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> Protein (NX_P04049)
Protein (NX_P04049)
Protein
Gene SymbolRAF1 to neXtProt (NX_P04049)
DescriptionRAF proto-oncogene serine/threonine-protein kinase
Chromosome3
Location3p25.2 (12625100 ~ 12705725) to Ensembl
Sequene Features : Isoforms 2, Variants 99, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 99 24
2014-09-19protein level
2 68 24
2014-05-27protein level
2 68 26
2014-02-25protein level
2 66 26
2013-12-09protein level
2 58 26
2013-11-01protein level
2 57 26
2013-09-12protein level
2 57 26
2013-08-17protein level
2 57 26
2013-07-15protein level
2 44 26
2013-06-11protein level
2 44 26
2013-02-12protein level
2 32 56
2012-12-20protein level
2 31 56
2012-10-30protein level
2 36 56
2012-10-07protein level
2 36 28
2012-08-24protein level
2 28 28
2012-07-28protein level
2 28 28
2012-06-08protein level
2 31 28
2012-05-07protein level
2 30 27
2012-04-10protein level
2 30 27
2012-01-13protein level
2 25 27
2011-12-20protein level
2 26 18
2011-11-11protein level
2 26 17
2011-08-23protein level
2 26 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04049-1
0 26 7 73004.7002
NX_P04049-2
1 26 7 75346.8969
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-365996,EBI-536879 OIP5  
  .cell division
.CENP-A containing nucleosome assembly
.cell communication
  + 2 more...
.N/A .Cajal body
.chromocenter
.cytoplasm
  + 4 more...
2 EBI-365996,EBI-350145 HRAS  
  .positive regulation of miRNA metabolic process
.positive regulation of actin cytoskeleton reorganization
.positive regulation of ruffle assembly
  + 53 more...
.protein C-terminus binding
.GTP binding
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 4 more...
3 EBI-365996,EBI-367427 KRAS  
  .response to mineralocorticoid
.response to glucocorticoid
.positive regulation of NF-kappaB transcription factor activity
  + 22 more...
.protein complex binding
.GDP binding
.GMP binding
.GTP binding
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
.membrane
  + 5 more...
4 EBI-365996,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
5 EBI-365996,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
6 EBI-365996,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
7 EBI-365996,EBI-354921 HSPA5  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.regulation of PERK-mediated unfolded protein response
.regulation of IRE1-mediated unfolded protein response
  + 27 more...
.misfolded protein binding
.chaperone binding
.unfolded protein binding
  + 8 more...
.extracellular exosome
.melanosome
.endoplasmic reticulum chaperone complex
  + 13 more...
8 EBI-365996,EBI-353408 PKM  
  .canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
9 EBI-365996,EBI-365980 BRAF  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of synaptic vesicle exocytosis
.positive regulation of substrate adhesion-dependent cell spreading
  + 28 more...
.identical protein binding
.ATP binding
.calcium ion binding
  + 3 more...
.cell body
.neuron projection
.plasma membrane
  + 3 more...
10 EBI-365996,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
11 EBI-365996,EBI-716384 PEBP1  
  .N/A .poly(A) RNA binding
.protein kinase binding
.enzyme binding
  + 3 more...
.extracellular exosome
.cytoplasm
.nucleus
12 EBI-365996,EBI-747671 CDC25A  
  .regulation of cell cycle
.cell division
.cellular response to UV
  + 8 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.cytosol
.nucleoplasm
13 EBI-365996,EBI-536811 CPS1  
  .response to dexamethasone
.cellular response to oleic acid
.cellular response to glucagon stimulus
  + 26 more...
.modified amino acid binding
.glutamate binding
.phospholipid binding
  + 5 more...
.protein complex
.mitochondrial nucleoid
.mitochondrial matrix
  + 2 more...
14 EBI-365996,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
15 EBI-365996,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
16 EBI-365996,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
17 EBI-365996,EBI-356673 CCT3  
  .toxin transport
.'de novo' posttranslational protein folding
.pore complex assembly
  + 3 more...
.unfolded protein binding
.poly(A) RNA binding
.ATP binding
.extracellular exosome
.cell body
.plasma membrane
  + 6 more...
