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> Protein (NX_P02008)
Protein (NX_P02008)
Protein
Gene SymbolHBZ to neXtProt (NX_P02008)
DescriptionHemoglobin subunit zeta
Chromosome16
Location16p13.3 (202686 ~ 204502) to Ensembl
Sequene Features : Isoforms 1, Variants 4, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.erythrocyte maturation
.negative regulation of transcription from RNA polymerase II promoter
.heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.extracellular exosome
.hemoglobin complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 4 1
2014-09-19protein level
1 2 1
2014-05-27protein level
1 2 1
2014-02-25protein level
1 2 1
2013-12-09protein level
1 3 1
2013-11-01protein level
1 3 1
2013-09-12protein level
1 3 1
2013-08-17protein level
1 3 1
2013-07-15protein level
1 2 1
2013-06-11protein level
1 2 1
2013-02-12protein level
1 2 1
2012-12-20protein level
1 2 1
2012-10-30protein level
1 2 1
2012-10-07protein level
1 2 1
2012-08-24protein level
1 2 1
2012-07-28protein level
1 2 1
2012-06-08protein level
1 2 1
2012-05-07protein level
1 2 1
2012-04-10protein level
1 2 1
2012-01-13protein level
1 0 1
2011-12-20protein level
1 0 1
2011-11-11protein level
1 0 1
2011-08-23protein level
1 0 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02008-1
10 0 0 15627.1918
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-719843,EBI-6152722 HBD  
  .blood coagulation .heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.blood microparticle
.hemoglobin complex
.cytosol
2 EBI-719843,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
3 EBI-719843,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
4 EBI-719843,EBI-715554 HBB  
  .platelet aggregation
.renal absorption
.oxidation-reduction process
  + 13 more...
.hemoglobin binding
.heme binding
.oxygen binding
  + 2 more...
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 4 more...
5 EBI-719843,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
6 EBI-719843,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-719843,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
8 EBI-719843,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
heart11
placenta7
spleen18
testis4
thymus12
Health State
TissuesTPM*
normal12
leukemia21
Developmental Stage
TissuesTPM*
adult3
fetus62
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
bone marrow1.3
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*142310, gene) Hemoglobin--zeta locus; HBZOMIM


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