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> Protein (NX_P02671)
Protein (NX_P02671)
Protein
Gene SymbolFGA to neXtProt (NX_P02671)
DescriptionFibrinogen alpha chain
Chromosome4
Location4q31.3 (155504278 ~ 155511918) to Ensembl
Sequene Features : Isoforms 2, Variants 220, PTMs 31 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endothelial cell apoptotic process
.negative regulation of blood coagulation, common pathway
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 20 more...
.structural molecule activity .blood microparticle
.extracellular exosome
.vesicle
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 220 31
2014-09-19protein level
2 159 31
2014-05-27protein level
2 159 31
2014-02-25protein level
2 155 31
2013-12-09protein level
2 135 30
2013-11-01protein level
2 129 30
2013-09-12protein level
2 129 30
2013-08-17protein level
2 129 30
2013-07-15protein level
2 85 23
2013-06-11protein level
2 85 23
2013-02-12protein level
2 43 49
2012-12-20protein level
2 43 49
2012-10-30protein level
2 50 49
2012-10-07protein level
2 50 25
2012-08-24protein level
2 33 25
2012-07-28protein level
2 33 25
2012-06-08protein level
2 39 25
2012-05-07protein level
2 38 25
2012-04-10protein level
2 38 25
2012-01-13protein level
2 33 25
2011-12-20protein level
2 33 25
2011-11-11protein level
2 33 25
2011-08-23protein level
2 33 25
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02671-1
8 26 0 94914.1488
NX_P02671-2
1 26 0 69713.6066
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348571,EBI-701692 APOA1  
  .positive regulation of substrate adhesion-dependent cell spreading
.cholesterol import
.triglyceride homeostasis
  + 61 more...
.high-density lipoprotein particle receptor binding
.phosphatidylcholine-sterol O-acyltransferase activator activity
.lipase inhibitor activity
  + 12 more...
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 17 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder200
blood417
brain1
connective tissue6
embryonic tissue4
heart223
kidney18
liver4262
lung29
lymph22
mammary gland132
muscle37
pancreas9
placenta7
spleen337
stomach10
testis25
uterus12
Health State
TissuesTPM*
normal288
chondrosarcoma12
gastrointestinal tumor8
germ cell tumor7
kidney tumor14
leukemia539
liver tumor551
lung tumor9
lymphoma13
uterine tumor11
Developmental Stage
TissuesTPM*
adult211
embryoid body14
fetus581
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
gallbladder14.3
liver4181.2
lung3.2
pancreas3.4
stomach28.1
testis2.5
Tissues
TissuesExpression level
bone marrowLow
colonMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#105200, phenotype) Amyloidosis, familial visceralOMIM
2(+134820, gene/phenotype) Fibrinogen, a alpha polypeptide; FGAOMIM
3(#202400, phenotype) Afibrinogenemia, congenitalOMIM


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