18 EBI-365996,EBI-1541912 RCAN1  
  .regulation of calcineurin-NFAT signaling cascade
.regulation of catalytic activity
.calcium-mediated signaling
  + 4 more...
.identical protein binding
.calcium-dependent protein serine/threonine phosphatase regulator activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleus
19 EBI-365996,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
20 EBI-365996,EBI-491414 RAP1A  
  .positive regulation of vasculogenesis
.negative regulation of synaptic vesicle exocytosis
.cellular response to nerve growth factor stimulus
  + 18 more...
.protein complex binding
.Rap guanyl-nucleotide exchange factor activity
.protein transporter activity
  + 2 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 7 more...
21 EBI-365996,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
22 EBI-365996,EBI-492564 MAP2K1  
  .regulation of early endosome to late endosome transport
.activation of mitophagy in response to mitochondrial depolarization
.cellular senescence
  + 55 more...
.protein N-terminus binding
.protein serine/threonine kinase activator activity
.protein C-terminus binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.perikaryon
  + 15 more...
23 EBI-365996,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
24 EBI-365996,EBI-5278441 NFATC3  
  .cellular response to lithium ion
.cellular response to calcium ion
.muscle cell development
  + 11 more...
.chromatin binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.cytosol
.cytoplasm
.nucleolus
  + 2 more...
25 EBI-365996,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
26 EBI-365996,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
27 EBI-365996,EBI-355175 TIMM50  
  .cellular protein metabolic process
.peptidyl-tyrosine dephosphorylation
.mitochondrial membrane organization
  + 3 more...
.ribonucleoprotein complex binding
.interleukin-2 receptor binding
.protein tyrosine phosphatase activity
  + 3 more...
.nuclear speck
.integral component of membrane
.mitochondrial inner membrane presequence translocase complex
  + 3 more...
28 EBI-365996,EBI-700771 BAD  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
29 EBI-365996,EBI-8563667 PEBP4  
  .N/A .N/A .extracellular exosome
.lysosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites175
blood229
bone167
bone marrow102
brain121
cervix144
connective tissue114
ear248
embryonic tissue178
esophagus99
eye114
heart189
intestine77
kidney85
larynx170
liver82
lung203
lymph22
lymph node155
mammary gland99
mouth287
muscle84
nerve257
ovary68
pancreas98
parathyroid97
pituitary gland60
placenta134
prostate126
skin265
spleen18
stomach94
testis163
thymus476
thyroid85
trachea270
umbilical cord72
uterus73
vascular77
Health State
TissuesTPM*
normal129
adrenal tumor158
breast (mammary gland) tumor96
cervical tumor202
chondrosarcoma229
colorectal tumor44
esophageal tumor115
gastrointestinal tumor160
germ cell tumor186
glioma83
head and neck tumor179
kidney tumor72
leukemia296
liver tumor124
lung tumor204
lymphoma110
non-neoplasia113
ovarian tumor52
pancreatic tumor57
primitive neuroectodermal tumor of the CNS125
prostate cancer202
retinoblastoma86
skin tumor295
soft tissue/muscle tissue tumor63
uterine tumor66
Developmental Stage
TissuesTPM*
adult130
embryoid body100
blastocyst244
neonate257
fetus226
infant212
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.4
adrenal gland33.5
appendix50.7
bone marrow96.5
cerebral cortex32.1
colon42.6
duodenum48.5
esophagus50.9
gallbladder44.2
heart muscle75.4
kidney44.6
liver37.5
lung50.5
lymph node50.4
ovary58.2
pancreas28.6
placenta49
prostate44.3
salivary gland31.4
skin57.1
small intestine53.3
spleen55.9
stomach46.2
testis38.7
thyroid gland54.9
urinary bladder44.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164760, gene) V-raf-1 murine leukemia viral oncogene homolog 1; RAF1OMIM
2(#611553, phenotype) Noonan syndrome 5; NS5OMIM
3(#611554, phenotype) Leopard syndrome 2OMIM
4pilocytic astrocytomaCGP


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