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> Protein (NX_P01135)
Protein (NX_P01135)
Protein
Gene SymbolTGFA to neXtProt (NX_P01135)
DescriptionProtransforming growth factor alpha
Chromosome2
Location2p13.3 (70674412 ~ 70781325) to Ensembl
Sequene Features : Isoforms 5, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mammary gland alveolus development
.positive regulation of epithelial cell proliferation
.positive regulation of mitotic nuclear division
  + 8 more...
.growth factor activity
.epidermal growth factor receptor binding
.perinuclear region of cytoplasm
.cytoplasmic vesicle
.basolateral plasma membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 27 6
2014-09-19protein level
5 18 6
2014-05-27protein level
5 18 6
2014-02-25protein level
5 18 6
2013-12-09protein level
5 13 6
2013-11-01protein level
5 10 6
2013-09-12protein level
5 10 6
2013-08-17protein level
5 10 6
2013-07-15protein level
5 8 6
2013-06-11protein level
5 8 6
2013-02-12protein level
5 5 30
2012-12-20protein level
5 5 30
2012-10-30protein level
5 6 30
2012-10-07protein level
5 6 6
2012-08-24protein level
5 5 6
2012-07-28protein level
5 5 6
2012-06-08protein level
5 4 6
2012-05-07protein level
5 4 6
2012-04-10protein level
5 4 6
2012-01-13protein level
5 4 6
2011-12-20protein level
5 4 6
2011-11-11protein level
5 4 6
2011-08-23protein level
5 4 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P01135-1
0 6 0 16994.4891
NX_P01135-2
0 6 0 16923.4522
NX_P01135-3
1 5 0 17067.5053
NX_P01135-4
0 6 0 17388.6304
NX_P01135-5
0 6 0 17317.5935
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1034374,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-1034374,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone marrow20
brain39
cervix20
embryonic tissue9
eye19
intestine12
kidney47
lung11
mammary gland19
mouth75
muscle18
nerve64
pancreas28
skin42
spleen18
stomach20
testis4
thyroid150
trachea115
uterus8
Health State
TissuesTPM*
normal19
cervical tumor28
colorectal tumor17
gastrointestinal tumor16
glioma18
head and neck tumor89
kidney tumor43
leukemia21
lung tumor9
skin tumor39
soft tissue/muscle tissue tumor87
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
embryoid body28
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.9
appendix4.7
bone marrow1.1
cerebral cortex6.6
colon10
duodenum7.1
esophagus25.5
gallbladder14.8
kidney11.8
liver2.5
lung3.2
lymph node3.6
pancreas3.6
placenta1.1
prostate2.3
salivary gland2.2
skin8.6
small intestine8.8
spleen4.3
stomach6.7
testis1.5
thyroid gland8.7
urinary bladder6.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*190170, gene) Transforming growth factor, alpha; TGFAOMIM


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