Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P03372)
Protein (NX_P03372)
Protein
Gene SymbolESR1 to neXtProt (NX_P03372)
DescriptionEstrogen receptor
Chromosome6
Location6q25.1 (151977826 ~ 152450754) to Ensembl
Sequene Features : Isoforms 4, Variants 94, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 94 8
2014-09-19protein level
4 76 8
2014-05-27protein level
4 76 8
2014-02-25protein level
4 74 8
2013-12-09protein level
4 69 8
2013-11-01protein level
4 69 8
2013-09-12protein level
4 68 8
2013-08-17protein level
4 68 8
2013-07-15protein level
4 51 8
2013-06-11protein level
4 51 8
2013-02-12protein level
4 27 24
2012-12-20protein level
4 25 24
2012-10-30protein level
4 28 24
2012-10-07protein level
4 28 10
2012-08-24protein level
4 26 10
2012-07-28protein level
4 24 10
2012-06-08protein level
4 18 9
2012-05-07protein level
4 18 9
2012-04-10protein level
4 18 9
2012-01-13protein level
4 13 9
2011-12-20protein level
4 19 9
2011-11-11protein level
4 19 9
2011-08-23protein level
4 19 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P03372-1
0 24 0 66172.8983
NX_P03372-2
1 19 0 53651.4744
NX_P03372-3
0 19 0 47597.7252
NX_P03372-4
1 11 0 35522.712
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-78473,EBI-357001 HAX1  
  .positive regulation of actin cytoskeleton reorganization
.regulation of protein targeting to mitochondrion
.regulation of mitochondrion degradation
  + 10 more...
.protein N-terminus binding
.interleukin-1 binding
.nuclear membrane
.clathrin-coated vesicle
.lamellipodium
  + 9 more...
2 EBI-78473,EBI-724571 DNM1L  
  .positive regulation of intrinsic apoptotic signaling pathway
.regulation of mitochondrion degradation
.regulation of peroxisome organization
  + 22 more...
.protein homodimerization activity
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.perinuclear region of cytoplasm
.protein complex
.intracellular membrane-bounded organelle
  + 11 more...
3 EBI-78473,EBI-996065 KMT2D  
  .histone H3-K4 methylation
.oogenesis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.transcription regulatory region DNA binding
.histone methyltransferase activity (H3-K4 specific)
.zinc ion binding
.DNA binding
.histone methyltransferase complex
.nucleoplasm
.nucleus
4 EBI-78473,EBI-2831260 KDM6B  
  .cellular response to hydrogen peroxide
.cardiac muscle cell differentiation
.mesodermal cell differentiation
  + 4 more...
.histone demethylase activity (H3-K27 specific)
.dioxygenase activity
.metal ion binding
.sequence-specific DNA binding
.nucleoplasm
.nucleus
5 EBI-78473,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
6 EBI-78473,EBI-1783035 MTA2  
  .positive regulation of transcription from RNA polymerase II promoter
.ATP-dependent chromatin remodeling
.chromatin assembly or disassembly
  + 3 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.zinc ion binding
  + 6 more...
.protein complex
.NuRD complex
.membrane
  + 4 more...
7 EBI-4309277,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
8 EBI-78473,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
9 EBI-78473,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
10 EBI-78473,EBI-351962 DDX5  
  .regulation of skeletal muscle cell differentiation
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of androgen receptor signaling pathway
  + 13 more...
.androgen receptor binding
.poly(A) RNA binding
.pre-mRNA binding
  + 5 more...
.catalytic step 2 spliceosome
.extracellular exosome
.ribonucleoprotein complex
  + 5 more...
11 EBI-78473,EBI-697771 NFKB1  
  .positive regulation of miRNA metabolic process
.positive regulation of hyaluronan biosynthetic process
.positive regulation of canonical Wnt signaling pathway
  + 45 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.I-kappaB/NF-kappaB complex
.cytosol
.mitochondrion
  + 3 more...
12 EBI-78473,EBI-1054703 BTF3  
  .protein transport
.transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.in utero embryonic development
.poly(A) RNA binding .cytoplasm
.nucleus
13 EBI-78473,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
14 EBI-4309277,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
15 EBI-78473,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
16 EBI-78473,EBI-302489 SMARCA4  
  .negative regulation of G1/S transition of mitotic cell cycle
.positive regulation of pri-miRNA transcription from RNA polymerase II promoter
.lens fiber cell development
  + 37 more...
.lysine-acetylated histone binding
.DNA polymerase binding
.androgen receptor binding
  + 11 more...
