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> Protein (NX_P02647)
Protein (NX_P02647)
Protein
Gene SymbolAPOA1 to neXtProt (NX_P02647)
DescriptionApolipoprotein A-I
Chromosome11
Location11q23.3 (116706467 ~ 116708666) to Ensembl
Sequene Features : Isoforms 1, Variants 63, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of substrate adhesion-dependent cell spreading
.cholesterol import
.triglyceride homeostasis
  + 61 more...
.high-density lipoprotein particle receptor binding
.phosphatidylcholine-sterol O-acyltransferase activator activity
.lipase inhibitor activity
  + 12 more...
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 17 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 63 5
2014-09-19protein level
1 51 5
2014-05-27protein level
1 51 5
2014-02-25protein level
1 50 5
2013-12-09protein level
1 42 5
2013-11-01protein level
1 42 5
2013-09-12protein level
1 42 5
2013-08-17protein level
1 42 5
2013-07-15protein level
1 38 3
2013-06-11protein level
1 38 3
2013-02-12protein level
1 32 4
2012-12-20protein level
1 33 4
2012-10-30protein level
1 33 4
2012-10-07protein level
1 33 4
2012-08-24protein level
1 30 4
2012-07-28protein level
1 30 4
2012-06-08protein level
1 31 4
2012-05-07protein level
1 31 4
2012-04-10protein level
1 31 4
2012-01-13protein level
1 30 2
2011-12-20protein level
1 30 2
2011-11-11protein level
1 30 2
2011-08-23protein level
1 30 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02647-1
15 0 0 30758.8439
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-701692,EBI-784112 ABCA1  
  .anion transmembrane transport
.cellular response to cholesterol
.cellular response to retinoic acid
  + 32 more...
.ATPase binding
.ATPase activity, coupled to transmembrane movement of substances
.apolipoprotein A-I receptor activity
  + 11 more...
.perinuclear region of cytoplasm
.phagocytic vesicle
.membrane raft
  + 6 more...
2 EBI-701692,EBI-1220767 HP  
  .negative regulation of hydrogen peroxide catabolic process
.negative regulation of oxidoreductase activity
.defense response to bacterium
  + 6 more...
.hemoglobin binding
.antioxidant activity
.catalytic activity
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 3 more...
3 EBI-701692,EBI-348571 FGA  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of blood coagulation, common pathway
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 20 more...
.structural molecule activity .blood microparticle
.extracellular exosome
.vesicle
  + 9 more...
4 EBI-701692,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
5 EBI-701692,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
brain11
embryonic tissue23
heart100
intestine12
liver2177
lung74
muscle9
ovary78
pancreas18
placenta24
spleen805
testis103
thymus12
Health State
TissuesTPM*
normal172
colorectal tumor17
germ cell tumor45
leukemia42
liver tumor906
ovarian tumor65
Developmental Stage
TissuesTPM*
adult183
embryoid body28
blastocyst16
fetus333
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix2.5
duodenum917.2
gallbladder1.7
heart muscle24.7
liver3839.1
lung1.9
lymph node1.4
ovary16
placenta1.4
small intestine1681.4
spleen1.9
stomach9.9
testis201
thyroid gland1.4
Tissues
TissuesExpression level
kidneyMedium
liverLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#105200, phenotype) Amyloidosis, familial visceralOMIM
2(+107680, gene/phenotype) Apolipoprotein a-i; APOA1OMIM
3(#205400, phenotype) Tangier disease; TGDOMIM
4(#604091, phenotype) Hypoalphalipoproteinemia, primaryOMIM


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