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> Protein (NX_P02786)
Protein (NX_P02786)
Protein
Gene SymbolTFRC to neXtProt (NX_P02786)
DescriptionTransferrin receptor protein 1
Chromosome3
Location3q29 (195754054 ~ 195809060) to Ensembl
Sequene Features : Isoforms 1, Variants 67, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.iron ion import
.transmembrane transport
.positive regulation of bone resorption
  + 5 more...
.poly(A) RNA binding
.identical protein binding
.transferrin receptor activity
.double-stranded RNA binding
.blood microparticle
.extracellular exosome
.recycling endosome
  + 14 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 67 17
2014-09-19protein level
1 55 17
2014-05-27protein level
1 55 17
2014-02-25protein level
1 55 17
2013-12-09protein level
1 42 17
2013-11-01protein level
1 40 17
2013-09-12protein level
1 40 17
2013-08-17protein level
1 40 17
2013-07-15protein level
1 33 13
2013-06-11protein level
1 33 13
2013-02-12protein level
1 14 13
2012-12-20protein level
1 13 13
2012-10-30protein level
1 16 13
2012-10-07protein level
1 16 13
2012-08-24protein level
1 10 13
2012-07-28protein level
1 10 13
2012-06-08protein level
1 38 13
2012-05-07protein level
1 38 13
2012-04-10protein level
1 38 13
2012-01-13protein level
1 42 13
2011-12-20protein level
1 42 13
2011-11-11protein level
1 42 12
2011-08-23protein level
1 42 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02786-1
37 0 1 84817.705
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355727,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-355727,EBI-714423 ALB  
  .response to platinum ion
.transmembrane transport
.maintenance of mitochondrion location
  + 19 more...
.chaperone binding
.pyridoxal phosphate binding
.antioxidant activity
  + 6 more...
.blood microparticle
.extracellular exosome
.protein complex
  + 5 more...
3 EBI-355727,EBI-1028850 HFE  
  .negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.iron ion import into cell
.multicellular organismal iron ion homeostasis
  + 12 more...
.peptide antigen binding
.receptor binding
.antigen binding
.recycling endosome
.perinuclear region of cytoplasm
.basal part of cell
  + 7 more...
4 EBI-355727,EBI-1049513 SH3BP4  
  .cellular response to amino acid stimulus
.protein localization to lysosome
.regulation of catalytic activity
  + 6 more...
.identical protein binding
.Ras GTPase binding
.GDP-dissociation inhibitor activity
.extracellular exosome
.clathrin-coated vesicle
.coated pit
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland516
ascites351
bladder535
blood179
bone83
bone marrow205
brain103
cervix82
connective tissue120
ear62
embryonic tissue140
esophagus843
eye158
heart212
intestine241
kidney147
larynx85
liver321
lung101
lymph45
lymph node245
mammary gland290
mouth907
muscle103
nerve128
ovary88
pancreas46
parathyroid194
pharynx24
pituitary gland60
placenta558
prostate121
skin128
spleen18
stomach229
testis153
thymus125
thyroid128
trachea135
umbilical cord145
uterus137
vascular251
Health State
TissuesTPM*
normal176
adrenal tumor948
bladder carcinoma284
breast (mammary gland) tumor397
cervical tumor86
chondrosarcoma144
colorectal tumor124
esophageal tumor985
gastrointestinal tumor320
germ cell tumor243
glioma102
head and neck tumor485
kidney tumor130
leukemia137
liver tumor343
lung tumor48
lymphoma69
non-neoplasia103
ovarian tumor91
pancreatic tumor47
primitive neuroectodermal tumor of the CNS94
prostate cancer182
retinoblastoma323
skin tumor103
soft tissue/muscle tissue tumor79
uterine tumor199
Developmental Stage
TissuesTPM*
adult210
embryoid body171
blastocyst227
neonate225
fetus161
infant170
juvenile377
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.2
adrenal gland35.1
appendix80
bone marrow224
cerebral cortex20.4
colon82.9
duodenum42.9
esophagus28.9
gallbladder32.9
heart muscle16.4
kidney23.2
liver20.2
lung60.5
lymph node28
ovary27.1
pancreas8.8
placenta129.3
prostate13.1
salivary gland9.1
skin20.8
small intestine37.1
spleen17.7
stomach28.4
testis20.9
thyroid gland23.2
urinary bladder39.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*190010, gene) Transferrin receptor; TFRCOMIM
2non-Hodgkin lymphomaCGP


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