colorectal tumor186
esophageal tumor1971
gastrointestinal tumor202
germ cell tumor34
glioma55
head and neck tumor336
kidney tumor319
leukemia84
liver tumor208
lung tumor77
lymphoma13
non-neoplasia672
ovarian tumor354
pancreatic tumor161
primitive neuroectodermal tumor of the CNS47
prostate cancer173
skin tumor39
soft tissue/muscle tissue tumor63
uterine tumor366
Developmental Stage
TissuesTPM*
adult287
embryoid body28
blastocyst81
neonate547
fetus114
infant127
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue734.5
adrenal gland618.9
appendix474.8
bone marrow1015.8
cerebral cortex116.7
colon263.3
duodenum191.2
esophagus935.5
gallbladder996
heart muscle147.3
kidney288.4
liver230.2
lung450.5
lymph node380.4
ovary873.5
pancreas73.7
placenta283.7
prostate803.2
salivary gland391.9
skin35.7
small intestine465.7
spleen153
stomach347.8
testis122.7
thyroid gland675.7
urinary bladder521
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164810, gene) V-fos fbj murine osteosarcoma viral oncogene homolog; FOSOMIM


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