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> Protein (NX_P02538)
Protein (NX_P02538)
Protein
Gene SymbolKRT6A to neXtProt (NX_P02538)
DescriptionKeratin, type II cytoskeletal 6A
Chromosome12
Location12q13.13 (52880958 ~ 52887041) to Ensembl
Sequene Features : Isoforms 1, Variants 134, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 134 1
2014-09-19protein level
1 97 1
2014-05-27protein level
1 97 8
2014-02-25protein level
1 97 7
2013-12-09protein level
1 73 7
2013-11-01protein level
1 72 5
2013-09-12protein level
1 72 5
2013-08-17protein level
1 72 5
2013-07-15protein level
1 53 5
2013-06-11protein level
1 53 5
2013-02-12protein level
1 38 7
2012-12-20protein level
1 33 7
2012-10-30protein level
1 36 7
2012-10-07protein level
1 36 7
2012-08-24protein level
1 28 7
2012-07-28protein level
1 28 7
2012-06-08protein level
1 35 7
2012-05-07protein level
1 35 7
2012-04-10protein level
1 35 7
2012-01-13protein level
1 36 7
2011-12-20protein level
1 36 7
2011-11-11protein level
1 36 6
2011-08-23protein level
1 38 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02538-1
3 0 25 60008.1011
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-702198,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-702198,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
3 EBI-702198,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
4 EBI-702198,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
5 EBI-702198,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
6 EBI-702198,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
7 EBI-702198,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-702198,EBI-739674 CCDC85B  
  .negative regulation of transcription, DNA-templated
.negative regulation of fat cell differentiation
.negative regulation of cell growth
  + 2 more...
.N/A .centrosome
.cytoplasm
.nucleus
9 EBI-702198,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-702198,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
11 EBI-702198,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
12 EBI-702198,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder870
brain93
cervix41
esophagus1091
eye33
heart33
intestine34
kidney4
larynx7414
lung65
lymph node11
mammary gland59
mouth1647
muscle37
ovary137
pancreas135
pharynx8545
placenta151
prostate712
skin692
stomach31
testis4
thymus12
thyroid536
uterus271
vascular19
Health State
TissuesTPM*
normal83
bladder carcinoma1478
cervical tumor28
colorectal tumor71
esophageal tumor1101
gastrointestinal tumor25
glioma848
head and neck tumor4625
kidney tumor14
lung tumor87
non-neoplasia41
ovarian tumor183
pancreatic tumor276
primitive neuroectodermal tumor of the CNS7
prostate cancer77
skin tumor917
uterine tumor344
Developmental Stage
TissuesTPM*
adult477
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix2
esophagus2103.7
liver2.5
placenta6.3
prostate1
salivary gland1.1
skin27.3
urinary bladder2.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*148041, gene) Keratin 6a; KRT6AOMIM


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