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> Protein (NX_P02489)
Protein (NX_P02489)
Protein
Gene SymbolCRYAA to neXtProt (NX_P02489)
DescriptionAlpha-crystallin A chain
Chromosome21
Location21q22.3 (44589118 ~ 44592915) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homooligomerization
.response to stimulus
.negative regulation of apoptotic process
  + 2 more...
.unfolded protein binding
.metal ion binding
.identical protein binding
.structural constituent of eye lens
.extracellular exosome
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 13
2014-09-19protein level
1 28 13
2014-05-27protein level
1 28 13
2014-02-25protein level
1 28 13
2013-12-09protein level
1 23 13
2013-11-01protein level
1 21 13
2013-09-12protein level
1 20 13
2013-08-17protein level
1 20 7
2013-07-15protein level
1 13 7
2013-06-11protein level
1 13 7
2013-02-12protein level
1 9 15
2012-12-20protein level
1 9 15
2012-10-30protein level
1 9 15
2012-10-07protein level
1 9 15
2012-08-24protein level
1 7 15
2012-07-28protein level
1 7 15
2012-06-08protein level
1 9 14
2012-05-07protein level
1 8 14
2012-04-10protein level
1 8 14
2012-01-13protein level
1 10 14
2011-12-20protein level
1 10 14
2011-11-11protein level
1 10 14
2011-08-23protein level
1 10 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02489-1
11 0 0 19896.8403
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6875961,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-6875961,EBI-739060 CRYAB  
  .negative regulation of reactive oxygen species metabolic process
.cellular response to gamma radiation
.apoptotic process involved in morphogenesis
  + 18 more...
.unfolded protein binding
.metal ion binding
.protein homodimerization activity
  + 2 more...
.extracellular exosome
.actin filament bundle
.Z disc
  + 8 more...
3 EBI-6875961,EBI-6875941 CRYGC  
  .camera-type eye development
.visual perception
.structural constituent of eye lens .cytoplasm
.nucleus
4 EBI-6875961,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
5 EBI-6875961,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
6 EBI-6875961,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
cervix20
eye1532
kidney109
liver4
placenta3
thymus12
Health State
TissuesTPM*
normal108
cervical tumor28
Developmental Stage
TissuesTPM*
adult149
fetus86
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
kidney115.1
liver16.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(+123580, gene/phenotype) Crystallin, alpha-a; CRYAAOMIM
2(#604219, phenotype) Cataract, autosomal dominantOMIM


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