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> Protein (NX_P01106)
Protein (NX_P01106)
Protein
Gene SymbolMYC to neXtProt (NX_P01106)
DescriptionMyc proto-oncogene protein
Chromosome8
Location8q24.21 (128747680 ~ 128753674) to Ensembl
Sequene Features : Isoforms 2, Variants 85, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 85 20
2014-09-19protein level
2 72 20
2014-05-27protein level
2 72 20
2014-02-25protein level
2 72 20
2013-12-09protein level
2 69 20
2013-11-01protein level
2 69 20
2013-09-12protein level
2 69 20
2013-08-17protein level
2 69 20
2013-07-15protein level
2 47 19
2013-06-11protein level
2 47 19
2013-02-12protein level
2 18 38
2012-12-20protein level
2 18 38
2012-10-30protein level
2 19 38
2012-10-07protein level
2 19 19
2012-08-24protein level
2 18 19
2012-07-28protein level
2 18 19
2012-06-08protein level
2 25 19
2012-05-07protein level
2 25 19
2012-04-10protein level
2 25 19
2012-01-13protein level
2 25 19
2011-12-20protein level
2 25 19
2011-11-11protein level
2 25 19
2011-08-23protein level
2 25 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P01106-1
1 14 1 48773.8152
NX_P01106-2
1 14 1 50533.6456
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-447544,EBI-7689134 BIN1  
  .regulation of cell cycle arrest
.lipid tube assembly
.positive regulation of astrocyte differentiation
  + 8 more...
.RNA polymerase binding
.tau protein binding
.identical protein binding
.lipid tube
.cerebellar mossy fiber
.axon terminus
  + 12 more...
2 EBI-447544,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-447544,EBI-710484 AXIN1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
4 EBI-447544,EBI-607682 HDAC3  
  .cellular response to fluid shear stress
.spindle assembly
.neurotrophin TRK receptor signaling pathway
  + 21 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.transcriptional repressor complex
.plasma membrane
.spindle microtubule
  + 5 more...
5 EBI-447544,EBI-540462 SIN3B  
  .cardiac muscle tissue development
.small molecule metabolic process
.cellular lipid metabolic process
  + 3 more...
.chromatin binding
.RNA polymerase II transcription corepressor activity
.autosome
.Sin3 complex
.cytoplasm
  + 5 more...
6 EBI-447544,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
7 EBI-447544,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
8 EBI-447544,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
9 EBI-447544,EBI-876302 TOP1  
  .response to drug
.embryonic cleavage
.circadian regulation of gene expression
  + 8 more...
.poly(A) RNA binding
.DNA topoisomerase type II (ATP-hydrolyzing) activity
.DNA topoisomerase type I activity
  + 3 more...
.perikaryon
.replication fork protection complex
.nucleolus
  + 3 more...
10 EBI-447544,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
11 EBI-447544,EBI-396235 UBTF  
  .positive regulation of transcription from RNA polymerase I promoter
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 8 more...
.poly(A) RNA binding
.chromatin binding
.DNA binding
.nucleolus
.nucleoplasm
12 EBI-447544,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
13 EBI-447544,EBI-751711 MAX  
  .cellular response to peptide hormone stimulus
.retina development in camera-type eye
.neuron apoptotic process
  + 6 more...
.sequence-specific DNA binding
.transcription coactivator activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
.MLL1 complex
.dendrite
.PML body
  + 3 more...
14 EBI-447544,EBI-354380 RPL11  
  .cellular protein metabolic process
.ribosomal large subunit biogenesis
.protein localization to nucleus
  + 12 more...
.poly(A) RNA binding
.rRNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
15 EBI-447544,EBI-372156 ZBTB17  
  .positive regulation of transcription, DNA-templated
.negative regulation of cell cycle
.cellular protein metabolic process
  + 5 more...
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleoplasm
16 EBI-447544,EBI-456291 SKP2  
  .cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
17 EBI-447544,EBI-372916 CHD4  
  .spindle assembly
.ATP-dependent chromatin remodeling
.DNA duplex unwinding
  + 3 more...
.zinc ion binding
.ATP binding
.ATP-dependent DNA helicase activity
  + 2 more...
.protein complex
.NuRD complex
.membrane
  + 5 more...
18 EBI-447544,EBI-357897 EFTUD2  
  .gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.GTP binding
.GTPase activity
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 4 more...
