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> Protein (NX_P02792)
Protein (NX_P02792)
Protein
Gene SymbolFTL to neXtProt (NX_P02792)
DescriptionFerritin light chain
Chromosome19
Location19q13.33 (49468558 ~ 49470135) to Ensembl
Sequene Features : Isoforms 1, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.transmembrane transport
.iron ion homeostasis
  + 4 more...
.identical protein binding
.ferric iron binding
.iron ion binding
.extracellular exosome
.membrane
.intracellular ferritin complex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 25 2
2014-09-19protein level
1 23 2
2014-05-27protein level
1 22 2
2014-02-25protein level
1 21 2
2013-12-09protein level
1 18 2
2013-11-01protein level
1 17 2
2013-09-12protein level
1 17 2
2013-08-17protein level
1 17 2
2013-07-15protein level
1 13 1
2013-06-11protein level
1 13 1
2013-02-12protein level
1 8 2
2012-12-20protein level
1 8 2
2012-10-30protein level
1 8 2
2012-10-07protein level
1 8 2
2012-08-24protein level
1 8 2
2012-07-28protein level
1 8 2
2012-06-08protein level
1 14 2
2012-05-07protein level
1 14 2
2012-04-10protein level
1 14 2
2012-01-13protein level
1 40 2
2011-12-20protein level
1 40 2
2011-11-11protein level
1 40 2
2011-08-23protein level
1 40 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02792-1
7 0 0 20007.0455
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713279,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-713279,EBI-713259 FTH1  
  .membrane organization
.transmembrane transport
.negative regulation of fibroblast proliferation
  + 7 more...
.ferric iron binding
.iron ion binding
.ferroxidase activity
.extracellular exosome
.intracellular ferritin complex
.cytosol
.nucleus
3 EBI-713279,EBI-3906629 MYOG  
  .positive regulation of myoblast fusion
.regulation of myoblast fusion
.cellular response to estradiol stimulus
  + 23 more...
.E-box binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 8 more...
.protein-DNA complex
.transcription factor complex
.nucleoplasm
.nucleus
4 EBI-713279,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-713279,EBI-2829310 NAMPT  
  .positive regulation of nitric-oxide synthase biosynthetic process
.positive regulation of smooth muscle cell proliferation
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.nicotinamide phosphoribosyltransferase activity
.drug binding
.cytokine activity
.nicotinate-nucleotide diphosphorylase (carboxylating) activity
.extracellular exosome
.cytosol
.nucleus
.extracellular space
6 EBI-713279,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
7 EBI-713279,EBI-998468 PSENEN  
  .apoptotic signaling pathway
.ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
  + 9 more...
.N/A .gamma-secretase complex
.Golgi cisterna membrane
.integral component of plasma membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1632
adrenal gland2307
ascites1280
bladder3148
blood4179
bone1731
bone marrow5375
brain590
cervix412
connective tissue657
ear62
embryonic tissue488
esophagus49
eye871
heart1295
intestine1086
kidney3406
larynx1789
liver4705
lung2840
lymph293
lymph node222
mammary gland1825
mouth408
muscle733
nerve128
ovary630
pancreas2445
parathyroid1165
pharynx10141
pituitary gland363
placenta696
prostate1772
salivary gland9030
skin1347
spleen2696
stomach637
testis818
thymus75
thyroid193
tonsil528
trachea19
umbilical cord799
uterus969
vascular1742
Health State
TissuesTPM*
normal178
adrenal tumor5294
bladder carcinoma5288
breast (mammary gland) tumor708
cervical tumor434
chondrosarcoma2535
colorectal tumor1208
esophageal tumor57
gastrointestinal tumor827
germ cell tumor1458
glioma1828
head and neck tumor1359
kidney tumor7463
leukemia2667
liver tumor4613
lung tumor2442
lymphoma304
non-neoplasia589
ovarian tumor590
pancreatic tumor4056
primitive neuroectodermal tumor of the CNS291
prostate cancer1579
retinoblastoma516
skin tumor1898
soft tissue/muscle tissue tumor638
uterine tumor588
Developmental Stage
TissuesTPM*
adult182
embryoid body343
blastocyst423
neonate450
fetus425
infant552
juvenile251
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1203.1
adrenal gland810.2
appendix1020.3
bone marrow936.8
cerebral cortex487.4
colon720.3
duodenum965.5
esophagus441
gallbladder1414.5
heart muscle436.5
kidney1523.3
liver1572.6
lung1508.2
lymph node1044.7
ovary755.5
pancreas512.4
placenta1086
prostate397.4
salivary gland385.2
skin260
small intestine1060.3
spleen1373.1
stomach571.7
testis314.2
thyroid gland559.5
urinary bladder1130.9
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
breastLow
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineLow
endometrium 1Medium
endometrium 2Low
epididymisLow
esophagusMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeMedium
nasopharynxLow
oral mucosaLow
pancreasMedium
parathyroid glandMedium
placentaLow
prostateLow
salivary glandLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Low
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*134790, gene) Ferritin light chain; FTLOMIM
2(#600886, phenotype) Hyperferritinemia-cataract syndromeOMIM
3(#606159, phenotype) Neurodegeneration with brain iron accumulation 3; NBIA3OMIM


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