.nBAF complex
.npBAF complex
.protein complex
  + 10 more...
17 EBI-78473,EBI-716663 PPP5C  
  .protein heterooligomerization
.response to morphine
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 5 more...
.metal ion binding
.identical protein binding
.lipid binding
  + 4 more...
.intracellular membrane-bounded organelle
.neuronal cell body
.neuron projection
  + 5 more...
18 EBI-78473,EBI-78458 PRMT2  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of androgen receptor signaling pathway
.developmental cell growth
  + 9 more...
.androgen receptor binding
.thyroid hormone receptor binding
.peroxisome proliferator activated receptor binding
  + 10 more...
.cytosol
.cytoplasm
.nucleolus
  + 2 more...
19 EBI-78473,EBI-300817 MYL6  
  .ephrin receptor signaling pathway
.muscle filament sliding
.metabolic process
  + 4 more...
.actin-dependent ATPase activity
.structural constituent of muscle
.calcium ion binding
.motor activity
.extracellular exosome
.vesicle
.unconventional myosin complex
  + 4 more...
20 EBI-78473,EBI-767084 RAC3  
  .positive regulation of substrate adhesion-dependent cell spreading
.regulation of small GTPase mediated signal transduction
.neuromuscular process controlling balance
  + 7 more...
.calcium-dependent protein binding
.GTP binding
.GTPase activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 8 more...
21 EBI-78473,EBI-3895726 BLCAP  
  .apoptotic nuclear changes
.cell cycle
.N/A .integral component of membrane
22 EBI-78473,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
23 EBI-78473,EBI-348158 SP3  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 18 more...
.metal ion binding
.double-stranded DNA binding
.chromatin binding
  + 4 more...
.transcriptional repressor complex
.PML body
.plasma membrane
  + 4 more...
24 EBI-78473,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
25 EBI-78473,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
26 EBI-78473,EBI-1108782 FOXO1  
  .regulation of energy homeostasis
.regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
  + 38 more...
.protein phosphatase 2A binding
.sequence-specific DNA binding
.ubiquitin protein ligase binding
  + 4 more...
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
27 EBI-78473,EBI-1373806 AKAP13  
  .regulation of glucocorticoid mediated signaling pathway
.apoptotic signaling pathway
.nuclear export
  + 7 more...
.metal ion binding
.Rho guanyl-nucleotide exchange factor activity
.signal transducer activity
.cAMP-dependent protein kinase activity
.perinuclear region of cytoplasm
.membrane
.cytosol
  + 2 more...
28 EBI-78473,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
29 EBI-78473,EBI-352869 SAFB2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.extracellular exosome
.intracellular membrane-bounded organelle
.cytoplasm
.nucleoplasm
30 EBI-78473,EBI-81236 NCOA2  
  .positive regulation of transcription from RNA polymerase II promoter
.small molecule metabolic process
.cellular lipid metabolic process
  + 11 more...
.nuclear hormone receptor binding
.thyroid hormone receptor coactivator activity
.ligand-dependent nuclear receptor transcription coactivator activity
  + 5 more...
.cytoplasm
.nucleoplasm
.nucleus
31 EBI-78473,EBI-455189 NCOA1  
  .regulation of cellular response to drug
.labyrinthine layer morphogenesis
.male mating behavior
  + 26 more...
.androgen receptor binding
.protein N-terminus binding
.nuclear hormone receptor binding
  + 9 more...
.neuron projection
.cytoplasm
.nucleoplasm
.nuclear chromatin
32 EBI-78473,EBI-9080335 TXNRD1  
  .nucleobase-containing small molecule metabolic process
.cell redox homeostasis
.small molecule metabolic process
  + 8 more...
.flavin adenine dinucleotide binding
.protein disulfide oxidoreductase activity
.electron carrier activity
.thioredoxin-disulfide reductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 2 more...
33 EBI-78473,EBI-8168227 CACUL1  
  .positive regulation of protein kinase activity
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of cell proliferation
.G1/S transition of mitotic cell cycle
.protein kinase binding .anaphase-promoting complex
34 EBI-78473,EBI-1646500 ASXL1  
  .bone development
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of retinoic acid receptor signaling pathway
  + 7 more...
.metal ion binding
.peroxisome proliferator activated receptor binding
.retinoic acid receptor binding
  + 3 more...