19 EBI-447544,EBI-1383460 BRD3  
  .chromatin modification
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.lysine-acetylated histone binding
.chromatin binding
.nucleus
20 EBI-447544,EBI-308614 CEP57  
  .protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
21 EBI-447544,EBI-355410 CCAR2  
  .positive regulation of DNA damage checkpoint
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.regulation of cellular response to heat
  + 14 more...
.poly(A) RNA binding
.enzyme binding
.enzyme inhibitor activity
.RNA polymerase II core binding
.DBIRD complex
.mitochondrial matrix
.cytoplasm
  + 3 more...
22 EBI-447544,EBI-914770 FBXW8  
  .labyrinthine layer blood vessel development
.spongiotrophoblast layer development
.positive regulation of dendrite morphogenesis
  + 3 more...
.N/A .perinuclear region of cytoplasm
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
23 EBI-447544,EBI-712415 SIRT6  
  .histone H3-K9 deacetylation
.histone H3-K9 modification
.histone deacetylation
  + 2 more...
.NAD+ binding
.NAD-dependent histone deacetylase activity (H3-K9 specific)
.NAD-dependent histone deacetylase activity
  + 4 more...
.intracellular membrane-bounded organelle
.nucleolus
.nuclear telomeric heterochromatin
  + 2 more...
24 EBI-447544,EBI-749336 SNIP1  
  .positive regulation of protein targeting to mitochondrion
.production of miRNAs involved in gene silencing by miRNA
.I-kappaB kinase/NF-kappaB signaling
.regulation of transcription, DNA-templated
.poly(A) RNA binding .cytoplasm
.nucleoplasm
25 EBI-447544,EBI-1379376 KIAA1524  
  .positive regulation of neural precursor cell proliferation
.spermatogenesis
.N/A .integral component of membrane
.plasma membrane
.cytoplasm
26 EBI-447544,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
27 EBI-447544,EBI-359574 FBXW7  
  .negative regulation of SREBP signaling pathway
.negative regulation of hepatocyte proliferation
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 24 more...
.ubiquitin-protein transferase activator activity
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.Parkin-FBXW7-Cul1 ubiquitin ligase complex
.protein complex
.SCF ubiquitin ligase complex
  + 5 more...
28 EBI-447544,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
29 EBI-447544,EBI-399128 TRRAP  
  .histone H2A acetylation
.histone H4 acetylation
.histone deubiquitination
  + 7 more...
.phosphotransferase activity, alcohol group as acceptor
.kinase activity
.transcription coactivator activity
.transcription cofactor activity
.NuA4 histone acetyltransferase complex
.transcription factor TFTC complex
.STAGA complex
  + 5 more...
30 EBI-447544,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites125
bladder200
blood188
bone55
bone marrow615
brain45
cervix164
connective tissue87
ear124
embryonic tissue14
esophagus148
eye14
heart33
intestine137
kidney52
liver63
lung38
lymph158
lymph node33
mammary gland72
mouth181
muscle37
ovary59
pancreas46
placenta42
prostate89
salivary gland49
skin61
spleen37
stomach156
testis11
thymus100
thyroid21
trachea115
uterus90
vascular174
Health State
TissuesTPM*
normal54
adrenal tumor79
breast (mammary gland) tumor42
cervical tumor202
chondrosarcoma84
colorectal tumor106
esophageal tumor173
gastrointestinal tumor135
germ cell tumor72
glioma55
head and neck tumor82
kidney tumor58
leukemia264
liver tumor83
lung tumor68
lymphoma277
non-neoplasia51
ovarian tumor65
pancreatic tumor19
primitive neuroectodermal tumor of the CNS94
prostate cancer105
skin tumor39
soft tissue/muscle tissue tumor55
uterine tumor66
Developmental Stage
TissuesTPM*
adult68
embryoid body28
neonate128
fetus44
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue91.7
adrenal gland48.4
appendix51.4
bone marrow29.6
cerebral cortex11.4
colon37.1
duodenum24
esophagus77
gallbladder78.2
heart muscle7.3
kidney6.7
liver46.3
lung20.4
lymph node40
ovary53.5
pancreas44.6
placenta22.8
prostate29.5
salivary gland18.5
skin25.6
small intestine26.1
spleen45.1
stomach24.4
testis12.3
thyroid gland8.9
urinary bladder38.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#113970, phenotype) Burkitt lymphoma; BLOMIM
2(*190080, gene) V-myc avian myelocytomatosis viral oncogene homolog; MYCOMIM
3Burkitt lymphoma;amplified in other cancers;B-cell Lymphocytic leukemiaCGP


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