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> Protein (NX_P02686)
Protein (NX_P02686)
Protein
Gene SymbolMBP to neXtProt (NX_P02686)
DescriptionMyelin basic protein
Chromosome18
Location18q23 (74690783 ~ 74845639) to Ensembl
Sequene Features : Isoforms 6, Variants 54, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to fatty acid
.membrane organization
.negative regulation of axonogenesis
  + 11 more...
.structural constituent of myelin sheath .compact myelin
.neuronal cell body
.internode region of axon
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 54 26
2014-09-19protein level
6 49 26
2014-05-27protein level
6 49 26
2014-02-25protein level
6 49 26
2013-12-09protein level
6 36 26
2013-11-01protein level
6 34 26
2013-09-12protein level
6 34 24
2013-08-17protein level
6 34 24
2013-07-15protein level
6 23 24
2013-06-11protein level
6 23 24
2013-02-12protein level
6 12 109
2012-12-20protein level
6 13 109
2012-10-30protein level
6 17 109
2012-10-07protein level
6 17 24
2012-08-24protein level
6 13 24
2012-07-28protein level
6 13 24
2012-06-08protein level
6 14 24
2012-05-07protein level
6 14 24
2012-04-10protein level
6 14 24
2012-01-13protein level
7 4 24
2011-12-20protein level
7 4 24
2011-11-11protein level
7 4 24
2011-08-23protein level
7 4 24
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02686-1
0 11 0 33097.1931
NX_P02686-2
0 6 0 21509.2843
NX_P02686-3
0 10 0 21479.9047
NX_P02686-4
0 10 0 20233.2513
NX_P02686-5
0 7 0 18579.4077
NX_P02686-6
0 7 0 17332.7543
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-947410,EBI-751587 CTDSP1  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of neuron differentiation
.protein dephosphorylation
  + 2 more...
.metal ion binding
.CTD phosphatase activity
.extracellular exosome
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites125
blood139
bone27
bone marrow61
brain1374
cervix20
connective tissue46
ear248
embryonic tissue18
eye76
heart67
intestine60
kidney8644
larynx85
liver19
lung98
lymph22
lymph node401
mammary gland39
mouth75
muscle112
nerve2124
pancreas112
parathyroid1165
pharynx49
pituitary gland121
placenta24
prostate68
skin669
spleen74
testis16
thymus62
thyroid85
trachea19
uterus56
Health State
TissuesTPM*
cervical tumor28
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor42
germ cell tumor26
glioma83
head and neck tumor59
kidney tumor26309
leukemia95
liver tumor20
lung tumor29
lymphoma41
non-neoplasia15896
pancreatic tumor76
primitive neuroectodermal tumor of the CNS15
prostate cancer48
skin tumor781
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult1109
embryoid body14
blastocyst48
neonate96
fetus96
infant1063
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.8
adrenal gland8.3
appendix22.2
bone marrow17.6
cerebral cortex1153.5
colon17.7
duodenum17.5
esophagus21.8
gallbladder22.4
heart muscle23.2
kidney20.5
liver11.3
lung20.8
lymph node27.4
ovary8.8
pancreas10.7
placenta5.1
prostate14.8
salivary gland12.6
skin25.5
small intestine19.8
spleen25.7
stomach16.7
testis6.7
thyroid gland25.5
urinary bladder23.1
Tissues
TissuesExpression level
cerebellumMedium
cerebral cortexMedium
hippocampusHigh
lateral ventricleHigh
soft tissue 1Low
soft tissue 2Low
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*159430, gene) Myelin basic protein; MBPOMIM


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