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> Protein (NX_P02794)
Protein (NX_P02794)
Protein
Gene SymbolFTH1 to neXtProt (NX_P02794)
DescriptionFerritin heavy chain
Chromosome11
Location11q12.3 (61727190 ~ 61735132) to Ensembl
Sequene Features : Isoforms 1, Variants 21, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.transmembrane transport
.negative regulation of fibroblast proliferation
  + 7 more...
.ferric iron binding
.iron ion binding
.ferroxidase activity
.extracellular exosome
.intracellular ferritin complex
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 21 7
2014-09-19protein level
1 16 7
2014-05-27protein level
1 16 7
2014-02-25protein level
1 16 7
2013-12-09protein level
1 13 7
2013-11-01protein level
1 13 6
2013-09-12protein level
1 13 4
2013-08-17protein level
1 13 4
2013-07-15protein level
1 7 4
2013-06-11protein level
1 7 4
2013-02-12protein level
1 5 3
2012-12-20protein level
1 4 3
2012-10-30protein level
1 5 3
2012-10-07protein level
1 5 3
2012-08-24protein level
1 1 3
2012-07-28protein level
1 1 3
2012-06-08protein level
1 2 3
2012-05-07protein level
1 2 3
2012-04-10protein level
1 2 3
2012-01-13protein level
1 9 3
2011-12-20protein level
1 9 3
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P02794-1
10 0 0 21212.2324
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713259,EBI-713279 FTL  
  .membrane organization
.transmembrane transport
.iron ion homeostasis
  + 4 more...
.identical protein binding
.ferric iron binding
.iron ion binding
.extracellular exosome
.membrane
.intracellular ferritin complex
.cytosol
2 EBI-713259,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
3 EBI-713259,EBI-751711 MAX  
  .cellular response to peptide hormone stimulus
.retina development in camera-type eye
.neuron apoptotic process
  + 6 more...
.sequence-specific DNA binding
.transcription coactivator activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
.MLL1 complex
.dendrite
.PML body
  + 3 more...
4 EBI-713259,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue2176
adrenal gland1366
ascites1958
bladder1808
blood1096
bone3002
bone marrow3016
brain966
cervix5094
connective tissue1321
ear2360
embryonic tissue1301
esophagus1240
eye2260
heart670
intestine2112
kidney2030
larynx894
liver1480
lung3718
lymph1422
lymph node2228
mammary gland1401
mouth468
muscle1269
nerve1802
ovary2483
pancreas2965
parathyroid1019
pharynx687
pituitary gland847
placenta759
prostate2157
salivary gland12435
skin1855
spleen1086
stomach2727
testis530
thymus200
thyroid1073
tonsil1233
trachea57
umbilical cord1525
uterus1339
vascular2420
Health State
TissuesTPM*
adrenal tumor1738
bladder carcinoma1251
breast (mammary gland) tumor1890
cervical tumor7133
chondrosarcoma4901
colorectal tumor2675
esophageal tumor1391
gastrointestinal tumor3248
germ cell tumor873
glioma1996
head and neck tumor2577
kidney tumor5328
leukemia1005
liver tumor2155
lung tumor6461
lymphoma1232
non-neoplasia1190
ovarian tumor2913
pancreatic tumor4190
primitive neuroectodermal tumor of the CNS370
prostate cancer3322
retinoblastoma753
skin tumor2209
soft tissue/muscle tissue tumor1923
uterine tumor1320
Developmental Stage
TissuesTPM*
embryoid body1686
blastocyst943
neonate740
fetus712
infant1786
juvenile539
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue719.9
adrenal gland464
appendix865.7
bone marrow703.4
cerebral cortex367.1
colon700.9
duodenum450.5
esophagus470.3
gallbladder478
heart muscle363.8
kidney499
liver423
lung576.1
lymph node332.6
ovary401.4
pancreas284.8
placenta387.5
prostate302.6
salivary gland284.9
skin175.2
small intestine547.9
spleen496.7
stomach373.4
testis188.2
thyroid gland485.2
urinary bladder496.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(+134770, gene/phenotype) Ferritin heavy chain 1; FTH1OMIM


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