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> Protein (NX_P02766)
Protein (NX_P02766)
Protein
Gene SymbolTTR to neXtProt (NX_P02766)
DescriptionTransthyretin
Chromosome18
Location18q12.1 (29171689 ~ 29178974) to Ensembl
Sequene Features : Isoforms 1, Variants 113, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.thyroid hormone transport
.retinol metabolic process
.extracellular matrix organization
  + 3 more...
.thyroid hormone binding
.identical protein binding
.extracellular exosome
.protein complex
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 113 2
2014-09-19protein level
1 109 2
2014-05-27protein level
1 109 2
2014-02-25protein level
1 109 2
2013-12-09protein level
1 106 2
2013-11-01protein level
1 106 2
2013-09-12protein level
1 106 2
2013-08-17protein level
1 106 2
2013-07-15protein level
1 103 2
2013-06-11protein level
1 103 2
2013-02-12protein level
1 94 2
2012-12-20protein level
1 91 2
2012-10-30protein level
1 91 2
2012-10-07protein level
1 91 2
2012-08-24protein level
1 91 2
2012-07-28protein level
1 91 2
2012-06-08protein level
1 95 2
2012-05-07protein level
1 92 2
2012-04-10protein level
1 92 2
2012-01-13protein level
1 109 2
2011-12-20protein level
1 109 2
2011-11-11protein level
1 109 2
2011-08-23protein level
1 109 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02766-1
6 0 0 15877.0025
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711909,EBI-8084264 MT3  
  .negative regulation of reactive oxygen species metabolic process
.positive regulation of oxygen metabolic process
.negative regulation of cysteine-type endopeptidase activity
  + 45 more...
.cadmium ion binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.protein kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.inclusion body
.synaptic vesicle
  + 2 more...
2 EBI-711909,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
3 EBI-711909,EBI-1646426 AGER  
  .positive regulation of NF-kappaB transcription factor activity
.induction of positive chemotaxis
.innate immune response
  + 4 more...
.S100 protein binding
.identical protein binding
.transmembrane signaling receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone marrow20
brain126
ear186
embryonic tissue9
eye344
heart122
kidney18
liver784
lung17
muscle28
ovary9
pancreas6629
parathyroid874
skin14
spleen187
testis4
umbilical cord72
Health State
TissuesTPM*
germ cell tumor11
leukemia10
liver tumor114
ovarian tumor13
pancreatic tumor304
skin tumor23
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult138
blastocyst16
neonate32
fetus211
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.4
cerebral cortex1.5
colon2.6
duodenum6
gallbladder21.8
kidney7.8
liver1891.4
pancreas322.6
skin3.1
small intestine3
spleen1.3
stomach25.8
urinary bladder1
Tissues
TissuesExpression level
kidneyHigh
liverMedium
pancreasMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#105210, phenotype) Amyloidosis, hereditary, transthyretin-relatedOMIM
2(#115430, phenotype) Carpal tunnel syndrome; CTS1OMIM
3(#145680, phenotype) Dystransthyretinemic euthyroidal hyperthyroxinemiaOMIM
4(*176300, gene) Transthyretin; TTROMIM


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