.extracellular exosome
.PR-DUB complex
.nuclear chromatin
35 EBI-78473,EBI-2813661 ZNF366  
  .response to estrogen
.negative regulation of intracellular estrogen receptor signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.estrogen receptor binding
.transcription corepressor activity
.DNA binding
.nucleus
36 EBI-78473,EBI-746012 DDX17  
  .regulation of skeletal muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of intracellular estrogen receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.estrogen receptor binding
.RNA-dependent ATPase activity
  + 5 more...
.membrane
.cytoplasm
.nucleolus
  + 2 more...
37 EBI-78473,EBI-740845 PBXIP1  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.multicellular organismal development
.transcription corepressor activity .microtubule
.cytosol
.nucleus
38 EBI-78473,EBI-3895753 SENP5  
  .cell division
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.cysteine-type peptidase activity .intracellular membrane-bounded organelle
.nucleolus
.nucleoplasm
.nucleus
39 EBI-78473,EBI-358348 PHB2  
  .positive regulation of protein stabilization
.positive regulation of ERK1 and ERK2 cascade
.regulation of branching involved in mammary gland duct morphogenesis
  + 10 more...
.protein N-terminus binding
.estrogen receptor binding
.extracellular exosome
.protein complex
.nuclear matrix
  + 5 more...
40 EBI-78473,EBI-2624951 CITED1  
  .response to transforming growth factor beta
.response to parathyroid hormone
.response to interleukin-11
  + 38 more...
.co-SMAD binding
.LBD domain binding
.transcription regulatory region DNA binding
  + 5 more...
.cytosol
.cytoplasm
.nucleus
41 EBI-78473,EBI-5324932 MACROD1  
  .protein de-ADP-ribosylation
.purine nucleoside metabolic process
.cellular response to DNA damage stimulus
.deacetylase activity
.hydrolase activity, acting on glycosyl bonds
.mitochondrion
.nucleus
42 EBI-78473,EBI-2461787 MTA3  
  .negative regulation of transcription, DNA-templated
.chromatin organization
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
43 EBI-78473,EBI-2372223 PAGR1  
  .N/A .N/A .histone methyltransferase complex
.nucleus
44 EBI-78473,EBI-1248228 CUEDC2  
  .N/A .N/A .nuclear membrane
.cytoplasm
.nucleoplasm
45 EBI-78473,EBI-3895741 NDRG2  
  .regulation of platelet-derived growth factor production
.negative regulation of ERK1 and ERK2 cascade
.negative regulation of smooth muscle cell proliferation
  + 6 more...
.N/A .extracellular exosome
.perinuclear region of cytoplasm
.growth cone
  + 6 more...
46 EBI-78473,EBI-749553 ASF1A  
  .muscle cell differentiation
.negative regulation of chromatin silencing
.chromatin modification
  + 6 more...
.histone binding
.chromatin binding
.protein complex
.nucleoplasm
.nucleus
.nuclear chromatin
47 EBI-78473,EBI-5349621 GRIP1  
  .positive regulation of transcription, DNA-templated
.intracellular signal transduction
.androgen receptor signaling pathway
  + 3 more...
.androgen receptor binding
.glucocorticoid receptor binding
.receptor signaling complex scaffold activity
  + 3 more...
.recycling endosome
.postsynaptic membrane
.membrane raft
  + 7 more...
48 EBI-78473,EBI-81196 NCOA3  
  .regulation of RNA biosynthetic process
.mammary gland branching involved in thelarche
.labyrinthine layer morphogenesis
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.thyroid hormone receptor binding
  + 7 more...
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
connective tissue6
embryonic tissue4
eye4
heart22
kidney14
lung8
lymph node11
mammary gland66
muscle75
ovary108
pancreas9
pituitary gland60
prostate31
spleen37
testis9
thymus25
trachea19
uterus249
Health State
TissuesTPM*
normal10
adrenal tumor79
breast (mammary gland) tumor64
chondrosarcoma12
lung tumor9
ovarian tumor91
pancreatic tumor9
uterine tumor377
Developmental Stage
TissuesTPM*
adult21
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.8
adrenal gland2
appendix1.4
colon1.2
esophagus2
gallbladder3.4
heart muscle1.6
kidney2.6
liver36.9
lung2.3
lymph node3
ovary13.6
prostate9.3
spleen1.6
testis3.1
thyroid gland9.9
urinary bladder2.8
Tissues
TissuesExpression level
breastMedium
cervix, uterineHigh
endometrium 1High
endometrium 2High
fallopian tubeHigh
smooth muscleLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(+133430, gene/phenotype) Estrogen receptor 1; ESR1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center